MYXEDEMA MADNESS: AN INTRIGUING CASE OF DEPRESSION IN HYPOTHYROIDISM

Navin Patil; Karthik Rao; Humeera Naaz; Balaji Ommurugan; Gayathri Baiju; Ananda Naik; Hargun Singh Sira

doi:10.22159/ajpcr.2017.v10i8.19081

Authors

Navin Patil Assistant Professor, Department of Pharmacology, Kasturba Medical College, Manipal university, Manipal.
Karthik Rao Assistant Professor, Department of General Medicine, Kasturba Medical College, Manipal university, Manipal.
Humeera Naaz Department of General Medicine, Kasturba Medical College, Manipal university, Manipal.
Balaji Ommurugan Post graduate , Department of Pharmacology, Kasturba Medical college , Manipal university , Manipal.
Gayathri Baiju Department of General Medicine, Kasturba Medical College, Manipal university, Manipal.
Ananda Naik Department of General Medicine, Kasturba Medical College, Manipal university, Manipal.
Hargun Singh Sira undergraduate, Kasturba Medical College, Manipal university, Manipal.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i8.19081

Keywords:

Hypothyroidism, Psychosis, Affective disorder, Levothyroxine

Abstract

Hypothyroidism is a clinical syndrome due to deficiency of thyroid hormone. Thyroid hormone is responsible for maintaining the brain hemostasis and helps in central nervous system global development. There have been studies on the association of psychiatric illness with thyroid deficiency and strikingly found to be presenting feature of hypothyroidism in many patients. Literature evidence also says that underlying hypothyroidism may leadÂ to failure of psychiatric treatment. Hence, we report a case of hypertensive patient on medications started with antidepressants and antipsychoticsÂ after being diagnosed of depression but was found to be resistant to psychiatric medications and later successfully treated with levothyroxine forÂ underlying hypothyroidism with myxedema.

Downloads

Download data is not yet available.

References

Rita JA, Nambi S. A case of hypothyroidism induced recurrent depressive disorder. Int J Pharm Pharm Sci 2015;7(11):397-8.

Pomeranze J, King EJ. Psychosis as first sign of thyroid dysfunction. Geriatrics 1966;21(6):211-2.

Thompson CC, Potter GB. Thyroid hormone action in neural development. Cereb Cortex 2000;10(10):939-45.

Dratman MB. Cerebral versus peripheral regulation and utilization of thyroid hormones. In: Joffe RT, Levitt AJ, editors. The Thyroid Axis and Psychiatric Illness. Washington, DC: American Psychiatric Press, Inc.; 1993. p. 3-94.

Ruel J, Faure R, Dussault JH. Regional distribution of nuclear T3 receptors in rat brain and evidence for preferential localization in neurons. J Endocrinol Invest 1985;8(4):343-8.

Hall RC. Psychiatric effects of thyroid hormone disturbance. Psychosomatics 1983;24(1):7-11, 15-8.

Pies RW. Women, mood, and the thyroid. Women Psychiatry Health 1995;4:4-10.

Howland RH. Thyroid dysfunction in refractory depression: Implications for pathophysiology and treatment. J Clin Psychiatry 1993;54(2):47-54.

Cleare AJ, McGregor A, Oâ€™Keane V. Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression. Clin Endocrinol (Oxf) 1995;43(6):713-9.

Chari S. The lesson from a yellow psychotic patient. Hosp Med 2002;63(6):370-1.