EFFECT OF SARGASSUM ILICIFOLIUM ON OVOGENESIS IN PCOS INDUCED RATS

Anbu J; Sukanya K; Santhosh Kumar S; Ramya PS Reddy; Vani B Nandihalli

doi:10.22159/ajpcr.2016.v9i6.13837

Authors

Anbu J Department of Pharmacology, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bangalore-560054
Sukanya K Department of Pharmacology, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bangalore-560054
Santhosh Kumar S Department of Pharmacology, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bangalore-560054
Ramya PS Reddy Department of Pharmacology, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bangalore-560054
Vani B Nandihalli Department of Pharmacology, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bangalore-560054

DOI:

https://doi.org/10.22159/ajpcr.2016.v9i6.13837

Abstract

Objective: This study was conducted to evaluate the effect of Sargassum ilicifolium (S. ilicifolium) on Testosterone induced Polycystic Ovary Syndrome (PCOS) in rats.

Methods: Female Wistar albino rats were divided into 6 groups consisting of 6 rats each. PCOS was induced in all the animals except normal group on administration of Testosterone (2 mg/100 g) for 21 d daily. After PCOS induction the standard group rats were treated with Clomiphene citrate (CC) (1 mg/kg p.o.). The test groups were treated with 100, 200 and 400 mg/kg of ethanolic extract of Sargassum ilicifolium (EESI) orally and normal animals were administered 2% CMC (2 ml/kg) respectively for 21 d. During induction and treatment period various parameters like oestrus cycle, histopathology, hormonal and biochemical assays have been evaluated. Further to confirm the enhanced fertility rate, the rats were mated and the litter size was observed.

Results: The results revealed the normalcy in oestrus cycle, hormonal, biochemical and histopathological parameters. The litter size was increased significantly compared to control.

Conclusion: Overall, from the obtained results it is determined that the S.Â ilicifolium exhibited a good anti-androgenic effect by reducing the Testosterone levels in PCOS induced conditions.

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Author Biography

Anbu J, Department of Pharmacology, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bangalore-560054

Department of Pharmacology, Faculty of Pharmacy, M.S.Ramaiah University of Applied Sciences, MSR Nagar, Bangalore-560054

Rank: B

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