HERBAL CONTRACEPTIVES: EVALUATION OF ANTIFERTILITY POTENTIAL OF HIBISCUS ROSA‑SINENSIS (LINN.)

Authors

  • Shikha Baghel Chauhan Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida - 201 301, Uttar Pradesh, India.
  • Tanveer Naved Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida - 201 301, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i11.20531

Keywords:

Contraceptive, Herbal, Hibiscus rosa-sinensis L, Antifertility

Abstract

This review explores, evaluates, and analyzes the contraceptive potential of Hibiscus rosa-sinensis L. There are large numbers of synthetic contraceptives available in the market. These synthetic contraceptives are associated with many side effects ranging from user discomfort to toxicity. India is a land of traditional herbal medicines. People are finding and exploring the advantages associated with herbal contraceptives because of their lower side effects. Herbal contraceptives have lower cost of development as compared to modern medicine. This review explores the recent advances in development that offers many benefits for shifting the paradigm for herbal contraceptives. From times immemorial, references have been made for the plants that possess antifertility properties. This review explores the need for the development of herbal contraceptives from the plant H. rosa-sinensis L. H. rosa-sinensis L is reported to have antiovulatory activity. However, the need of the hour is to assess and carry out toxicological studies and initiate development activity for formulation development.

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References

Davis K, Blake J. Social structure and fertility: An analytical framework. Econ Cult Change 1956;4:211-35.

Bongaarts J. A framework for analysing proximate determinants of fertility. Popul Dev Rev 1978;4:105-31.

Chaurasia AR, Gulati SC. India: The State of Population 2007. New Delhi, India: Government of India, National Population Commission and Oxford University Press; 2008.

Chaurasia AR, Singh R. Forty Years of Planned Family Planning Efforts in India. In: Proceedings of the 2013 IUSSP International Population Conference, Bussan, Republic of Korea, 2013. Bussan, Republic of Korea: The 2013 IUSSP International Population Conference; 2013.

International Institute for Population Sciences, District Level Household and Facility Survey (DLHS-3), 2007-08, IIPS, Mumbai, India; 2010.

United Nations. Update for the MDG Database: Contraceptive Prevalence. New York, USA: Department of Economic and Social Affairs, Population Division; 2012.

United Nations Population Division (UNPD), Department of Economic and Social Aff airs. Guidelines on Reproductive Health; 1995.

United Nations, General Assembly. Transforming our World: The 2030 Agenda for Sustainable Development, No. A/RES/70/1. Oct 21, 2015.

Kavanaugh ML, Anderson RM. Contraception and Beyond: The Health Benefits of Services Provided at Family Planning Centers. New York: Guttmacher Institute;

Bertrand G. Simple points, topological numbers and geodesic neighborhoods in cubic grids. Pattern Recognit Lett ;15:1003-11.

Steele F, Diamond I. Contraceptive switching in Bangladesh. Stud Fam Plann ;30:315-28.

Sullivan TM, Bertrand JT, Rice J, Shelton JD. Skewed contraceptive method mix: Why it happens, why it matters. J Biosoc Sci ;38:501-21.

Cleland J, Ali MM. Reproductive consequences of contraceptive failure in 19 developing countries. Obstetr Gynecol ;104:314-20.

Blanc AK, Curtis SL, Croft TN. Monitoring contraceptive continuation: Links to fertility outcomes and quality of care. Stud Fam Plann ;33:127-40.

Vaughan B, Trussell J, Kost K, Singh S, Jones R. Discontinuation and resumption of contraceptive use: Results from the 2002 national survey of family growth. Contraception ;28:271-83.

Ali M, Cleland J. Contraceptive discontinuation in six developing countries: A cause-specific analysis. Int Fam Plann Perspect ;21:92-7.

Blanc AK, Curtis SL, Croft TN. Monitoring contraceptive continuation: Links to fertility outcomes and quality of care. Stud Fam Plann 2002;33:127-40.

Bradley SE, Schwandt H, Khan S. Levels, Trends, and Reasons for Contraceptive Discontinuation (DHS Analytical Studies No. 20). Calverton, MD: Macro International;

Steele F, Curtis S. Appropriate methods for analyzing the effect of method choice on contraceptive discontinuation. Demography ;40:1 22.

Mitra SN, Al-Sabir A. Contraceptive use Dynamics in Bangladesh (DHS Working Paper No. 21). Calverton, MD: Macro International;

Singh KK., Roy TK, Singh BP. Contraceptive discontinuation and switching patterns in Bangladesh. Genus ;66:63-88.

Jejeebhoy SJ. Women’s status and fertility: Successive cross-sectional evidence from Tamil Nadu, India, 1970-80. Stud Fam Plann ;22:217 30.

Trussell J. Contraceptive failure in the United States. Contraception ;83:397-404.

Cotten N, Stanback J, Maidouka H, Taylor-Thomas JT, Turk T. Early discontinuation of contraceptive use in Niger and the Gambia. Int Fam Plann Perspect ;18:145-9.

Mohanty SK, Fink G, Chauhan RK, Canning D. Distal determinants of fertility decline: Evidence from 640 Indian districts. Demogr Res ;34:373-406.

International Institute for Population Sciences. National Family and Health Survey, 2015–15 (State Fact Sheet). Ministry of Health and Family Welfare, Government of India; Available from: http://www.rchiips.org/nfhs/factsheet_NFHS-4.shtm.

Chaurasia AR. Contraceptive use in India: A data mining approach. Int J Popul Res :Article ID: 821436, 11 Pages.

Bhat PM, Zavier AF. Role of religion in fertility decline: The case of Indian Muslims. Econ Polit Wkly ;40:385-402.

Guilmoto CZ, Rajan SI. Spatial patterns of fertility transition in Indian districts. Popul Dev Rev ;27:713-38.

Mohanty SK, Ram F. Spatial pattern of poverty reduction and fertility transition in India. Popul Rev ;50:62-78.

Ram U, Dwivedi LK, Goswami B. Understanding contraception use among Muslims of India, Pakistan and Bangladesh. J Popul Soc Stud ;15:101-30.

Zhang F, Tsui AO, Suchindran CM. The Determinants of Contraceptive Discontinuation in Northern India: A Multilevel Analysis of Calendar Data. Chapel Hill: MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill;

Mohamed GA, Ibrahim SR, Al Haidari RA. A review on natural contraceptive agents. Am J PharmTech Res 2014;4:124-58.

Unny R, Chauhan AK, Joshi YC, Dobhal MP, Gupta RS. A review on potentiality of medicinal plants as the source of new contraceptive principles. Phytomedicine 2003;10:233-60.

Sathiyaraj K, Sivaraj A, Thirumalai T, Senthilkumar B. Ethnobotanical study of antifertility medicinal plants used by the local people in Kathiyavadi village, Vellore District, Tamil Nadu, India. Asian Pac J Trop Biomed 2012;2:S1285-8.

Priya G, Saravanan K, Renuka C. Medicinal plants with potential antifertility activity-A review of sixteen years of herbal medicine research (1994-2010). Int J PharmTech Res 2012;4:481-94.

Shah GM, Khan MA, Ahmad M, Zafar M, Khan AA. Observations on antifertility and abortifacient herbal drugs. Afr J Biotechnol 2009;8:1959-64.

Kaur R, Sharma A, Kumar R, Kharb R. Rising trends towards herbal contraceptives. J Natl Prod Plant Resour 2011;1:5-12.

Ahmad S, Jamal Y, Mannan A: Review of some medicinal plants with anti-fertility activities. Unani Res 2011;1:24-8.

Qureshi AA, Sanghai DB, Padgilwar SS. Herbal options for contraception: A review. Pharmacog Mag 2006;2:204-15.

Kaur R, Sharma A, Kumar R, Kharb R. Rising trends towards herbal contraceptives. J Natl Prod Plant Resour 2011;1:5-12.

Umadevi M, Kumar PS, Bhowmik D, Duraivel S. Medical plants with potential antifertility activity. J Med Plants Stud 2013;1:26-33.

Shukla A, Jamwal R, Bala K. Adverse effect of combined oral contraceptive pills. Asian J Pharm Clin Res 2017;10:17-21.

Parrota AJ. Healing Plants of Peninsular India. New York: CABI Publishing; 2001. p. 475-8.

Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: CSIR; 1950. p. 133.

Kholkute SD. Effect of Hibiscus rosa-sinensis on spermatogenesis and accessory reproductive organs in rats. Planta Med 1977;31:127-35.

Parmar NS, Ghosh MN. Antiinflammatory activity of gossypin, a bioflavonoid isolated from Hibiscus viti-folius. Linn. Indian J Pharmacog 1978;10:277-29.

Gangrade H, Mishra SH, Kaushal R. Antimicrobial activity of oil and unsaponifiable matter of red roselle. Indian Drugs 1979;16:147-8.

Jain R, Arora R, Jain SC. Chemical constituents and bioactivity studies of Hibiscus micranthus. Linn. Indian J Pharm Sci 1997;91-3.

Faraji MH, Tarkhani AH. The effect of sour tea (Hibiscus sabdariffa.) on essential hypertension. J Ethnopharmacol 1999;65:231-6.

Lin WL, Hsieh YJ, Chou FP, Wang CJ, Cheng MT, Tseng TH. Hibiscus. protocatechuic acid inhibits lipo-polysaccharide induce rat hepatic damage. Arch Toxicol 2003;77:42-7.

Sachdewa A, Khemani LD. Effect of Hibiscus rosa-sinensis. Linn, ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats. J Ethnopharmacol 2003;89:61-6.

Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Hibiscus rosa-sinensis Linn–‘‘Rudrapuspa’’: A review. J Pharm Res 2009;2:1168-73.

Srivastava DN, Bhatt SK, Udupa KN. Gas chromatographic identification of fatty acids, fatty alcohols, and hydrocarbons of Hibiscus rosa-sinensis leaves. J Am Oil Chem Soc 1976;53:607-8.

Agarwal S, Prakash R. Phytochemical analysis of the benzene extract of Hibiscus rosa-sinensis. Ultra Chem 2013;9:178-9.

Murthy DR, Reddy CM, Patil SB. Effect of benzene extract of Hibiscus rosa-sinensis on the estrous cycle and ovarian activity in albino mice. Biol Pharm Bull 1997;20:756-8.

Kholkute SD, Udupa KN. Antifertility properties of Hibiscus rosa-sinensis. J Res Indian Med 1974;9:105.

Batta SK, Santhakumari G. The antifertility effect of Ocimum sanctum and Hibiscus cosa sinensis. Indian J Med Res 1970;59:777-81.

Gupta ML, Gupta TK, Bhargava KP. A Study of antifertility effects of some indigeneous drugs. J Res Ind Med 1971;6:46-51.

Prakash AO. Effect of Hibiscus rosa-sinensis Linn. extracts on corpora lutea of cyclic guinea pigs. Sci Cult 1980;46:330-1.

Singh SP, Singh N, Kohli RP. Antifertility Studies of some indigenous plants. Indian J Pharmacol 1978;10:88.

Singh MS, Lal SB. Cytostatic and cytotoxic effects of flower extract of Hibiscus rosa-sinenses on spermatogenically and and rogenically active testes of a non-scrotal bat; Rhinopoma kinneari wroughton. Indian J Exp Bio 1980;18:1405.

Tewari PV. Preliminary clinical trial on flowers of Hibiscus rosa-sinensis as an oral contraceptive agent. J Res Indian Med 1974;9:105.

Kholkute SD, Chatterjee S, Udupa KN. Effect of Hibiscus rosa-sinensis Linn. on oestrous cycle and reproductive organs in rats. Indian J Exp Biol 1976;14:703.

Vasudeva N, Sharma SK. Post-coital antifertility activity of Hibiscus rosa-sinensis Linn. roots. Evid Based Complementary Altern Med 2008;5:91-4.

Kholkute SD. Effect of Hibiscus rosa-sinensis on spermatogenesis and accessory reproductive organs in rats. Planta Med 1977;31:127-35.

Pakrashi A, Bhattacharya K, Kabir SN, Pal AK. Flowers of Hibiscus rosa-sinensis, a potential source of contragestative agent. III: Interceptive effect of benzene extract in mouse. Contraception 2005;71:227-30.

Nivsarkar M, Patel M, Padh H, Bapu C, Shrivastava N. Blastocyst implantation failure in mice due to nonreceptive endometriumâ€: Endometrial alterations by Hibiscus rosa-sinensis leaf extract. Contraception 2005;71:227-30.

Nivsarkar M, Patel M, Padh H, Bapu C, Shrivastava N. Blastocyst implantation failure in mice due to nonreceptive endometriumâ€: Endometrial alterations by Hibiscus rosa-sinensis leaf extract. Contraception 2005;71:227-30.

Ross IA. Constituents, Traditional and Modern Medicinal Uses. Vol. 1. New York: CBS Publishers; 2001. p. 257-60.

Sharma PC, Yelne MB, Dennis TJ, Joshi A, Billore KV. Database on Medicinal Plants used in Ayurveda. New Delhi: Central Council for Research in Ayurveda & Siddha; 2000.

Bhakuni OS, Dhar ML, Dhar MM, Dhavan BN, Mehrotra BN. Screening of Indian plants for biological activity, Part II. Indian J Exp Biol 1969;7:250-62.

Devi P, Kumar P, Dhamija I. Antifertility activity of medicinal plants on male and female reproduction. Int J Pharm Sci Res 2015;6:988.

Pekamwar SS, Kalyankar TM, Jadhav AC. Hibiscus rosa-sinensis: A review on ornamental plant. World J Pharm Pharm Sci 2013;2:4719-27.

Murthy DR, Reddy CM, Patil SB. Effect of benzene extract of Hibiscus rosa-sinensis on the estrous cycle and ovarian activity in albino mice. Biol Pharm Bull 1997;20:756-8.

Jain CM, Bharathi K. Critical review of scientific validity of indigenous female contraceptive drugs described in Ayurvedic literature. Indian J Trad Knowl 2011;10:678-81.

Jana TK, Das S, Ray A, Mandal D, Jana SG, Bhattacharya J. Study of the effects of Hibiscus-rosa-sinensis flower extract on the spermatogenesis of male albino rats. J Physiol Pharmacol Adv 2013;3:167-71.

Kholkute SD. Effect of Hibiscus rosa-sinensis on spermatogenesis and accessory reproductive organs in rats. Planta Med 1977;31:127-35.

Pokale S, Kulkarni K. Evaluation of antifertility potential of aqueous extract of Sida cardifolia linn. Plant in swiss albino mice. Int J Pharm Pharm Sci 2012;4:128-31.

Nayaka HB, Londonkar RL, Umesh MK. Evaluation of Portulaca oleracea L. For anti-fertility effect in female albino rats. Int J Pharm Pharm Sci 2014;6:86-9.

Anand AK, Prasad V, Alam M. Herbal or modern methods of contraception! Choice is yours. Int J Reprod Contracept Obstet Gynecol 2015;4:947-53.

Published

07-11-2018

How to Cite

Baghel Chauhan, S., and T. Naved. “HERBAL CONTRACEPTIVES: EVALUATION OF ANTIFERTILITY POTENTIAL OF HIBISCUS ROSA‑SINENSIS (LINN.)”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 11, Nov. 2018, pp. 36-41, doi:10.22159/ajpcr.2018.v11i11.20531.

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Section

Review Article(s)