LIQUISOLID COMPACT OF MECLIZINE HYDROCHLORIDE: DEVELOPMENT AND OPTIMIZATION USING FACTORIAL DESIGN

TULARAM BAROT; KARUNA NAGULA; MOKSHA PATEL; L D PATEL

doi:10.22159/ijap.2025v17i2.53361

Authors

TULARAM BAROT Parul Institute of Pharmacy and Research, Faculty of Pharmacy, Parul University, Vadodara, India https://orcid.org/0000-0002-6838-6232
KARUNA NAGULA Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India
MOKSHA PATEL Department of Pharmaceutics, ROFEL, Shri G.M. Bilakhia College of Pharmacy, Vapi, Gujarat, India
L D PATEL Department of Pharmaceutics, ROFEL, Shri G.M. Bilakhia College of Pharmacy, Vapi, Gujarat, India 4Ex Director PG, Faculty of Pharmacy, Parul University, Vadodara, India

DOI:

https://doi.org/10.22159/ijap.2025v17i2.53361

Keywords:

Meclizine hydrochloride, Liquisolid compact, Factorial design, Motion sickness

Abstract

Objective: The study focuses on improving the dissolution rate of meclizine hydrochloride by developing liquisolid compact.

Methods: Meclizine hydrochloride is used to prevent motion sickness but has slow dissolution, requiring it to be taken an hour before travel. Various water-miscible solvents were examined to determine the drug's solubility, with propylene glycol showing the highest solubility. Avicel^® PH 102 was chosen as the carrier, and Aerosil^® 200 as the coating material. The formulation was optimized using Design Expert software and 3² factorial design was used to study the effects of factors: carrier and coating ratio(X₁) and drug concentration in liquid medication (%Cd)(X₂) on responses: %cumulative drug release at 20 minutes (Y₁) and angle of repose(Y₂).

Results: The optimized formulation was selected using the software, with a carrier and coating ratio of 24.89 and drug concentration in liquid at 10.14% w/w. The optimized liquisolid tablet was evaluated for post-compression parameters and dissolution study. The drug was found to be non-crystalline based on Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD) studies, and the stability study showed no significant degradation.

Conclusion: The findings indicate that liquisolid formulation can be a promising alternative to achieve rapid onset of action and dissolution enhancement for poorly water-soluble drugs such as meclizine hydrochloride.

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