A STUDY ON SERUM URIC ACID LEVEL AND RISK FACTORS IN NON-EMBOLIC STROKE PATIENT IN TERTIARY CARE HOSPITAL
Abstract
Objectives: To find out the serum level of uric acid among non-embolic stroke patients. To find out the level of uric acid in various risk factors of
stroke.
Methods: The study was conducted among 100 patients admitted with non-embolic stroke in tertiary care hospital to find out serum level of uric
acid and various existing risk factors for non-embolic stroke. The serum level of uric acid was measured within 24 hrs, the demographic profile like
age and sex risk factors such as hypertension, diabetes mellitus, dyslipedemia, smoking, and alcohol were elicited. The appropriate statistical analysis
was performed.
Results: This study was done among 100 patients with non-embolic stroke patients. Out of 100, 63% of the stroke patients were in the age of between
51 and 70 years. Mean age was 59 years. The gender wise distribution was 49% male and 51% female. The mean serum uric acid (SUA) level among
all the stroke patients was 5.3 mg/dl. The SUA was increased above the normal level in 33% of the stroke patients. According to univariate analysis, the
presence of hypertension was 66% followed by diabetes mellitus 53%. Cardiovascular disease was 33%, dyslipidemia was 40%, smoking was 33%,
and alcoholism was 20%. The SUA level was raised above normal level among the patients who had hypertension, diabetes mellitus as a risk factor
and it is statistically significant.
Conclusion: There is a certain proportion of stroke patient's SUA level raised above normal level and hypertension was a major risk factor for stroke.
Secondary prevention of hypertension is mandatory to avoid stroke.
Keywords: Serum uric acid, Stroke, Risk factors.
Downloads
References
Ropper A, Samuels M, Klein J. Adam and Victor’s Principles of Neurology.
th ed., Ch. 34. New York: McGraw Hill Professional; 2014. p. 660-9.
Squadrito GL, Cueto R, Splenser AE, Valavanidis A, Zhang H,
Uppu RM, et al. Reaction of uric acid with peroxynitrite and
implications for the mechanism of neuroprotection by uric acid. Arch
Biochem Biophys 2000;376(2):333-7.
Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric
acid and serum antioxidant capacity: A reaction to atherosclerosis?
Atherosclerosis 2000;148(1):131-9.
Tayag EC, Nair SN, Wahhab S, Katsetos CD, Lighthall JW, Lehmann JC.
Cerebral uric acid increases following experimental traumatic brain
injury in rat. Brain Res 1996;733(2):287-91.
Kanemitsu H, Tamura A, Kirino T, Karasawa S, Sano K, Iwamoto T,
et al. Xanthine and uric acid levels in rat brain following focal ischemia.
J Neurochem 1988;51(6):1882-5.
Daskalopoulou SS, Athyros VG, Elisaf M, Mikhailidis DP. Uric acid
levels and vascular disease. Curr Med Res Opin 2004;20(3):951-4.
Lehto S, Niskanen L, Rönnemaa T, Laakso M. Serum uric acid is a
strong predictor of stroke in patients with non-insulin-dependent
diabetes mellitus. Stroke 1998;29(18):635-9.
Fang J, Alderman MH. Serum uric acid and cardiovascular mortality
the NHANES I epidemiologic follow-up study, 1971-1992. National
health and nutrition examination survey. JAMA 2000;283:2404-10.
Patil TB, Pasari AS, Sargar KM, Shegokar VE, Bansod YV, Patil MB.
Serum uric acid levels in acute ischemic stroke: A study of 100 patients.
J Neurol Res 2011;1(5):193-200.
Mehrpour M, Khuzan M, Najimi N, Motamed MR, Fereshtehnejad SM.
Serum uric acid level in acute stroke patients. Med J Islam Repub Iran
;26(2):66-72.
Iranmanesh F, Sheykholeslami NZ, Gadari F, Ahmady J. Acute
ischemic non-embolic stroke and serum level of uric acid. Iran J Neurol
;11(1):1-5.
Koppula R, Kaul S, Rao AV, Jyothy A, Munshi A. Association of
serum uric acid level with ischemic stroke, stroke subtypes and clinical
outcome. Neurol Asia 2013;18(4):349-53.
Milionis HJ, Kalantzi KJ, Goudevenos JA, Seferiadis K, Mikhailidis
DP, Elisaf MS. Serum uric acid levels and risk for acute ischaemic nonembolic
stroke in elderly subjects. J
Intern
Med 2005;258(5):435-41.
Seghieri G, Moruzzo D, Fascetti S, Bambini C, Anichini R, De Bellis A,
et al. Increase in serum uric acid is selectively associated with stroke in
type 2 diabetes. Diabetes Care 2002;25(6):1095.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.