STUDY OF SERUM FERRITIN IN SMOKERS
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i1.21502Keywords:
Cigarette, Hematologic parameters, SmokersAbstract
 Objective: Cigarette smoking is a major global public health problem and increases in the prevalence of tobacco smoking is the cause premature death worldwide. Serum ferritin an intracellular protein that can store and release iron is considered to be one of the important clinical biomarkers to evaluate iron status. This study explores the effect of cigarette smoking on serum ferritin level.
Methods: The study was carried out in 100 cigarette smokers and 100 nonsmokers.
Results: Subjects with smoking habits showed a significant increase in the serum ferritin levels compared to nonsmokers. Serum iron level, as well as total iron-binding capacity, showed significant increase compared with nonsmokers. Serum ferritin is found to correlate with serum iron.
Conclusion: This study supports the fact that cigarette smoking has adverse effect on serum ferritin and other hematologic parameters, and serum ferritin is one of the most reliable indicators of iron status.
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References
Nordenberg D, Yip R, Binkin NJ. The effect of cigarette smoking on hemoglobin levels and anemia screening. JAMA 1990;264:1556-9.
Al-Awadhi AM, AlFadhli SM, Mustafa NY, Sharma PN. Effects of cigarette smoking on hematological parameters and von Willebrand factor functional activity levels in asymptomatic male and female Arab smokers. Med Princ Pract 2008;17:149-53.
Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care 2004;27:2422-8.
Lapenna D, de Gioia S, Mezzetti A, Ciofani G, Consoli A, Marzio L, et al. Cigarette smoke, ferritin, and lipid peroxidation. Am J Respir Crit Care Med 1995;151:431-5.
Cook JD, Lipschitz DA, Miles LE, Finch CA. Serum ferritin as a measure of iron states in normal subjects. MJ Clin Nutr 1974;271:681-7.
Stone RE, Nankap M, Ndjebayi AO, Erhardt JG, Brown PH. Plasma ferritin and soluble transferring receptors concentration and body iron stores identify similar risk factors for iron deficiency but result in different estimates of the national prevalence of iron deficiency among women. J Nutr 2013;143:369-77.
Bataller R. Time to ban smoking in patients with chronic liver diseases. Hepatology 2006;44:1394-6.
Lee CH, Goag EK, Lee SH, Chung KS, Jung JY, Park MS, et al. Association of serum ferritin levels with smoking and lung function in the Korean adult population: Analysis of the fourth and fifth Korean national health and nutrition examination survey. Int J Chron Obstruct Pulmon Dis 2016;11:3001-6.
Shivashekar M, Ramachandran K, William E. Response of ferritin to oxidative stress in Rheumatoid arthritis. Asian J Pharm Clin Res 2014;7 Suppl 1:93-4.
Sharma P, Kumar P, Sharma R, Kishore K, Sharma G. Assessment of metabolic syndrome: Role of serum ferritin. Asian J Pharm Clin Res 2016;9:240-3.
Cabello-Verrugio C, Ruiz-Ortega M, Mosqueira M, Simon F. Oxidative stress in disease and aging: Mechanisms and therapies. Claudio cabello-verrugio,1,2 Marta ruiz-ortega,3 Matias mosqueira,4 and Felipe Simon. Int J Pharm Pharm Sci 2016;3:2.
Brownell A, Lowson S, Bronzovic M. Serum ferritin concentration in sickle cell crises. J Clin Pathol 1986;39:359-78.
Maithreyi R, Janani AV, Krishna R, Shwetha A, Edwin RR, Mohan SK. Erythrocyte lipid peroxidation and antioxidant in chronic alcoholics with alcoholic liver disease. Asian J Pharm Clin Res 2010;3:181-5.
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