RHODOMYRTUS TOMENTOSA: A PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i1.12773Abstract
Rhodomyrtus tomentosa is a common wood, prevalent in areas with undemanding soil conditions and resistant toward pests and diseases. The plant can be found in China, Taiwan, Philippines, Malaysia, Indonesia, and Vietnam. Literature and artwork indicate that R. tomentosa played an important holistic role in the daily lives of several ancient cultures, providing medicinal benefits. R. tomentosa exhibits a wide spectrum of pharmacological effects and has been used to treat colic diarrhea, wounds, heartburn, abscesses, gynecopathy, and as a pain killer. R. tomentosa was used in traditional Chinese medicine to treat urinary tract infection. 42 compounds have been isolated from this plant and structurally elucidated. They comprise phloroglucinol, flavonoid, terpenoid, anthracene glycoside, tannin, and other compounds. Rhodomyrtone, a member of the acylphloroglucinols demonstrated a significant activity against a wide range of Gram-positive bacteria. Rhodomyrtone exhibited both antimicrobial and anti-infective activities. Several biological activities have been documented as antibacterial, antifungal, antimalarial, osteogenic, antioxidant, and anti-inflammatory. R. tomentosa has been studied extensively for alternative antimicrobial agents. Although rhodomyrtone exhibited potential activity with a very low minimum inhibitory concentration value, the mechanisms of action of this compound are still unclear. Furthermore, toxicity studies on it extract to validate pharmacological activities are required.
Keywords: Rhodomyrtus tomentosa, Kemunting, Phytochemical, Pharmacological, Biological activities, Chemical constituents.
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Cos P, Vlietinck AJ, Berghe DV, Maes L. Anti‑infective potential of natural products: How to develop a stronger in vitro proof‑of‑conceptâ€. J Ethnopharmacol 2006;106:290‑302.
Bernhoft A. A brief review on bioactive compounds in plants. Bioactive
Compounds in Plants‑Benefits and Risks for Man and Animals. Oslow, Norway: The Norwegian Academy of Science and Letters; 2010. p. 11‑7.
Sasidharan S, Chen Y, Saravanan D, Sundram K, Latha LY. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. African Journal of Tradit Complement Altern Med 2011;8(1):1‑10.
Do T. Medicine Plants and Remedies of Vietnam. Hanoi: Thoi Dai publisher; 2011.
Limsuwan S, Trip EN, Kouwen TR, Piersma S, Hiranrat A, Mahabusarakam W, et al. Rhodomyrtone: A new candidate as natural antibacterial drug from Rhodomyrtus tomentosa. Phytomedicine 2009;16(6):645‑51.
Winotai A, Wright T, Goolsby JA. Herbivores in Thailand onRhodomyrtus tomentosa (Myrtaceae), an invasive weed in Florida. Fla Entomol 2005;88(1):104‑5.
Lai TN, André C, Rogez H, Mignolet E, Nguyen TB, Larondelle Y. Nutritional composition and antioxidant properties of the sim fruit (Rhodomyrtus tomentosa). Food Chem 2015;168:410‑6.
Lim T. Rhodomyrtus tomentosa. Edible medicinal and non medicinal plants. New York: Springer; 2012. p. 732‑7.
Maskam MF. Antioxidant Effects of Rhodomyrtus tomentosa (Kemunting) Extract on the Development of Experimental Atherosclerotic‑Induced New Zealand White Rabbit. University of
Malaya; 2011.
Langeland KA. Identification and Biology of Nonnative Plants in Florida’s Natural Areas. Gainesville, FL: IFAS Communication Services, University of Florida; 2008.
Latiff A. Rhodomyrtus tomentosa (Aiton) Hassk. Plant Resources of South‑East Asia No. 2. Bogor: Prosea; 1992. p. 276‑7.
Arya V. A review on anti‑tuberculosis plants. Int J PharmTech Res 2011;3(2):872‑80.
Ong H, Nordiana M. Malay ethno‑medico botany in Machang, Kelantan, Malaysia. Fitoterapia 1999;70(5):502‑13.
Wei F. Manufacture of Oral Liquid Containing Traditional Chinese Medicine Extract for Treating Gynecopathy (Guangxi Huahong Pharmaceutical Co., Ltd., People’s Republic of China; Shanghai Fosun
Pharmaceutical (Group) Co., Ltd.), Faming Zhuanli Shenqing Gongkai Shuomingshu. People’s Republic of China Patent CN1846715; 2006.
Chuakul W. Medicinal plants in the Khok Pho district, pattani province (Thailand). Thai J Phytopharm 2005;12:23‑45.
Jeong D, Yang WS, Yang Y, Nam G, Kim JH, Yoon DH, et al. In vitro and in vivo anti‑inflammatory effect of Rhodomyrtus tomentosa methanol extract. J Ethnopharmacol 2013;146(1):205‑13.
Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem 2004;52(12):4026‑37.
Lai TN, Herent MF, Quetin‑Leclercq J, Nguyen TB, Rogez H, Larondelle Y, et al. Piceatannol, a potent bioactive stilbene, as major phenolic component in Rhodomyrtus tomentosa. Food Chem
;138(2‑3):1421‑30.
Cui C, Zhang S, You L, Ren J, Luo W, Chen W, et al. Antioxidant capacity of anthocyanins from Rhodomyrtus tomentosa (Ait.) and identification of the major anthocyanins. Food Chem 2013;139(1‑4):1‑8.
Liu GL, Guo HH, Sun YM. Optimization of the extraction of anthocyanins from the fruit skin of Rhodomyrtus tomentosa (Ait.) Hassk and identification of anthocyanins in the extract using high‑
performance liquid chromatography‑electrospray ionization‑mass spectrometry (HPLC‑ESI‑MS). Int J Mol Sci 2012;13(5):6292‑302.
Wu P, Ma G, Li N, Deng Q, Yin Y, Huang R. Investigation of in vitro and in vivo antioxidant activities of flavonoids rich extract from the berries of Rhodomyrtus tomentosa (Ait.) Hassk. Food Chem
;173:194‑202.
Tung NH, Ding Y, Choi EM, Van Kiem P, Van Minh C, Kim YH. New anthracene glycosides from Rhodomyrtus tomentosa stimulate osteoblastic differentiation of MC3T3‑E1 cells. Arch Pharm Res
;32(4):515‑20.
Hiranrat A, Mahabusarakam W. New acylphloroglucinols from the leaves of Rhodomyrtus tomentosa. Tetrahedron 2008;64(49):11193‑7.
Hiranrat A, Mahabusarakam W, Carroll AR, Duffy S, Avery VM. Tomentosones A and B, hexacyclic phloroglucinol derivatives from the Thai shrub Rhodomyrtus tomentosa. J Org Chem 2011;77(1):680‑3.
Salni D, Sargent MV, Skelton BW, Soediro I, Sutisna M, White AH, et al. Rhodomyrtone, an antibotic from Rhodomyrtus tomentosa. Aust J Chem 2002;55(3):229‑32.
Hiranrat A, Chitbankluoi W, Mahabusarakam W, Limsuwan S, Voravuthikunchai S.Anew flavellagic acid derivative and phloroglucinol from Rhodomyrtus tomentosa. Nat Prod Res 2012;26(20):1904‑9.
Fahmi R, Sargent M, Skelton B, White A. 5-Hydroxy-3, 3′, 4′, 5′, 7‑pentamethoxyflavone (combretol). Acta Crystallogr Sect E Struct Rep Online. 2004;60(1):86‑8.
Hou A, Wu Y, Liu Y. Flavone glycosides and an ellagitannin from downy rosemyrtle (Rhodomytus tomentosa). Chin Tradit Herb Drugs 1999;30:645‑7.
Hui WH, Li MM, Luk K. Triterpenoids and steroids from Rhodomyrtus tomentosa. Phytochemistry 1975;14(3):833‑4.
Wai‑Haan H, Man‑Moon L. Two new triterpenoids from Rhodomyrtus tomentosa. Phytochemistry 1976;15(11):1741‑3.
Liu Y, Hou A, Ji C, Wu Y. Isolation and structure of hydrolysable tannins from Rhodomyrtus tomentosa. Natl Prod Res Dev 1997;10(1):14‑9.
Limsuwan S, Hesseling‑Meinders A, Voravuthikunchai SP, Van Dijl JM, Kayser O. Potential antibiotic and anti‑infective effects of rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. on Streptococcus pyogenes as revealed by proteomics. Phytomedicine 2011;18(11):934‑40.
Saising J, Hiranrat A, Mahabusarakam W, Ongsakul M, Voravuthikunchai SP. Rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. as a natural antibiotic for staphylococcal cutaneous
infections. J Health Sci 2008;54(5):589‑95.
Saising J, Voravuthikunchai SP. Anti Propionibacterium acnes activity of rhodomyrtone, an effective compound from Rhodomyrtus tomentosa (Aiton) Hassk. leaves. Anaerobe 2012;18(4):400‑4.
Voravuthikunchai SP, Dolah S, Charernjiratrakul W. Control of Bacillus cereus in foods by Rhodomyrtus tomentosa (Ait.) Hassk. leaf extract and its purified compound. J Food Prot2010;73(10):1907‑12.
Limsuwan S, Kayser O, Voravuthikunchai SP. Antibacterial activity of Rhodomyrtus tomentosa (Aiton) Hassk. leaf extract against clinical isolates of Streptococcus pyogenes. Evid Based Complement Alternat Med 2012;2012:697183.
Saising J, Ongsakul M, Voravuthikunchai SP. Rhodomyrtus tomentosa (Aiton) Hassk. ethanol extract and rhodomyrtone: A potential strategy for the treatment of biofilm‑forming staphylococci. J Med Microbiol 2011;60(12):1793‑800.
Leejae S, Hasap L, Voravuthikunchai SP. Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus by rhodomyrtone, a novel antibiotic candidate. J Med Microbiol 2013;62(3):421‑8.
Jeenkeawpieam J, Phongpaichit S, Rukachaisirikul V, Sakayaroj J. Antifungal activity and molecular identification of endophytic fungi from the angiosperm Rhodomyrtus tomentosa. Afr J Biotechnol
;11(75):14007‑16.
Plodpai P, Petcharat V, Chuenchit S, Chakthong S, Joycharat N, Voravuthikunchai SP. Desmos chinensis: A new candidate as natural antifungicide to control rice diseases. Ind Crops Prod 2013;42:324‑31.
Lavanya G, Voravuthikunchai SP, Towatana NH. Acetone extract from Rhodomyrtus tomentosa: A potent natural antioxidant. Evid Based Complement Alternat Med 2012;2012:535479.
Geetha K, Sridhar C, Murugan V. Antioxidant and healing effect of aqueous alcoholic extract of Rhodomyrtus tomentosa (Ait.) Hassk on chronic gastric ulcers in rats. J Pharm Res 2010;3(12):2860‑2.
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