ASSESSMENT OF LIPID PROFILE AND ATHEROGENIC INDICES FOR CARDIOVASCULAR DISEASE RISK BASED ON DIFFERENT FISH CONSUMPTION HABITS

Authors

  • Chandravathani Devadawson Eastern University, Sri Lanka
  • Chamila Jayasinghe Wayamba University of Sri Lanka
  • Sivakanesan Ramiah
  • Arulnithy Kanagasingam

Abstract

Objective: Habitual consumption of moderate amounts of fish is associated with reduced mortality from cardiovascular disease (CVD). However,
the beneficial effects of fish-enriched diet seem contradictory due to the oxidation susceptibility of the polyunsaturated fatty acids in them. The
atherogenic index is an important tool to identify people with CVD risk. Lipid profile levels are favorably affected by certain fish consumption habits,
thereby decreasing the risk of coronary heart diseases. The aim of this study was to evaluate the plasma lipid profile of healthy people with different
fish consumption habits and to assess CVD risk using atherogenic indices.
Methods: Fasting blood samples were collected from healthy people for lipid profile estimations with an automated analyzer. Detailed information
regarding physical and atherogenic parameters was collected from each participant.
Results: The CVD risk profiles showed varying level with the type of fish consumption. Total cholesterol, triglyceride (TG), and non-high-density
lipoprotein (Non-HDL-C) varied significantly among the types of consumers (p<0.05), whereas the high-density lipoprotein cholesterol showed
variation (p<0.001). TG/HDL showed the greater level in inland fish consumers. However, atherogenic coefficient and Castelli risk index-2 did not
show significant variation among type of fish eating. Atherogenic indices were borderline high risk†among all fish eaters including beef eating habits.
Conclusion: Fish and beef eaters had high risk among other inland and sea fish eaters. Non-HDL-cholesterol could be a marker for a serum lipid
pattern associated with increased risk of heart diseases.
Keywords: Cardiovascular diseases, Lipid profile, Fish consumption, Atherogenic indices.

Downloads

Download data is not yet available.

References

REFERENCES

Kromhout D, Bosschieter EB, de Lezenne Coulander C. The inverse

relation between fish consumption and 20-year mortality from coronary

heart disease. N Engl J Med 1985;312(19):1205-9.

Shekelle RB, Misell L, Oglesby P. Fish consumption and mortality

from cardiovascular disease. N Engl J Med 1985;313:820.

Heusten L. Global epidermic of cardiovascular disease predicted.

Lancet 1998;352(9139):1530.

Simons LA, Hickie JB, Balasubramaniam S. On the effects of dietary

n-3 fatty acids (Maxepa) on plasma lipids and lipoproteins in patients

with hyperlipidaemia. Atherosclerosis 1985;54(1):75-88.

Bass KM, Newschaffer CJ, Klag MJ, Bush TL. Plasma lipoprotein

levels as predictors of cardiovascular death in women. Arch Intern Med

;153(19):2209-16.

Kannel WB, Wilson PW. An update on coronary risk factors. Med Clin

North Am 1995;79(5):951-71.

Steinberg D. Lipoproteins and atherosclerosis. A look back and a look

ahead. Arteriosclerosis 1983;3(4):283-301.

Castelli WP, Doyle HT, Gordon T. High-density lipoprotein cholesterol

and other lipids in coronary heart disease. Circulation 1997;55:667-72.

Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP,

Knoke JD, et al. High-density lipoprotein cholesterol and

cardiovascular disease. Four prospective American studies. Circulation

;79(1):8-15.

Grundy SM, Goodman DW, Rifkind BM, Cleeman JI. The place of

high density lipoprotein in cholesterol management: A prospective

s

ns

s

ns

ns

s

s

s

s

ns

ns

from the National Cholesterol Education Program. Arch Intern Med

;149(3):505-10.

Donnan PT, Thomson M, Fowkes FG, Prescott RJ, Housley E. Diet as a

risk factor for peripheral arterial disease in the general population: The

Edinburgh Artery Study. Am J Clin Nutr 1993;57(6):917-21.

Trustwell AS. Practical and relative approaches to healthier diet

modification. Am J Clin Nutr 1998;67 3 Suppl:583S-90.

Matsuzaki T. Longevity, diet, and nutrition in Japan: Epidemiological

studies. Nutr Rev 1992;50(12):355-9.

Harris WS. N-3 fatty acids and serum lipoproteins: Human studies. Am

J Clin Nutr 1997;65 5 Suppl:1645S-54.

Nestel PJ, Connor WE, Reardon MF, Connor S, Wong S, Boston R.

Suppression by diets rich in fish oil of very low density lipoprotein

production in man. J Clin Invest 1984;74(1):82.

Illingworth DR, Harris WS, Connor WE. Inhibition of low density

lipoprotein synthesis by dietary omega-3 fatty acids in humans.

Arteriosclerosis 1984;4(3):270-5.

Sanders TA, Hinds A, Pereira CC. Influence of n-3 fatty acids on blood

lipids in normal subjects. J Intern Med Suppl 1989;731:99-104.

Bulliyya G. Fish intake and blood lipids in fish eating vs non-fish eating

communities of coastal south India. Clin Nutr 2000;19(3):165-70.

Skoczynska A. Patogeneza Miażdżycy. Wrocław: Urban&Partner;

p. 1-5.

Pasterkamp C, Falk E. Atherosclerotic plaque rupture: An overview.

J Clin Basic Cardiol 2000;3(2):81-6.

Kumar A, Nagtilak S, Sivakanesan R, Gunasekera S. Cardiovascular

risk factors in elderly normolipidemic acute myocardial infarct

patients – A case controlled study from India. Southeast Asian J Trop

Med Public Health 2009;40(3):581-92.

Ghosh J, Mishra TK, Rao YN, Aggarwal SK. Oxidised LDL, HDL

cholesterol, LDL cholesterol levels in patients of coronary artery

disease. Indian J Clin Biochem 2006;21(1):181-4.

Boyle JJ. Macrophage activation in atherosclerosis: Pathogenesis and

pharmacology of plaque rupture. Curr Vasc Pharmacol 2005;3(1):63-8.

Young IS, McEneny J. Lipoprotein oxidation and atherosclerosis.

Biochem Soc Trans 2001;29:358-62.

Bittner V. Non-HDL-cholesterol measurement, interpretation and

significance. Adv Stud Med 2007;7(1):8-11.

Liu J, Sempos C, Donahue RP, Dorn J, Trevisan M, Grundy SM. Joint

distribution of non-HDL and LDL cholesterol and coronary heart

disease risk prediction among individuals with and without diabetes.

Diabetes Care 2005;28:1916-21.

Dobiásová M. Atherogenic index of plasma [log(triglycerides/HDLcholesterol)]:

Theoretical

and

practical

implications. Clin

Chem

;50(7):1113-5.

Stampfer MJ, Sacks FM, Salvini S, Willett WC, Hennekens CH.

A prospective study of cholesterol, apolipoproteins, and the risk of

myocardial infarction. N Engl J Med 1991;325(6):373-81.

Ridker PM, Stampfer MJ, Rifai N. Novel risk factors for systemic

atherosclerosis: A comparison of C-reactive protein, fibrinogen,

homocysteine, lipoprotein(a), and standard cholesterol screening as

predictors of peripheral arterial disease. JAMA 2001;285(19):2481-5.

Brehm A, Pfeiler G, Pacini G, Vierhapper H, Roden M. Relationship

between serum lipoprotein ratios and insulin resistance in obesity. Clin

Chem 2004;50(12):2316-22.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the

concentration of low-density lipoprotein cholesterol in plasma, without

use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.

National Cholesterol Education Program. Second Report of the expert

panel on detection, evaluation and treatment of high blood cholesterol

in adults, adults treatment Panel III. Circulation 1994;89:1333-445.

Packyard CJ, Shepherd J. Lipoprotein heterogeneity and apolipoprotein

B metabolism. Arterioscler Throm Vasc Biol 1999;19:2456-64.

Brintas EA, Eaisanberg S, Breslow JL. Increased apo A-I and apo A-II

fractional catabolic rate in patients with low high density lipoproteincholesterol

levels with or without hyperglycerdima.

J

Clin

Invest

;87(2):536-44.

da Luz PL, Favarato D, Faria-Neto JR Jr, Lemos P, Chagas AC. High

ratio of triglycerides to HDL-cholesterol predicts extensive coronary

disease. Clinics (Sao Paulo) 2008;63(4):427-32.

Gaziano JM, Hennekens CH, O’Donnell CJ, Breslow JL, Buring JE.

Fasting triglycerides high-density lipoprotein and risk of myocardial

infarction. Circulation 1997;96(8):2520-5.

Bampi AB, Rochitte CE, Favarato D, Lemos PA, da Luz PL. Comparison

of non-invasive methods for the detection of coronary atherosclerosis.

Clinics (Sao Paulo) 2009;64(7):675-82.

Asian J Pharm Clin Res, Vol 9, Issue 4, 2016, 156-160

Devadawson et al.

Usoro CA, Adikwuru CC, Usoro IN, Nsonwu AC. Lipid profile of

postmenopausal women in Calabar, Nigeria. Pak J Nutr 2006;5(1):79-82.

Shimano H, Arai H, Harada-Shiba M, Ueshima H, Ohta T, Yamashita S,

et al. Proposed guidelines for hypertriglyceridemia in Japan with

non-HDL cholesterol as the second target. J Atheroscler Thromb

;15(3):116-21.

Devadawson C, Jayasinghe C, Sivakanesn R. Socio-demographic

factors and fish eating trends in Eastern community, Sri Lanka. J Exp

Biol Agric Sci 2015;3(5):423-9.

Bulliyya G, Reddy RC, Reddanna P. Traditional fish intake and

fatty acid composition in fish consuming and non-fish consuming

populations. Asia Pac J Clin Nutr 1997;6(4):230-4.

Published

01-07-2016

How to Cite

Devadawson, C., C. Jayasinghe, S. Ramiah, and A. Kanagasingam. “ASSESSMENT OF LIPID PROFILE AND ATHEROGENIC INDICES FOR CARDIOVASCULAR DISEASE RISK BASED ON DIFFERENT FISH CONSUMPTION HABITS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 4, July 2016, pp. 156-60, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/11871.

Issue

Section

Original Article(s)