STUDY OF ANTIMICROBIAL, ANALGESIC AND ANTICONVULSANT ACTIVITY OF NOVEL ISATIN DERIVATIVES
DOI:
https://doi.org/10.22159/ajpcr.2016.v9i5.11725Abstract
Isatin is an endogenous compound and possess a wide variety of biological activities. In the present investigation, a different isatin derivatives such
as novel isatin 3-[N-(4-substituted)-hydrazinyl-3-oxo prop 1-en-2yl) benzamides and their antimicrobial, analgesic and anticonvulsant activity was
evaluated in different animal models. Antimicrobial activity by cup plate agar diffusion method. The analgesic activity was measured by Eddy's hot
plate method, and reaction time was recorded when the animals licked their for and hind paws and jumped at before 0 hr, 0.5 hr, 1 hr and 2 hrs
after administration of test drugs. 4-aminopyridine chemical induction method was employed for anticonvulsant activity. All the compounds were
screened, among the screened compounds some compounds showed antimicrobial, analgesic and anticonvulsant activity with dose-dependent effect
when compared with the control group.
Keywords: Isatin, Antibacterial, Antifungal, Analgesic, Anticonvulsant activity.
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