EVALUATION OF ANTI-DIABETIC ACTIVITY OF HYDNOCARPUS LAURIFOLIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS.

Authors

  • Sailaja Rao P JNTUH University
  • Krishna Mohan G
  • Prathima Srinivas

Abstract

Objective: The objective of this study was to evaluate the anti-hyperglycemic activity of different extracts of Hydnocarpus laurifolia seeds in both normal and diabetic rats.

Methods: Male Wistar rats weighing about 180-250 g were taken and divided into eleven groups, with six rats in each group. Diabetes was induced by giving streptozotocin (30-50 mg/kg) intraperitoneally. Rats that showed blood glucose levels >250 mg/dl were selected for the study. Metformin (50 mg/kg) was given as a standard oral hypoglycemic agent. Oral glucose tolerance test was performed in all groups of rats.

Results: The petroleum ether and ethylacetate extracts of H. laurifolia seeds at different doses was prepared and administered orally. The blood glucose levels were estimated by glucose-oxidase method. Anti-hyperglycemic activity of the test drugs in diabetic rats showed a significant reduction in blood glucose levels (p<0.0001) at 1 hr, 2 hr and 4 hrs respectively when compared to diabetic group.

Conclusion: The results suggested that H. laurifolia seed extract may have potent anti-diabetic activity, justifying the use of the drug for the treatment of diabetes mellitus.

Keywords: Hydnocarpus laurifolia, Achariaceae, Oral glucose tolerance test, Anti-hyperglycemic activity

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Published

01-11-2014

How to Cite

Rao P, S., K. Mohan G, and P. Srinivas. “EVALUATION OF ANTI-DIABETIC ACTIVITY OF HYDNOCARPUS LAURIFOLIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 62-64, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/1708.

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