OPTIC NEUROPATHY INDUCED BY LOW DOSE OF ETHAMBUTOL: A RARE PRESENTATION

Krishna Rao Addoor; Vuppalapati Nishant Janardhana Raju; Sulatha V Bhandary; Sudha Girish Menon; Aakanksha Gupta

doi:10.22159/ajpcr.2017.v10i4.16983

Authors

Krishna Rao Addoor Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.
Vuppalapati Nishant Janardhana Raju Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.
Sulatha V Bhandary Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.
Sudha Girish Menon Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.
Aakanksha Gupta Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i4.16983

Abstract

Ethambutol is a bacteriostatic antimicrobial agent used in the treatment of tuberculosis. Optic neuropathy is a potentially severe side effect of ethambutol, which is dose related. Ethambutol-induced optic neuropathy (EON) incidence is 15%, 5% & 1% when taken at 50 mg/kg/day , 25 mg/kg/day & 15 mg/kg/day respectively for 3 months. We report a case of bilateral EON in 20-year-old female after 1 month of exposure to 15 mg/kg/day of ethambutol for tubercular meningitis. Ophthalmologic examination revealed bilateral ill sustained pupillary reactions and optic disc pallor. Deranged color vision test and scotomas on Goldmann perimetry in both eyes, aided in diagnosis.

Keywords: Low dose ethambutol, Optic neuropathy, Tuberculosis.

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Author Biographies

Krishna Rao Addoor, Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.

DEPARTMENT OF OPHTHALMOLOGY, PROFESSOR

Vuppalapati Nishant Janardhana Raju, Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.

DEPARTMENT OF OPHTHALMOLOGY, JUNIOR RESIDENT

Sulatha V Bhandary, Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.

DEPARTMENT OF OPHTHALMOLOGY, PROFESSOR

Sudha Girish Menon, Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.

DEPARTMENT OF OPHTHALMOLOGY, ASSISTANT PROFESSOR

Aakanksha Gupta, Department of ophthalmology, kasturba medical college, manipal university, manipal, india-576104.

DEPARTMENT OF OPHTHALMOLOGY, JUNIOR RESIDENT

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