CLINICAL MANIFESTATIONS OF JUVENILE IDIOPATHIC ARTHRITIS IN TAMILNADU
Abstract
Â
 Objective: The objective was to study the functional disability, and clinical manifestations in children diagnosed with juvenile idiopathic arthritis (JIA) in Bhavani town, Tamil Nadu. JIA is a mixed group of disorders among various populations with various clinical manifestations. We have carried out a study herein the data presented.
Methods: Patient's diagnosis of arthritis with an age group of 10-15 years presenting to tertiary care hospital, Bhavani town, Tamil Nadu for a period of 4 months in the year of 2013-2014. A retrospective study have been conducted and reclassified as JIA based on the International League of Association for Rheumatology (ILAR) JIA diagnostic criteria.
Results: Totally 45 patients with arthritis at age of 10-15 years were evaluated during a period of 6 months at the hospital. These patients were further analyzed by ILAR JIA criteria. Average age of disease onset among 15 patients (33.33%) were 6 years with an average age at first visit to the hospital being 7 years and with a male to female ratio of 2:4. Polyarticular rheumatoid factor (RF) negative JIA, at 44.5% was the most frequent type of chronic arthritis encountered. 4.5% polyarticular RF was positive and JIA. 17.7% diagnoses with psoriatic arthritis among the population.
Conclusion: Polyarticular RF negative which was the subtype in JIA was found to be high at Bhavani town, Tamil Nadu. There is a need to elucidate environmental factors of JIA in this region.
Keywords: Juvenile idiopathic arthritis, Bhavani town, Clinical manifestations, International League of Association for Rheumatology, Rheumatoid factor.
Downloads
References
Cassidy JT, Petty RE. Textbook of Pediatric Rheumatology. New York: WB Saunders; 1995.
Thompson SD, Murray KJ, Grom AA, Passo MH, Choi E, Glass DN. Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: Evidence for antigenic selection of T cells in the synovium. Arthritis Rheum 1998;41(3):482-97.
Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: Second revision, Edmonton, 2001. J Rheumatol 2004;31(2):390-2.
Fink CW. Proposal for the development of classification criteria for idiopathic arthritides of childhood. J Rheumatol 1995;22(8):1566-9.
Haffejee IE, Raga J, Coovadia HM. Juvenile chronic arthritis in black and Indian South African children. S Afr Med J 1984;65(13):510-4.
Petty RE, Southwood TR, Baum J, Bhettay E, Glass DN, Manners P, et al. Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol 1998;25(10):1991-4.
Haas JP, Kimura A, Truckenbrodt H, Suschke J, Sasazuki T, Volgger A, et al. Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter. Tissue Antigens 1995;45(5):317-21.
Haas JP, Frank C, Haefner R, Spath H, Leipold G, Wassmuth R, et al. Inversion of MHC-class II transcription levels in joints of children with EOPA-JCA [abstract]. Arthritis Rheum 1998;41(9):83.
McDowell TL, Symons JA, Ploski R, Førre O, Duff GW. A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 alpha polymorphism. Arthritis Rheum 1995;38(2):221-8.
Maksymowych WP, Gabriel CA, Luyrink L, Melin-Aldana H, Elma M, Giannini EH, et al. Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset. Immunogenetics 1992;35(4):257-62.
Cassidy JT, Petty RE, Sullivan DB. Occurrence of selective IgA deficiency in children with juvenile rheumatoid arthritis. Arthritis Rheum 1977;20:181-3.
Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P. Polymorphic haplotypes of the interleukin-10 5’ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 1999;42(6):1101-8.
Woo P, O’Brien J, Robson M, Ansell BM. A genetic marker for systemic amyloidosis in juvenile arthritis. Lancet 1987;2(8562):767-9.
Arnaud P, Galbraith RM, Faulk WP. Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis. J Clin Invest 1977;60(6):1442-4.
Glass D, Litvin D, Wallace K, Chylack L, Garovoy M, Carpenter CB, et al. Early-onset pauciarticular juvenile rheumatoid arthritis associated with human leukocyte antigen-DRw5, iritis, and antinuclear antibody. J Clin Invest 1980;66(3):426-9.
Epplen C, Rumpf H, Albert E, Haas P, Truckenbrodt H, Epplen JT. Immunoprinting excludes many potential susceptibility genes as predisposing to early onset pauciarticular juvenile chronic arthritis except HLA class II and TNF. Eur J Immunogenet 1995;22(4):311 22.
Sullivan KE, McDonald-McGinn DM, Driscoll DA, Zmijewski CM, Ellabban AS, Reed L, et al. Juvenile rheumatoid arthritis-like polyarthritis in chromosome 22q11.2 deletion syndrome (DiGeorge anomalad/velocardiofacial syndrome/conotruncal anomaly face syndrome). Arthritis Rheum 1997;40(3):430-6.
Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102(7):1369-76.
Adams BS, Tan H, Markovitz DM. Allele-specific DQA1 promoter binding by DEK, a putative autoantigen in juvenile rheumatoid arthritis. Arthritis Rheum 1998;41 Suppl 9:S188.
Chipeta J, Njobvu P, Wa-Somwe S, Chintu C, McGill PE, Bucala R. Clinical patterns of juvenile idiopathic arthritis in Zambia. Pediatr Rheumatol Online J 2013;11(1):33.
Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet 2007;369(9563):767-78.
Yilmaz M, Kendirli SG, Altintas DU, Karakoc GB, Inal A, Kilic M. Juvenile idiopathic arthritis profile in Turkish children. Pediatr Int 2008;50(2):154-8.
Kunjir V, Venugopalan A, Chopra A. Profile of Indian patients with juvenile onset chronic inflammatory joint disease using the ILAR classification criteria for JIA: A community-based cohort study. J Rheumatol 2010;37(8):1756-62.
Azam S, Dipti T, Rahman S. Prevalence and clinical pattern of juvenile idiopathic arthritis in a semi-urban area of Bangladesh. Int J Rheum Dis 2012;15(1):116-20.
Lowe RF. The distribution of the blood groups and HLA antigens of Zimbabwe Africans. Cent Afr J Med 1981;27 11 Suppl:1-18.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.