ASSESSMENT OF MICROALBUMINURIA IN ESSENTIAL HYPERTENSIVES AND ITS RESPONSE TO ANGIOTENSIN-CONVERTING ENZYME INHIBITOR THERAPY

Preeti Sharma; Pradeep Kumar; Rachna Sharma; Tripathi Gk; Gaurav Gupta

doi:10.22159/ajpcr.2016.v9s3.13618

Authors

Preeti Sharma
Pradeep Kumar Santosh University
Rachna Sharma
Tripathi Gk
Gaurav Gupta

DOI:

https://doi.org/10.22159/ajpcr.2016.v9s3.13618

Abstract

ABSTRACT
Objective: Objective is to study the prevalence of microalbuminuria among patients suffering from essential hypertension and also to evaluate the
response of microalbuminuria to angiotensin-converting enzyme (ACE) inhibitors therapy.
Methods: The study conducted at Santosh Medical College and Hospital, Ghaziabad, on 300 patients with essential hypertension. After attaining
baseline parameters in all patients, those newly diagnosed essential hypertensives with microalbuminuria not on any treatment were started on an
ACE inhibitor (ramipril), for 8 weeks, after which all parameters were reassessed and comparison and statistical analysis were done to establish the
prevalence of microalbuminuria and its response to therapy.
Results: In our study, mean microalbuminuria excretion was 101.79 mcg/mg creatinine at the beginning of the study and 80.20 mcg/mg creatinine
after 8 weeks of ACE inhibitor therapy, with 21.2% fall rate.
Conclusion: Microalbuminuria is an independent risk factor for the development or worsening of hypertensive nephropathy and endothelial
dysfunction, thereby increasing the risk of micro- and macro-vascular complications.
Keywords: Microalbuminuria, Essential hypertension, Angiotensin-converting enzyme inhibitor therapy.

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Author Biography

Pradeep Kumar, Santosh University

Professor of Biochemistry

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