HEAT SHOCK PROTEINS: KNOWLEDGE SO FAR AND ITS FUTURE PROSPECTS

Authors

  • Amarjeet Singh Lovely Professional University
  • Diksha Puri Lovely Professional University
  • Bimlesh Kumar Lovely Professional University
  • Sachin Kumar Singh Lovely Professional University

Abstract

ABSTRACT
Heat shock proteins (HSPs) are one of the most versatile classes of molecules which regulate cellular homeostasis. In 1960, Ritossa accidentally raised
the incubation temperature of Drosophila fly and found an increased gene transcription of certain unknown proteins, which he named HSPs. Further
studies explored that HSPs, being expressed at low levels under normal conditions, act as molecular chaperones, which fold, assemble, localize,
secrete, and translocate cellular proteins. Moreover, their expression is markedly induced in response to various stresses such as an exposure of
cells to heavy metals, nitric oxide, ischemia, microbial infection, antibiotics, and hormones. The literature has been thoroughly investigated, and the
present review summarizes the complex role of HSPs in gastric disorders, neurological disorders, apoptosis, cancer, etc. Expression of HSPs by cells
has important physiological or pathological implications. HSPs can be used as novel molecular targets for both the pharmacological and therapeutic
interventions to prevent and cure various diseases.
Keywords: Heat shock proteins, Apoptosis, Stress.

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Author Biographies

Amarjeet Singh, Lovely Professional University

School of Pharmaceutical Sciences, Lecturer

Diksha Puri, Lovely Professional University

School of Pharmaceutical Sciences, Lecturer

Bimlesh Kumar, Lovely Professional University

School of Pharmaceutical Sciences, Asst. Prof.

Sachin Kumar Singh, Lovely Professional University

School of Pharmaceutical Sciences, Assoc. Prof.

Published

01-08-2016

How to Cite

Singh, A., D. Puri, B. Kumar, and S. K. Singh. “HEAT SHOCK PROTEINS: KNOWLEDGE SO FAR AND ITS FUTURE PROSPECTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 7, Aug. 2016, pp. 17-24, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/12382.

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