OPTIMIZING TRANSDERMAL PATCH FORMULATION FOR ENHANCED DELIVERY OF RIVAROXABAN: A COMPREHENSIVE DESIGN OF EXPERIMENTS APPROACH

RAMA RAO NADENDLA

doi:10.22159/ijpps.2024v16i12.51075

Authors

RAMA RAO NADENDLA Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur-522034, Andhra Pradesh, India

DOI:

https://doi.org/10.22159/ijpps.2024v16i12.51075

Keywords:

Rivaroxaban, Transdermal patches, Factorial design, in vitro drug release, hydroxypropylmethylcellulose

Abstract

Abstract:

Objective: To optimize transdermal patches of rivaroxaban (RXB) using polyvinylpyrolidine (PVP K30), hydroxypropylmethylcellulose (HPMC E50) as hydrophilic polymer, propylene glycol as plasticizer and permeation enhancer.

Methods: The TD patches were crafted through the solvent casting technique using 2-level, 3-factor factorial design. These patches underwent assessment for thickness, folding endurance, in vitro drug release, drug content, moisture uptake, and moisture loss. An 8-stage diffusion cell apparatus facilitated the in vitro drug release testing. Here the independent variables were HPMC E50, PVP K30, Propylene glycol. The change in the concentration of these independent variables results in the optimization of TD patch. The dependent variables are thickness, folding endurance, in vitro diffusion studies.

Results: The patches exhibited the desired properties. Propylene glycol enhanced the permeation of RXB. It shows that 94.58% of drug release was achieved in 24hrs.

Conclusion: Propylene glycol increased the release of RXB because it permeates through the membrane. Whereas, HPMC E50 has the high solubility. Thus, RXB transdermal patches were potentially suitable for transdermal drug delivery system.

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