ANTICANCER ACTIVITY OF ARGEMONE MEXICANA L (FLOWERS) AGAINST HUMAN LIVER CANCER (HEPG2) CELL LINE

Prabhakaran D; Senthamilselvi Mm; Rajeshkanna A

doi:10.22159/ajpcr.2017.v10i10.20744

Authors

Prabhakaran D Department of Chemistry Periyar E.V.R. College (Autonomous), Trichy, Tamil Nadu, India
Senthamilselvi Mm Department of Higher Education, Joint Director of Collegiate Education, Tiruchirappalli, Tamil Nadu, India.
Rajeshkanna A Department of Chemistry, Periyar E. V. R. College (Autonomous), Tiruchirappalli, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i10.20744

Keywords:

Argemone mexicana L, Anticancer activity, MTT assay, HepG2, Cytotoxicity

Abstract

Â

Â Objective: To explore the anticancer activity of the flowers of Argemone mexicana L. against the human hepatoma cell line (HepG2).

Methods: In vitro anticancer activity was carried out to screen cytotoxicity effectiveness of the solid obtained from ethyl acetate fraction of A. mexicana L. flower extract at different concentrations against the HepG2 cell line. The MTT (methylthiazolyl diphenyl- tetrazolium bromide) assay for cell viability and markers is expected to confirm the cytotoxicity.

Result: Ethyl acetate fraction from the flower extract of A. mexicana L. was tested for its anticancer activity against HepG2 cell lines (liver cancer) at various concentrations by MTT assay. It was confirmed that the IC50 value of this sample was 72Â±1.7 Î¼g/ml against liver cancer HepG2 cell line.

Conclusions: A. mexicana L. is a potential plant with anticancer activity. The isolation of the pure compounds and determination of the structure of individual compounds will be further performed.

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