A REVIEW ON MEDICINAL PROPERTIES OF CENTELLA ASIATICA
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i10.20760Keywords:
Centella asiatica, Pharmacology, Chemical constituents, Therapeutic usageAbstract
Plant-based drug discovery has drawn the attention of researchers, especially the one used as traditional medicines. Centella asiatica is traditional Ayurveda medicine widely used in India and across Asia for treating a variety of diseases. The aerial parts and roots are used for medicinal purpose, and its chemical constituents have wide therapeutic applications in areas of antimicrobial, anti-inflammatory, anticancer, neuroprotective, antioxidant, and wound healing activities. Many of its uses have been proven scientifically, and bioactive ingredients have been validated. In this review, we have done a critical evaluation of available literature looking for the pharmacological importance of C. asiatica. Further studies will be helpful to discover more bioactive compounds their exact mode of actions.
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References
Shanghai PR. Jiangsu new medical college. Dictionary of Chinese Materia Medica. China: Shanghai Scientific and Technical Publishing House; 1977. p. 1874.
Yu QL, Duan HQ, Takaishi Y, Gao WY. A novel triterpene from Centella asiatica. Molecules 2006;11(9):661-5.
Jamil SS, Nizami Q, Salam M. Centella asiatica (Linn.) Urban-a review. Nat Prod Radiance 2007;6(2):158-70.
Diwan PV, Karwande I, Singh AK. Anti-anxiety profile of manduk parni (Centella asiatica) in animals. Fitoterapia 1991;62:253-7.
Wagner H, Nörr H, Winterhoff H. Plant adaptogens. Phytomedicine 1994;1(1):63-76.
Mishra LC, editor. Scientific Basis for Ayurvedic Therapies. New York: CRC Press; 2003.
Periyasamy A, Mahalingam K. Phytochemical screening and antimicrobial activity from five Indian medicinal plants against human pathogens. Middle East J Sci Res 2010;5(6):477-82.
Roy DC, Barman SK, Shaik MM. Current updates on Centella asiatica: Phytochemistry, pharmacology and traditional uses. Med Plant Res 2013;3(4):70-7.
James JT, Dubery IA. Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. Molecules 2009;14(10):3922-41.
Francis SC, Thomas MT. Essential oil profiling of Centella asiatica (L.) Urb-a medicinally important herb. South Indian J Biol Sci 2016;2(1):169-73.
Siddiqui BS, Aslam H, Ali ST, Khan S, Begum S. Chemical constituents of Centella asiatica. J Asian Nat Prod Res 2007;9(3-5):407-14.
Inamdar PK, Yeole RD, Ghogare AB, De Souza NJ. Determination of biologically active constituents in Centella asiatica. J Chromatogr A 1996;742(1-2):127-30.
Randriamampionona D, Diallo B, Rakotoniriana F, Rabemanantso C, Cheuk K, Corbisier AM, et al. Comparative analysis of active constituents in Centella asiatica samples from Madagascar: Application for ex situ conservation and clonal propagation. Fitoterapia 2007;78(7-8):482-9.
Yu QL, Duan HQ, Gao WY, Takaishi Y. A new triterpene and a saponin from Centella asiatica. Chin Chem Lett 2007;18(1):62-4.
Wang L, Xu J, Zhao C, Zhao L, Feng B. Antiproliferative, cell-cycle dysregulation effects of novel asiatic acid derivatives on human non-small cell lung cancer cells. Chem Pharm Bull (Tokyo) 2013;61(10):1015-23.
Pittella F, Dutra RC, Junior DD, Lopes MT, Barbosa NR. Antioxidant and cytotoxic activities of Centella asiatica (L) Urb. Int J Mol Sci 2009;10(10):3713-21.
Babykutty S, Padikkala J, Sathiadevan P, Vijayakurup V, Azis T, Srinivas P, et al. Apoptosis induction of Centella asiatica on human breast cancer cells. Afr J Tradit Complement Altern Med 2009;6(1):9-16.
Hussin F, Eshkoor SA, Rahmat A, Othman F, Akim A. The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC). BMC Complement Altern Med 2014;14:32.
Wu T, Geng J, Guo W, Gao J, Zhu X. Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria. Acta Pharm Sin B 2017;7(1):65-72.
Park BC, Bosire KO, Lee ES, Lee YS, Kim JA. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett 2005;218(1):81-90.
Zhang J, Ai L, Lv T, Jiang X, Liu F. Asiatic acid, a triterpene, inhibits cell proliferation through regulating the expression of focal adhesion kinase in multiple myeloma cells. Oncol Lett 2013;6(6):1762-6.
Kwon KJ, Bae S, Kim K, An IS, Ahn KJ, An S, et al. Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma. Mol Med Rep 2014;10(1):503-7.
Babu TD, Kuttan G, Padikkala J. Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. J Ethnopharmacol 1995;48(1):53-7.
Ren L, Cao QX, Zhai FR, Yang SQ, Zhang HX. Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling. Pharm Biol 2016;54(11):2377-82.
Kim KB, Kim K, Bae S, Choi Y, Cha HJ, Kim SY, et al. MicroRNA-1290 promotes asiatic acid-induced apoptosis by decreasing BCL2 protein level in A549 non-small cell lung carcinoma cells. Oncol Rep 2014;32(3):1029-36.
Zaidan MR, Noor Rain A, Badrul AR, Adlin A, Norazah A, Zakiah I. In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method. Trop Biomed 2005;22(2):165-70.
Oyedeji OA, Afolayan AJ. Chemical composition and antibacterial activity of the essential oil of Centella asiatica. Growing in South Africa. Pharma Biol 2005;43(3):249-52.
Pitinidhipat N. Antibacterial activity of Chrysanthemum indicum, Centella asiatica and Andrographis paniculata against Bacillus cereus and Listeria monocytogenes under osmotic stress. AUJT 2015;15(4):239-45.
Sekar T, Ayyanar M, Pillai YJ. Phytochemical screening and antibacterial activity of leaf and callus extracts of Centella asiatica. Bangladesh J Pharmacol 2011;6(1):55-60.
Dash BK, Faruquee HM, Biswas SK, Alam MK, Sisir SM, Prodhan UK. Antibacterial and antifungal activities of several extracts of Centella asiatica L. against some human pathogenic microbes. Life Sci Med Res 2011;2011:1-5.
Dhiman R, Aggarwal N, Aneja KR, Kaur M. In vitro antimicrobial activity of spices and medicinal herbs against selected microbes associated with juices. Int J Microbiol 2016;2016:9015802.
Idris NA, Nadzir MM. Antimicrobial activity of Centella asiatica on Aspergillus niger and Bacillus subtilis. Chem Eng Trans 2017;56:1381-6.
Sultan RA, Mahmood SB, Azhar I, Ahmed SW, Mahmood ZA. Biological activities assessment of Centella asiatica (Linn.). J Herbs Spices Med Plants 2014;20(3):319-27.
Sultana N, Saify ZS. Naturally occurring and synthetic agents as potential anti-inflammatory and immunomodulants. Antiinflamm Antiallergy Agents Med Chem 2012;11(1):3-19.
Prakash V. Terpenoids as source of anti-inflammatory compounds. Asian J Pharm Clin Res 2017;10(3):68-76.
Chippada SC, Volluri SS, Bammidi SR, Vangalapati M. In vitro anti-inflammatory activity of methanolic extract of Centella asiatica by HRBC membrane stabilisation. Rasayan J Chem 2011;4(2):457-60.
Somchit MN, Sulaiman MR, Zuraini A, Samsuddin L, Somchit N, Israf DA, et al. Antinociceptive and antiinflammatory effects of Centella asiatica. Indian J Pharmacol 2004;36(6):377.
George M, Joseph L, Ramaswamy. Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts. Afr J Tradit Complement Altern Med 2009;6(4):554-9.
Huang SS, Chiu CS, Chen HJ, Hou WC, Sheu MJ, Lin Y, et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic acid in mice. Evid Based Complement Alternat Med 2011;2011:895857.
Saha S, Guria T, Singha T, Maity TK. Evaluation of analgesic and anti-inflammatory activity of chloroform and methanol extracts of Centella asiatica Linn. ISRN Pharmacol 2013;2013:789613.
Orhan IE. Centella asiatica (L.) Urban: From traditional medicine to modern medicine with neuroprotective potential. Evid Based Complement Altern Med 2012;2012:946259.
Defillipo PP, Raposo AH, Fedoce AG, Ferreira AS, Polonini HC, Gattaz WF, et al. Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract. Nat Prod Commun 2012;7(7):841-3.
Nasir MN, Habsah M, Zamzuri I, Rammes G, Hasnan J, Abdullah J. Effects of asiatic acid on passive and active avoidance task in male Spraque - Dawley rats. J Ethnopharmacol 2011;134(2):203-9.
Thomas TN, Thomas PM. Patent Application No. 14/848,372. U.S; 2015.
Prakash A, Kumar A. Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: Possible relevance to its anti-oxidant and anti-apoptosis mechanism. Neurol Sci 2013;34(8):1403-9.
Gopi M, Arambakkam Janardhanam V. Asiaticoside: Attenuation of rotenone induced oxidative burden in a rat model of hemiparkinsonism by maintaining the phosphoinositide-mediated synaptic integrity. Pharmacol Biochem Behav 2017;155:1-15.
Orhan IE, Atasu E, Senol FS, Ozturk N, Demirci B, Das K, et al. Comparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization. Ind Crops Prod 2013;47:316-322.
Hussin M, Abdul-Hamid A, Mohamad S, Saari N, Ismail M, Bejo MH. Protective effect of Centella asiatica extract and powder on oxidative stress in rats. Food Chem 2007;100(2):535-41.
Raza SA, Adnan A, Qureshi F. Comparison of antioxidant activity of essential oil of Centella asiatica and Butylatedhydroxyanisole in sunflower oil at ambient conditions. Biharean Biol 2009;3(1):71-5.
Chandrika UG, Kumara PA. Gotu Kola (Centella asiatica): Nutritional properties and plausible health benefits. Adv Food Nutr Res 2015;76:125-57.
Jayashree G, Kurup Muraleedhara GK, Sudarslal S, Jacob VB. Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice. Fitoterapia 2003;74(5):431-4.
Anand T, Mahadeva N, Phani KG, Farhath K. Antioxidant and DNA damage preventive properties of Centella asiatica (L) Urb. Pharm J 2010;2(17):53-8.
Suguna L, Sivakumar P, Chandrakasan G. Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Exp Biol 1996;34(12):1208-11.
Shetty BS, Udupa SL, Udupa AL, Somayaji SN. Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar Albino rats. Int J Low Extrem Wounds 2006;5(3):137-43.
Somboonwong J, Kankaisre M, Tantisira B, Tantisira MH. Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: An experimental animal study. BMC Complement Altern Med 2012;12:103.
Cheng CL, Koo MW. Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Life Sci 2000;67(21):2647-53.
Yao CH, Yeh JY, Chen YS, Li MH, Huang CH. Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model. J Tissue Eng Regen Med 2017;11(3):905-15.
Bhavna D, Jyoti K. Centella asiatica: The elixir of life. Int J Res Ayurveda Pharm 2011;2(2):431-8.
Chen Y, Han T, Qin L, Rui Y, Zheng H. Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice. Zhong Yao Cai 2003;26(12):870-3.
Chen Y, Han T, Rui Y, Yin M, Qin L, Zheng H. Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain. Zhon Yao Cai 2005;28(6):492-6.
Kalshetty P, Aswar U, Bodhankar S, Sinnathambi A, Mohan V, Thakurdesai P. Antidepressant effects of standardized extract of Centella asiatica L in olfactory bulbectomy model. Biomed Aging Pathol 2012;2(2):48-53.
Ceremuga TE, Valdivieso D, Kenner C, Lucia A, Lathrop K, Stailey O, Taylor A. Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat. AANA J 2015;83(2):91-8.
Rahman MM, Sayeed MS, Haque MA, Hassan MM, Islam SA. Phytochemical screening, antioxidant, anti-Alzheimer and anti-diabetic activities of Centella asiatica. J Nat Prod Plant Resour 2012;2(4):504-11.
Gayathri V, Lekshmi P, Padmanabhan RN. Anti-diabetes activity of ethanol extract of Centella asiatica (L.) urban (whole plant) in Streptozotocin-induced diabetic rats, isolation of an active fraction and toxicity evaluation of the extract. Int J Med Aromat Plants 2011;1(3):278-6.
Supkamonseni N, Thinkratok A, Meksuriyen D, Srisawat R. Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo. Indian J Exp Biol 2014;52(10):965-71.
Haque S, Naznine T, Ali M, Azad TT, Morshed T, Afsana NA, et al. Antihyperglycemic activities of leaves of Brassica oleracea, Centella asiatica and Zizyphus mauritiana: Evaluation through oral glucose tolerance tests. Adv Nat Appl Sci 2013;7(5):519-26.
Rahman S, Jamal MM, Parvin A, Mahfuz-Al-Mamun M, Islam MR. Antidiabetic activity of Centella asiatica (L.) urbana in alloxan induced Type 1 diabetic model rats. J Biosci 2012;19:23-7.
Kabir AU, Samad MB, D’Costa NM, Akhter F, Ahmed A, Hannan JM. Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding. BMC Complement Altern Med 2014;14:31. 69. Maulidiani, Abas F, Khatib A, Perumal V, Suppaiah V, Ismail A, et al. Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract. J Ethnopharmacol 2016;180:60-9.
Wang X, Lu Q, Yu DS, Chen YP, Shang J, Zhang LY, et al. Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous Type 2 diabetic animal model. Chin J Nat Med 2015;13(7):529-34.
Liu J, He T, Lu Q, Shang J, Sun H, Zhang L. Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. Diabetes Metab Res Rev 2010;26(6):448-54.
Chaisawang P, Sirichoat A, Chaijaroonkhanarak W, Pannangrong W, Sripanidkulchai B, Wigmore P, et al. Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy. PLoS One 2017;12(7):e0180650.
Gray NE, Zweig JA, Murchison C, Caruso M, Matthews DG, Kawamoto C, et al. Centella asiatica attenuates Aß-induced neurodegenerative spine loss and dendritic simplification. Neurosci Lett 2017;646:24-9.
Farhana KM, Malueka RG, Wibowo S, Gofir A. Effectiveness of Gotu Kola extract 750?mg and 1000?mg compared with folic acid 3?mg in improving vascular cognitive impairment after stroke. Evid Based Complement Alternat Med 2016;2016:2795915.
Umka Welbat J, Sirichoat A, Chaijaroonkhanarak W, Prachaney P, Pannangrong W, Pakdeechote P, et al. Asiatic acid prevents the deleterious effects of valproic acid on cognition and hippocampal cell proliferation and survival. Nutrients 2016;8(5). pii: E303.
Gray NE, Harris CJ, Quinn JF, Soumyanath A. Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice. J Ethnopharmacol 2016;180:78-6.
Gray NE, Sampath H, Zweig JA, Quinn JF, Soumyanath A. Centella asiatica attenuates amyloid-ß-induced oxidative stress and mitochondrial dysfunction. J Alzheimers Dis 2015;45(3):933-46.
Sirichoat A, Chaijaroonkhanarak W, Prachaney P, Pannangrong W, Leksomboon R, Chaichun A, et al. Effects of asiatic Acid on spatial working memory and cell proliferation in the adult rat hippocampus. Nutrients 2015;7:8413-23.
Lin X, Huang R, Zhang S, Wei L, Zhuo L, Wu X, et al. Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice. Fitoterapia 2013;87(10):69-77.
Xu MF, Xiong YY, Liu JK, Qian JJ, Zhu L, Gao J. Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells. Acta Pharmacol Sin 2012;33(5):578-7.
Kumar A, Prakash A, Dogra S. Centella asiatica attenuates D-galactose-induced cognitive impairment, oxidative and mitochondrial dysfunction in mice. Int J Alzheimers Dis 2011;2011:347569.
Kumar A, Dogra S, Prakash A. Neuroprotective effects of Centella asiatica against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress. Int J Alzheimers Dis 2009;2009. pii: 972178.
Ponnusamy K, Mohan M, Nagaraja HS. Protective antioxidant effect of Centella asiatica bioflavonoids on lead acetate induced neurotoxicity. Med J Malaysia 2008;63 Suppl A:102.
Xu Y, Cao Z, Khan I, Luo Y. Gotu Kola (Centella asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide. J Alzheimers Dis 2008;13(3):341-9.
Wattanathorn J, Mator L, Muchimapura S, Tongun T, Pasuriwong O, Piyawatkul N, et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol 2008;116(2):325-2.
Veerendra Kumar MH, Gupta YK. Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer’s disease in rats. Clin Exp Pharmacol Physiol 2003;30(5-6):336-42.
Oyenihi AB, Chegou NN, Oguntibeju OO, Masola B. Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in Type 2 diabetic rats. Pharm Biol 2017;55(1):1671-8.
Choi MJ, Zheng HM, Kim JM, Lee KW, Park YH, Lee DH. Protective effects of Centella asiatica leaf extract on dimethylnitrosamine-induced liver injury in rats. Mol Med Rep 2016;14(5):4521-8.
Ghosh K, Indra N, Jagadeesan G. The ameliorating effect of Centella asiatica ethanolic extract on albino rats treated with isoniazid. J Basic Clin Physiol Pharmacol 2017;28(1):67-7.
Duggina P, Kalla CM, Varikasuvu SR, Bukke S, Tartte V. Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: Its possible mechanisms of action. J Physiol Biochem 2015;71(3):435-4.
Antony B, Santhakumari G, Merina B, Sheeba V, Mukkadan J. Hepatoprotective effect of Centella asiatica (L) in carbon tetrachloride-induced liver injury in rats. Indian J Pharm Sci 2006;68(6):772.
Jeong BS, Kim YC, Lee ES. Modification of C2, 3, 23, 28 functional groups on asiatic acid and evaluation of hepatoprotective effects. Bull Korean Chem Soc 2007;28(6):977-82.
Tang LX, He RH, Yang G, Tan JJ, Zhou L, Meng XM, et al. Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro. PLoS One 2012;7(2):e31350.
Rajalingam D, Varadharajan R, Palani S. Evaluation of hepatoprotective and antioxidant effect of Combretum albidum G. don against CCl4 induced hepatotoxicity in rats. Int J Pharm Pharm Sci 2016;8(9):218-23.
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