TOCOTRIENOL OPPOSES THE EFFECT OF LIGHT TO MODERATE ETHANOL EXPOSURES IN ELEVATED PLUS MAZE PERFORMANCE OF RATS

Authors

  • Pitchaiah Dasari Senior Research Fellow, Department of Physiology, NRI Medical College & General Hospital, Chinakakani, Mangalagiri Mandal, Guntur District, Andhra Pradesh 522503.
  • Anandamurali Rayapati Research Scholar, Department of Physiology, NRI Medical College & General Hospital, Chinakakani, Mangalagiri Mandal, Guntur District, Andhra Pradesh 522503.
  • Prasunpriya Nayak Professor, Department of Physiology, NRI Medical College & General Hospital, Chinakakani, Mangalagiri Mandal, Guntur District, Andhra Pradesh 522503.

Abstract

ABSTRACT
Objective: Tocotrienol is a naturally rare isoform of vitamin E. Consumption of ethanol is a common problem. Ethanol acts as an anxiolytic, but
hastens cognitive problems. The current study is aimed to evaluate the effect of tocotrienol against ethanol-induced cognitive and anxiolytic behavior.
Methods: Male albino Wistar rats were divided into two sets; one set of rats were exposed with low-to-moderate doses of ethanol for 4 weeks, while
another set was exposed to tocotrienol orally (10 mg/day) plus low-to-moderate doses of ethanol for 4 weeks. Performances of rats on elevated
plus maze were carried out at the end of the treatment protocol for 3 days. Video recordings were analyzed for acquisition time, retention time, and
number of entries to open arms and closed arms. Numbers of protected stretch attend posture, unprotected stretch attend posture, protected head
dipping, unprotected head dipping, grooming, rearing, paw licking, immobile sniffing, and fecal boli were also counted from the video recording.
Results: Statistically significant influences of tocotrienol and ethanol exposures have been observed in aquisition time and retention time after
24 hrs and 48 hrs, respectively. Number of exits from the closed arms and grooming and rearing behaviors also found to be significantly influenced
by tocotrienol treatment.
Conclusion: From the current study, it can be concluded that tocotrienol facilitates the explorative behaviors of control rats. In addition, the current
protocol of tocotrienol treatment opposes the ethanol-induced cognitive impairment as well as ethanol-induced anxiolytic activity in rats.
Keywords: Tocotrienol, Ethanol, Elevated plus maze, Acquisition time, Retention time, Protected stretch attend posture, Unprotected stretch attend
posture, Protected head dipping, Unprotected head dipping, Grooming, Rearing, Paw licking, Immobile sniffing.

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References

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Published

01-07-2016

How to Cite

Dasari, P., A. Rayapati, and P. Nayak. “TOCOTRIENOL OPPOSES THE EFFECT OF LIGHT TO MODERATE ETHANOL EXPOSURES IN ELEVATED PLUS MAZE PERFORMANCE OF RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 4, July 2016, pp. 122-7, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/11766.

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