EXPLOITATION OF HUB PROTEINS AS DRUG TARGETS FOR MYCOBACTERIUM TUBERCULOSIS H37RV

ASRA’A A  ABDUL-JALIL

doi:10.22159/ajpcr.2017.v10i11.20662

Authors

ASRA’A A ABDUL-JALIL University of Anbar Collage of Science .

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i11.20662

Keywords:

Mycobacterium tuberculosis, Candidate drug targets, Interactome, Low-complexity regions

Abstract

Objective: Mycobacterium tuberculosis (TB), a causative agent of TB, increased the resistance to most drugs in use and coinfection with HIV. It needs the new drug(s), the latter should be special candidate targets.

Methods: Hub proteins were studied (Rv2198c, Rv2507, and Rv3763) which had very high connected partners. These were modeled to be used for screening chemical databases.

Results: The proteins were found to be with increased low-complexity regions especially at the amino ends, they exhibited primary level (layers) of interactions and involved in secondary and more levels of interactions.

Conclusions: The proteins with high interacting partners would be good targets as their disruption will disturb the cellular functions. The chosen targets (Rv2198c, Rv2507, and Rv3763) have very high interactions at a different level (layers), they were modeled to be used in survey of chemical databases.

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