ENTERAL/ORAL GLUTAMINE SUPPLEMENTATION IN PATIENTS FOLLOWING SURGERY AND ACCIDENTAL INJURY

Vijey Aanandhi M; Meha Rachel John

doi:10.22159/ajpcr.2017.v10i3.16569

Authors

Vijey Aanandhi M
Meha Rachel John vels university,chennai,india

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i3.16569

Abstract

ABSTRACT
Objective: The objective of this investigation was to study the effect of enteral/oral glutamine supplementation in patients following abdominal
surgery on plasma glutamine levels, rate of infection, and length of hospitalization (LOH).
Methods: A randomized control trial was used, and the patients were randomly divided into two groups, namely experimental and control with
30 participants each. Glutamine supplement (0.5 g/kg) was administered (oral and enteral) to the experimental group for 5 days post-surgery
immediately after the feeding began. The study was conducted in ESIC hospital, Chennai, India.
Results: The incidence of infection in the control group was found to be almost twice that in the experimental group considering the role of glutamine
in combating infection. Furthermore, the LOH was found to be slightly higher in the control group as compared to the experimental group.
Conclusion: This study has provided evidence that the supplementation of enteral glutamine in post-operative patients decreases the incidence of
post-surgical infection, shortening of hospital stay and reduction in the overall hospital costs.
Keywords: Glutamine supplementation, Post-operative patients, Oral and enteral feed.

Downloads

Download data is not yet available.

Author Biography

Meha Rachel John, vels university,chennai,india

pharm D,5th yr student

References

REFERENCES

Hiram SO. Percentage of weight loss basic indicator of surgical risk in patients with chronic peptic ulcer. J Am Med Assoc 1936;106:458-60.

MacFie JO, Boyle C, Mitchell CJ, Buckley PM, Johnstone D, Sudworth P. Gut origin of sepsis: A prospective study investigating associations between bacterial translocation, gastric microflora and septic morbidity. Gut 1999;45:223-8.

van der Hulst RR, von Meyenfeldt MF, van Kreel BK, Thunnissen FB, Brummer RJ, Arends JW, et al. Gut permeability, intestinal morphology, and nutritional depletion. Nutrition 1998;14:1-6.

Beattie AH, Prach AT, Baxter JP, Pennington CR. A randomized controlled trial evaluating the use of enteral nutritional supplements postoperatively in malnourished surgical patients. Gut 2000;46:813-8.

Kratzing C. Pre-operative nutrition and carbohydrate loading. Proc Nutr Soc 2011;70:311-5.

Beier-Holgersen R, Boesby S. Influence of postoperative enteral nutrition on postsurgical infections. Gut 1996;39:833-5.

Sodergren MH, Jethwa P, Kumar S, Duncan HD, John T, Pearce CB. Immuno nutrition in patients undergoing major upper gastrointestinal surgery: A prospective double-blind randomized controlled study. Scand J Surg 2010;99:153-61.

FÃ¼rst, P, Stehle P. Glutamine supplemented nutrition in clinical practice and use of glutamine-containing dipeptides. Infusionsther Transfusionsmed 1995;22:317-24.

Morlion BJ, Stehle P, Wachtler P, KÃ¶ller M, KÃ¶nig W, FÃ¼rst P, et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: A randomized, double-blind, controlled study. Ann Surg 1998;227:302-8.

Lin MT, Kung SP, Yeh SL, Liaw KY, Wang MY, Kuo ML, et al. Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity. World J. Gastroenterol 2005;11:6197-201.

Ward N. Nutrition support to patients undergoing gastrointestinal surgery. Nutr J 2003;2:18.

Jian ZM, Cao JD, Zhu XG, Zhao WX, Yu JC, Ma EL, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: A randomized, double-blind, controlled study of 120 patients. J Parenter Enteral Nutr 1999;23:S62-6.