SYNTHESIS, CHARACTERIZATION OF MANNICH BASE TRANSITION METAL COMPLEXES: DNA BINDING AND ANTI BACTERIAL STUDIES

Authors

  • Sivakami M SRM UNIVERSITY, KATTANKULATHUR,CHENNAI
  • Natarajan B
  • Vijayachandrasekar M

Abstract

 

 Objective: Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important biological and pharmaceutical interest.

Methods: The novel mannich base 1-((2,5-dioxopyrrolidin-1-yl)(4-methoxyphenyl)methyl)thiourea succinimide, methoxy benzaldehyde and thiourea (SMBTU) has been synthesized in good yield by condensation of equimolar quantities of SMBTU. manganese (II), cobalt (II), nickel (II) and copper (II) complexes of the above ligand have also been synthesized.

Results: Structures of newly synthesized compounds were confirmed by elemental analysis, infrared, ultraviolet-visible and nuclear magnetic resonance. All the complexes adopt octahedral geometry around the metal ions. All the newly synthesized compounds were screened for their anti-microbial activity against Escherichia coli and Bacillus subtilis bacteria by minimal inhibitory concentration technique. The binding of the cobalt chloride complex of the ligand with calf thymus DNA has been investigated using absorption spectroscopy, fluorescence spectroscopy and viscosity measurements.

Conclusion: All the complexes exhibit octahedral geometry. The ligand and its metal complexes have shown significant antibacterial activity. The Co (II) metal complex showed efficient DNA binding ability and the binding constant value is consistent with other typical intercalators.

Keywords: Mannich base, Metal complexes, Anti-bacterial, DNA binding, Fluorescence and Viscosity measurements

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Author Biography

Sivakami M, SRM UNIVERSITY, KATTANKULATHUR,CHENNAI

Assistant Professor,

Department of Chemistry,

Faculity of Engg & Technology,

SRM University. Chennai. 

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Published

01-11-2014

How to Cite

M, S., N. B, and V. M. “SYNTHESIS, CHARACTERIZATION OF MANNICH BASE TRANSITION METAL COMPLEXES: DNA BINDING AND ANTI BACTERIAL STUDIES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 211-5, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/1448.

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