EVALUATION OF THE GENOTOXICITY OF ESSENTIAL OIL FROM ORIGANUM COMPACTUM BENTH. IN HUMAN LYMPHOCYTES
DOI:
https://doi.org/10.22159/ajpcr.2016.v9s2.13743Abstract
ABSTRACT
Objective: Essential oils with antimicrobial and antioxidant activities have gained importance. This study was conducted to investigate the genotoxic
potential of the essential oil of Origanum compactum.
Methods: Micronucleus test and proliferation index (PI) were used to evaluate the genotoxic effect of the essential oil of O. compactum on human
lymphocytes.
Results: The results demonstrated that the PI values were influenced by the tested essential oil. An increase in concentration of essential oil also
caused the appearance of micronuclei.
Conclusion: The results of the present work suggest that O. compactum essential oil exhibited genotoxic activity at higher concentration. Further
studies are necessary to confirm these findings.
Keywords: Origanum compactum, Human lymphocytes, Proliferation index, Micronucleus test.
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