A STUDY ON ADVERSE DRUG REACTIONS IN HOSPITALIZED PATIENTS WITH DIABETES MELLITUS IN A MULTI -SPECIALITY TEACHING HOSPITAL

Authors

  • Javedh Shareef NITTE UNIVERSITY
  • Jennifer Fernandes
  • Laxminarayana Samaga
  • Shifaz Abdul Khader

Abstract

ABSTRACT
Objectives: Adverse drug reactions (ADRs) are well known to occur with any class of drugs when used in normal doses for the management of
diseases. Anti-diabetic agents are no exception to this. The main aim of the study was to detect and analyze ADRs in hospitalized patients with diabetes
mellitus in a multi-specialty hospital.
Methods: The prospective observational study was conducted in a 1000 bed multi-disciplinary teaching hospital at Dakshin Kannada district in south
India over a period of 2-year between June 2013 and May 2015.
Results: A total of 102 ADRs were reported from 99 patients during the study period with male predominance (60.60%) over females. The average
age of the patients in the study was found to be 59.8±13.15 years. The majority of the ADRs occurred in the age group of 40-80 years. The average
duration of diabetes mellitus in the study was 10.08±7.69 years. The class of drugs most commonly responsible for causing ADRs was found to be
anti-diabetic drugs (67.64%) followed by antimicrobial agents (10.78%). The most commonly occurred ADRs was hypoglycemia (63.72%) followed
by gastritis (6.86%). Causality assessment by using Naranjo scale indicated that majority of the ADRs (59.80%) were probable, 37.25% were possible,
and 2.94% were definite. The severity assessment using the Hartwig and Siegal scale indicated that the majority of the ADRs were mild†followed
by moderate†and severe,†respectively. Preventability assessment using modified Schumock and Thornton revealed that 57.84% were definitely
preventable, 33.33% were probably preventable, and 8.82% were not preventable.
Conclusion: The study shows that the active involvement of a clinical pharmacist helps in monitoring and detecting ARDs and their management
through therapeutic interventions would be beneficial in the better patient outcome.
Keywords: Adverse drug reaction, Diabetes mellitus, Clinical pharmacist.

Downloads

Download data is not yet available.

References

Coren J, Overbeck K, Filipetto F. Evaluating medications and adverse drug reactions in older patients [Internet]. 2011 [cited 7 November 2015]. Available from: http://www.cecity.com/aoa/healthwatch/may_11/print2.pdf

Raut A L, Patel P, Patel C and Pawar A. Preventability, predictability and seriousness of adverse srug reactions amongst medicine inpatients in a teaching hospital: A prospective Observational Study. International Journal of Pharmaceutical and chemical sciences; 1(3) Jul-Sep 2012: 1293-1298.

Padmaja S Y and Palaniswamy S. A study on Assessment, Monitoring and Documentation of adverse Drug Reactions. IJPTP 2012; 3(2): 253-256.

Shamna S, Dilip C, Ajmal M, Linu M P, Shinu C, Jafer C P, Mohammed Y. A prospective study on adverse drug reactions of antibiotics in a tertiary care hospital. Saudi Pharmaceutical Journal 2014; 22: 303-308. http://dx.doi.org/10.1016/j.jsps.2013.06.004

Bhabhor P H, patel T K, Vahora R, Patel P B, Desai N. Adverse drug reactions in a tertiary care teaching hospital in India: analysis of spontaneous reported cases. Int J Basic Clin Pharmacol 2014; 3(6): 1078-1085.doi: 10.5455/2319-2003.1jbcp20141228

Roy K, Divya S, Nadig P, Prakash B. Monitoring and analysis of adverse drug reaqctions ina private tertiary care teaching hospital. Asian J Pharm Clin Res 2015; 8(2): 335-37.

Swamy S, Bhanuprakash, Nadig P, Muralimohan, Shetty M. Profile of suspect adeverse drug reactions in a teaching tertiary care hospital. Hospital J Pharmacol Clin Toxicol ; 1(1): 1005(2013).

Mrugank B P and Hareesha R P. Prospective observational, Non-randomized, parallel sequence study for Assessment of adverse drug reactions due to chemotherapeutic treatment in different types of cancer patients. IJPSR 2013;4(1): 386-391.

Ramanath K V et al. A study on Assessment of Adverse drug reactions in Tuberculosis patients. Am J Pharm Tech Res 2012; 2(2): 585-91.

Verma R, Verma J, Verma N, Sharma P, Rai N. A study of adverse drug reactions in pediatric age group with assessment of causality, severity and preventability in a tertiary care hospital. Journal of Dental and Medical sciences 2014;13(5): 42-48.

Rao PG, Archana B, Jose J. implementation and results of an adverse drug reactions reporting programme at an Indian teaching hospital. Indian Journal Pharmacology 2006;38:293-296.

Dilip C, Lisa Mari and Saraswathi R et al. Adverse drug reactions monitoring in tertiary level hospital, perithalamanna, Kerala. Indian Journal of hospital pharmacy 2011;48:107-111.

Rajesh R, Ramesh M and Parthasarathi G. A study on adverse drug reactions related hospital admission and their management. Indian journal of hospital pharmacy 2008;45: 143-148.

Munir Pirmohamed, Sally James, shaun Meakin et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. BMJ 2004;329:15-19.

Zaman Huri and Fun Wee. Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study. BMC Endocrine Disorders 2013; 13(2). http://www.biomedcentral.com/1472-6823/13/2

Vijayakumar T M and Dhanaraju M D. Description of adverse drug reactions in a Multi-speciality teaching Hospital. Int J Integr med 2013; 1(26): 1-6.

Dindayal P, Mithun S R, Nilesh P N, wnny S. Implementation and evaluation of adverse drug reaction monitoring system in a tertiary care teaching hospital in Mumbai, India. Interdiscip Toxicol 2013; 6(1): 41-46.doi: 10.2478/intox-2013-0008

Van Roozendaal BW, Krass I. Development of an evidence-based checklist for the detection of drug related problems in type 2 diabetes. Pharm World Sci 2009; 31(5): 580-595.

Chua SS, Kok LC, Yusof FAM, Tang GH, Lee SWH, Efendie B et al. Pharmaceutical care issues identified by pharmacist in patients with diabetes, hypertension or hyperlipidemia in primary care settings. BMC Health Services Research 2012; 12: 388. http://www.biomedcentral.com/1472-6963/12/388.

Hallas J, Gram L F, Grodum E et al. Drug related admissions to medical wards: a population based survey. Br. J Clin Pharmac 1992;33: 61-8.

Chan TYK, Critchley JAJH. Drugrelated problems as a cause of hospital admissions in Hong Kong. PHARMACOEPIDEMIOLOGY-DRUG-SAF 1995; 4(3):165-70.

Chan T Y, Chan JC, Tomlinson B, Critchley JA. Adverse reactions to drugs as a cause of admissions to a general teaching hospital in Hong Kong. Drug Saf 1992; 7(3):235-40.

Pizzimenti V, Ientile V, Fava G, Giudice I, Bonfiglio C, Alecci U et al. Adverse reactions with antidiabetic drugs: results from a prospective cohort study in Sicily [Internet]. 2015 [cited 10 November 2015]. Available from: http://congresso.sifweb.org/archivio/cong36/abs/379.pdf

Published

01-03-2016

How to Cite

Shareef, J., J. Fernandes, L. Samaga, and S. A. Khader. “A STUDY ON ADVERSE DRUG REACTIONS IN HOSPITALIZED PATIENTS WITH DIABETES MELLITUS IN A MULTI -SPECIALITY TEACHING HOSPITAL”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 114-7, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/10026.

Issue

Section

Original Article(s)