SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF 1-(4-METHYL-6-NITRO-2H-BENZO[B] [1,4]THIAZINE-3(4H)-YLIDENE)HYDRAZINE-1,1-DIOXIDE DERIVATIVES

Monika Maheshwari; Anju Goyal

doi:10.22159/ajpcr.2017.v10i9.19093

Authors

Monika Maheshwari Department of Pharmaceutical Chemistry, B N Institute of Pharmaceutical Sciences, Sevashram, Udaipur, Rajasthan, India.
Anju Goyal Department of Pharmaceutical Chemistry, B N Institute of Pharmaceutical Sciences, Sevashram, Udaipur, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i9.19093

Keywords:

1, 4-Benzothiazines, Sulfones, Hydrazines, Antimicrobial activity

Abstract

Â

Â Objective: The objective of this work was to synthesize and evaluate antimicrobial properties of 1-(4-methyl-6-nitro-2H-benzo[b][1,4]thiazine- 3(4H)-ylidene)hydrazine-1,1-dioxide derivatives.

Methods: These new compounds were synthesized by methylation in 4-N and reacted with hydrazine derivatives and oxidized at the sulfur atom by 30% hydrogen peroxide to obtain sulfones. All the synthesized compounds were evaluated for antimicrobial activity using the disc diffusion method.

Results: The Fourier transform infrared, 1H nuclear magnetic resonance (NMR), 13CNMR, and mass studies confirm the synthesis of some new 1-(4-methyl- 6-nitro-2H-benzo[b][1,4]thiazine-3(4H)-ylidene)hydrazine-1,1-dioxide derivatives. Compound 6f showed the potent antimicrobial activity.

Conclusion: Result obtained in this research work clearly indicated that the compound 6f having methyl at 2 position and nitro groups at 2â€² and 4â€² position showed the most potent antimicrobial activity.

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