EVALUATION OF ANTIARTHRITIC ACTIVITY OF SCHISANDRA GRANDIFLORA AGAINST FORMALDEHYDE-INDUCED ARTHRITIS IN RATS
Keywords:
Schisandra grandiflora, Formaldehyde, IndomethacinAbstract
Objective: Schisandra grandiflora is a plant, reported for its variety of ethnic medicinal uses. The current study was undertaken to evaluate the antiarthritic activity of S. grandiflora against formaldehyde-induced arthritis in rats.
Methods: The plant powder successively extracted with water and subjected for phytochemical screening to identify the different phytochemical constituents. LD50 study is conducted for the aqueous extract up to the dose level of 2000 mg/kg by following the method of OECD guidelines no. 425.
Results: Preliminary phytochemical studies revealed the presence of terpenoids, flavonoids, alkaloids, and glycosides in aqueous extract of S. grandiflora. No mortality was observed with the aqueous up to the maximum dose level of 2000 mg/kg. Further, aqueous extracts at 100 and 200 mg/kg, p.o but not with 100 mg/kg p.o dose significant (p<0.01) reduced paw edema in formaldehyde-induced arthritis in rats.
Conclusion: The present study revealed the antiarthritic activity extract of S. grandiflora. Moreover, the activity is showed the presence of phytochemical constituents such as terpenoids, alkaloids, glycosides, and flavonoids as these phytochemical constituents.
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