CIRCULATORY AUTOANTIBODIES AGAINST HYALURONIC ACID BINDING PROTEINS: A NOVEL SERUM BIOMARKER

Authors

  • Venkatrao Nunna
  • Banerjee SD
  • Karuna Kumar M University of mysore

Keywords:

autoantibodies, cancer, HABPs, HC, serum

Abstract

Background: Circulating autoantibodies have been extensively investigated as possible markers for early diagnosis of cancer. The present study was carried out to investigate whether anti-HABPs autoantibodies could be classified as a serum biomarker for malignant tumors.

Methods: An enzyme-linked immunosorbent assay, western blot was used to detect anti-HABPs autoantibodies in sera from 99 patients with various types of cancers and 50 healthy subjects matched by age and gender.

Result: Our results clearly indicated that patients with cancer have significant higher circulating levels of anti-HABPs antibodies as compared to control subjects (𑃠< 0.001). Receiver operating characteristic plot test has exhibited 91.9% sensitivity and 76.3% specificity.

Conclusion: anti-HABPs autoantibodies are promising biomarker for malignant tumors and could play a role in the development of multimarker assay for the early detection of cancer

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Published

01-04-2014

How to Cite

Nunna, V., B. SD, and K. K. M. “CIRCULATORY AUTOANTIBODIES AGAINST HYALURONIC ACID BINDING PROTEINS: A NOVEL SERUM BIOMARKER”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 2, Apr. 2014, pp. 199-03, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/1005.

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