TASTE MASKED ORODISPERSIBLE TABLETS: A HIGHLY PATIENT COMPLAINT DOSAGE FORM

Authors

  • Shivangi Singh School of pharmaceutucal Sciences, IFTM University Moradabad
  • Navneet Verma

Abstract

Objective: Tablet is still most popular conventional dosage forms existing today, but the drawback of solid dosage forms is the difficulty in swallowing
(dysphagia) or chewing in some patients particularly pediatric and geriatric patients. For this reason, orodispersible tablets (ODT) that can rapidly
dissolve or disintegrate in the oral cavity have attracted a great deal of attention. The main objective of this review is to explore various methodologies
for masking the taste of obnoxious drugs, applications, evaluation and also the recent trends in taste masking technologies when prepare a ODT.
Methods: Pediatric and geriatric populations are the most sensitive to the bad taste of medicaments, thus in these cases patient compliance reduces.
This reason is an initiative for the development of various taste masking technologies by which the characteristics of ODT is improved and good
patient compliance is achieved.
Results: ODTs have better patient acceptance and compliance and may offer improved biopharmaceutical properties, improved efficacy, and better
safety compared with conventional oral dosage forms. Prescription ODT products initially were developed to overcome the difficulty in swallowing
conventional tablets among pediatric, geriatric, and psychiatric patients with dysphagia.
Conclusion: In this review, various techniques discussed which can help to overcome bitter taste of active pharmaceutical ingredients as well as
largely improve the product preference among patients. It will also enhance the quality of the treatment provided to patients, especially children and
older patients. Furthermore, various techniques could be combined to develop palatable and cost-effective ODTs.
Keywords: Orodispersible tablet, Taste masking, Patient compliance.

Downloads

Download data is not yet available.

Author Biography

Shivangi Singh, School of pharmaceutucal Sciences, IFTM University Moradabad

Assistant Professor

School of Pharmaceurical Sciences

References

Shah PP, Mashru RC. Development and evaluation of artemether taste

masked rapid disintegrating tablets with improved dissolution using

solid dispersion technique. AAPS Pharm Sci Tech 2008;9(2):494-500.

Douroumis DD, Gryczke A, Schminke S. Development and evaluation

of cetirizine HCl taste-masked oral disintegrating tablets. AAPS

Pharm Sci Tech 2011;12(1):141-51.

Noorjahan A, Amrita B, Kavita S. In vivo evaluation of taste masking

for developed chewable and orodispersible tablets in humans and rats.

Pharm Dev Technol 2014;19(3):290-5.

Ahmed SZ, Bader MA, Mahmoud M, Tamer MS. Taste-masked

orodispersible tablets of cyclosporine self nanoemulsion lyophilized

with dry silica. Pharm Dev Technol 2014;9(8):1-8.

Drewnowski A, Gomez-Carneros C. Bitter taste, phytonutrients, and

the consumer: A review. Am J Clin Nutr 2000;72(6):1424-35.

Rodgers S, Busch J, Peters H, Christ-Hazelhof E. Building a tree of

knowledge: Analysis of bitter molecules. Chem Senses 2005;30(2):547-57.

Shishu, Kamalpreet, Kapoor VR. Development of taste masked oral

formulation of ornidazole. Indian J Pharm Sci 2010;72(2):211-5.

Alshehri SM, Park JB, Alsulays BB, Tiwari RV, Almutairy B,

Alshetaili AS, et al. Mefenamic acid taste-masked oral disintegrating

tablets with enhanced solubility via molecular interaction produced

by hot melt extrusion technology. J Drug Deliv Sci Technol

;27(3):18-27.

Vummaneni V, Nagpal D. Taste masking technologies: An overview

and recent updates. Int J Res Pharm Biomed Sci 2012;3(2):510-9.

Sonawane V, Saiffee M, Shinde N, Hawaldar A, Pawar A. An update

of taste masking methods and evaluation techniques. Der Pharm Let

;2(1):1-15.

Vummaneni V, Nagpal D. Recent taste masking technologies: An

overview and updates. Int J Res Pharm Biomed Sci 2012;3(2):510-24.

Sharma D, Kumar D, Singh M, Singh G, Rathore M. Taste masking

technologies: A novel approach for the improvement of the organoleptic

property of pharmaceutical active substance. Int Res J Pharm

;3(2):108-16.

Sharma S, Lewis S. Taste masking technologies: A review. Int J Pharm

Pharm Sci 2010;2(1):6-13.

Rafik K. Computationally designed prodrugs for masking the bitter

taste of drugs. Drug Des Open Access 2012;4(1):120-9.

Thoke S, Gayke A, Dengale R, Patil P, Sharma Y. Review on: Taste

masking approaches and evaluation of taste masking. Int J Pharm Sci

;4(2):1895-907.

Tripathi A, Parmar D, Patel U, Patel G, Daslaniya D, Bhimani B. Taste

masking: A novel approach for bitter and obnoxious drugs. J Pharm Sci

Biopharm Res 2011;1(1):136-42.

Asian J Pharm Clin Res, Vol 9, Issue 3, 2016, 385-391

Singh and Verma

Jha Kumar JS, Sharma RU, Surendra V. Taste masking in

pharmaceuticals: An update. J Pharm Res 2008;1(2):126-30.

Mashkevich OB. Drug Delivery Research Advances. New York: Nova

Science Publishers; 1998. p. 117-52.

Sharma S, Lewis S. Taste masking technologies: A review. Int J Pharm

Pharm Sci 2010;2(2):6-13.

Vijay D, Shyam V. Taste masking methods and technologies in oral

pharmaceuticals: Current perspectives. J Pharm Res 2009;2(6):1049-54.

Wadhwa J, Puri S. Taste masking: A novel approach for bitter and

obnoxious drugs. Int J Biopharm Toxicol Res 2011;1(1):47-60.

Yoshida T, Lai TC, Kwon GS, Sako K. pH and ion sensitive polymers

for drug delivery. Int J Biopharm Toxicol Res 2013;1(1):46-58.

Diego AT. Protein free microcapsules obtained from plant spores as

a model for drug delivery: Ibuprofen encapsulation release and taste

masking. J Mater Chem 2013;1(3):707.

Kaushik D, Dureja H. Recent patents and patented technology

platforms for pharmaceutical taste masking. Recent Pat Drug Deliv

Formul 2014;8:37-45.

Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral

pharmaceuticals: Recent developments and approaches. Drug Dev Ind

Pharm 2004;30(5):429-48.

Virely P, Yarwood R. Zydis a novel, fastdissolving dosage form. Manuf

Chem 1990;61:36-7.

Seager H. Drug-delivery products and the Zydis fast-dissolving dosage

form. J Pharm Pharmacol 1998;50(1):375-82.

Mishra DN, Bindal M, Singh SK, Vijaya Kumar SG. Spray dried

excipient base: A novel technique for the formulation of orally

disintegrating tablets. Chem Pharm Bull (Tokyo) 2006;54(1):99-102.

Masareddy R, Kokate A, Shah V. Development of orodispersible

tizanidine HCl tablets using spray dried coprocessed exipient bases.

Indian J Pharm Sci 2011;73(6):392-6.

Koizumi K, Watanabe Y, Morita K, Utoguchi N, Matsumoto M. New

method of preparing highporosity rapidly saliva soluble compressed

tablets using mannitol with camphor, a subliming material. Int J Pharm

;152(1):127-31.

Kumar R, Patil MB, Patil SR, Paschpura MS. Development &

characterization of melt-in tablets of haloperidol by sublimation

technique. Int J Pharm Pharm Sci 2009;1(1):65-73.

Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets:

An overview of formulation technology. Sci Pharm 2009;77(1):309-26.

Bhowmik D, Chiranjib B, Pankaj K, Chandira RM. Orodispersible

tablet: An overview. J Chem Pharm Res 2009;1(1):163-77.

Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of rapidly

disintegrating tablets manufactured by phase transition of sugar

alcohols. J Control Release 2005;105(1-2):16-22.

Kearney P, Wong SK. Method for making freeze dried drug dosage

forms. U. S. Patent 5, 631, 023; 1997.

Wehling F, Schuehle, S, Madamala N. Effervescent dosage form with

microparticles. U. S. Patent 5, 178, 878; 1993.

Katzner L, Jones B, Khattar J, Kosewick J. Blister package and

packaged tablet. U. S. Patent 6, 155, 423; 2000.

Pebley WS, Jager NE, Thompson SJ. Rapidly disintegrating tablets.

U. S. Patent 5, 298, 261; 1994.

Robinson J, Ginity J. Effervescent granules and method for their

preparation. U. S. Patent 6, 488, 961; 2002.

Mizumoto T, Masuda Y, Fukui M. Intrabuccally dissolving compressed

moldings and production process there. U. S. Patent 5, 576, 014; 1996.

Khankari R, Hontz J, Chastain S, Katzner L. Rapidly dissolving robust

dosage form. U. S. Patent 6, 981, 024; 2000.

Jeong SH, Fu Y, Park K. Frosta: A new technology for making fast-

melting tablets. Expert Opin Drug Deliv 2005;2(6):1107-16.

Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating

tablets: Developments, technologies, taste-masking and clinical studies.

Crit Rev Ther Drug Carrier Syst 2004;21(6):433-76.

Kaushik D, Dureja H, Saini TR. Orally disintegrating tablets: An

overview of melt-in mouth tablet technologies and techniques. Tablets

Capsules 2004;2(1):30-6.

Dobetti L. Fast Disintegrating tablets. P. C. T Patent 99, 445, 8; 1999.

Mohammad Y, Mohammad I. Drug food interactions and role of

pharmacist. Asian J Pharm Clin Res 2009;2(4):1181-6.

Rachid O, Simons FE, Rawas-Qalaji M, Simons KJ. An electronic

tongue: Evaluation of the masking efficacy of sweetening and/or

flavoring agents on the bitter taste of epinephrine. AAPS Pharm Sci Tech

;11(2):550-7.

Miyanaga Y, Inoue N, Ohnishi A, Fujisawa E, Yamaguchi M, Uchida T.

Quantitative prediction of the bitterness suppression of elemental diets

by various flavors using a taste sensor. Pharm Res 2003;20(2):1932-8.

Katsuragi Y, Kashiwayanagi M, Kurihara K. Specific inhibitor for bitter

taste: Inhibition of frog taste nerve responses and human taste sensation

to bitter stimuli. Brain Res Brain Res Protoc 1997;1(1):292-8.

Malke S, Shidhaye S, Kadam V. Novel melt granulation using sugars

for metoclopramide hydrochlorideorally disintegrating tablet. Asian J

Pharm Clin Res 2009;2(1):68-73.

Torne S, Sakarkar DM, Pawar SR, Abdul R. Fast disintegrating tablets

of ondansetron hydrochloride by direct compression technique. Int J

Pharm Tech Res 2010;2(1):433-7.

Dahima R, Sharma R. Formulation and in vitro evaluation of taste

masked orodispersible tablet of metoclopramide hydrochloride using

indion 204. Int J Chem Tech Res 2010;2(1):447-53.

Pandey S, Viral D, Manish G. Formulation and evaluation of taste

masked fast disintegrating tablets of lisinopril. Int J Pharm Tech Res

;2(2):1639-43.

Puttewar TY, Kshirsagar MD, Chandewar AV, Chikhale RV.

Formulation and evaluation of orodispersible tablet of taste masked

doxylamine succinate using ion exchange resin. J Kin Saud Univ Sci

;22(1):229-40.

Meghana SK, Krunal KV, Pravin P, Rohini PC. Development and

evaluation of mouth dissolving tablet of taste-masked amlodipine

besylate for the treatment of hypertension. Int J Pharm Chem Bio Sci

;3(1):55-62.

Remya PN, Damodharan N, Sharma L. Formulation and evaluation of

fast disintegrating orodispersible tablets of ondansetron hydrochloride.

J Pharm Sci Res 2012;4(5):1810-13.

Thakare VM, Umesh TJ, Bharat WT, Kundan PC, Piyush M.

Development of metoclopramide hydrochloride orodispersibal tablets

using taste masking tulsion 339. J Adv Pharm Educ Res 2013;3(4):480-7.

Deshmukh BA, Chaudhari SP, Jagadale S. Formulation and evaluation

of taste masked fast disintegrating tablet of tramadol HCl. Am J

Pharm Tech Res 2014;4(5):418-29.

Gupta MM, Gupta N, Chauhan BS, Pandey S. Fast disintegrating

combination tablet of taste masked levocetrizine dihydrochloride

and montelukast sodium: Formulation design, development, and

characterization. J Pharm (Cairo) 2014;2014:568320.

Tripathi GK, Mayle S. Formulation and evaluation of taste masked

orodispersible tablet of levocetirizinedihydrochloride. Bull Pharm Res

;5(1):31-4.

Published

01-05-2016

How to Cite

Singh, S., and N. Verma. “TASTE MASKED ORODISPERSIBLE TABLETS: A HIGHLY PATIENT COMPLAINT DOSAGE FORM”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 3, May 2016, pp. 385-91, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/11642.

Issue

Section

Original Article(s)