Simple Bone Cyst Treated with Percutaneous Steroid Injection
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i5.21775Keywords:
Simple bone cyst, Steroid injection, Bone healingAbstract
 Objectives: Through this study, we want to explore the effectiveness of methylprednisolone injections to treat simple bone cyst (SBC).
Methods: We collected the data of all patients with SBC who were treated with percutaneous steroid injection (PSI). The study was conducted in Cipto Mangunkusumo Hospital and we used a computerized search of operative reports to identify all SBC patients who were treated by PSI 3 times between 2013 and 2016.
Results: A total of 10 patients were reported in these serial cases, 8 males and 2 females. The average age of these subjects is 7.8 years old. Musculoskeletal Tumor Society functional score determine good result after 3rd injection of steroid. Bone healing evaluation using Chang Criteria showed a good healing proccess.
Conclusion: Steroid injection therapy for SBC yielded a good functional result. It gets solid union relatively quickly, simple operation procedure, widely available, with less side effect. Therefore, this procedure could be a choice for treatment of SBCs patient. Further study needs to be conducted with more sample size.
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Ulici A, Balanescu R, Topor L, Barbu M. The modern treatment of the simple bone cysts. J Med Life 2012;5:469-73.
Sakamoto A, Matsuda S, Yoshida T, Iwamoto Y. Clinical outcome following surgical intervention for a solitary bone cyst: Emphasis on treatment by curettage and steroid injection. J Orthop Sci 2010;15:553- 9.
Komiya S, Kawabata R, Zenmyo M, Hashimoto S, Inoue A. Increased concentrations of nitrate and nitrite in the cyst fluid suggesting increased nitric oxide synthesis in solitary bone cysts. J Orthop Res 2000;18:281- 8.
Gerasimov AM, Toporova SM, Furtseva LN, Berezhnoy AP, Vilensky EV, Alekseeva RI. The role of lysosomes in the pathogenesis of unicameral bone cysts. Clin Orthop Relat Res 1991;266:53-63.
Shindell R, Huurman WW, Lippiello L, Connolly JF. Prostaglandin levels in unicameral bone cysts treated by intralesional steroid injection. J Pediatr Orthop 1989;9:516-9.
Komiya S, Tsuzuki K, Mangham DC, Sugiyama M, Inoue A. Oxygen scavengers in simple bone cysts. Clin Orthop Relat Res 1994;308:199- 206.
Mirra JM, Bernard GW, Bullough PG, Johnston W, Mink G. Cementum-like bone production in solitary bone cysts. (so-called cementoma†of long bones). Report of three cases. Electron microscopic observations supporting a synovial origin to the simple bone cyst. Clin Orthop Relat Res 1978;305:295-307.
Vayego SA, De Conti OJ, Varella-Garcia M. Complex cytogenetic rearrangement in a case of unicameral bone cyst. Cancer Genet Cytogenet 1996;86:46-9.
Flont P, Kolacinska-Flont M, Niedzielski K. Factors predictive of positive response to steroid therapy in simple bone cysts: An old trick that still works. Int Orthop 2013;37:1519-25.
Suei Y, Taguchi A, Nagasaki T, Tanimoto K. Radiographic findings and prognosis of simple bone cysts of the jaws. Dentomaxillofac Radiol 2010;39:65-71.
Scaglietti O, Marchetti PG, Bartolozzi P. The effects of methylprednisolone acetate in the treatment of bone cysts. Results of three years follow-up. J Bone Joint Surg (Br) 1979;61:200-4
Kadhim M, Thacker M, Kadhim A. Treatment of unicameral bone cyst: Systematic review and meta-analysis. J Child Orthop 2014;8:171-91.
Hagmann S, Eichhorn F, Moradi B, Gotterbarm T, Dreher T, Lehner B, et al. Mid-and long-term clinical results of surgical therapy in unicameral bone cysts. BMC Musculoskelet Disord 2011;12:281.
Mylle J, Burssens A, Fabry G. Simple bone cysts. Arch Orthop Trauma Surg 1992;111:297-300.
Baig R, Eady JL. Unicameral (simple) bone cysts. S Med J 2006;99:966 76.
Haidar SG, Culliford DJ, Gent ED, Clark NM. Distance from the growth plate and its relation to the outcome of unicameral bone cyst treatment. J Child Orthop 2011;5:151-6.
Kao ST, Scott DD. A Review of bone substitutes. Oral Maxillofac Surg Clin N Am 2007;19:513-21.
Yandow S. What is the best treatment for simple bone cysts. In: Wright JG, editor. Evidence-Based Orthopaedics. 2nd ed. Philadelphia, PA: Elsevier; 2009. p. 683-702.
Campanacci M, Capanna R, Picci P. Unicameral and aneurysmal bone cysts. Clin Orthop Relat Res 1986;204:25-36.
Hashemi-Nejad A, Cole WG. Incomplete healing of simple bone cysts after steroid injections. J Bone Joint Surg 1997;79-B:5.
Cho Hs, Oh JH, Kim Hs, Kang Hg, Lee SH. Unicameral bone cysts a comparison of injection of steroid and grafting with autologous bone marrow. J Bone Joint Surg Br 2007;89-B:222-6.
Pavone V, Caff G, Di Silvestri C, Avondo S, Sessa G. Steroid injections in the treatment of humeral unicameral bone cysts: Long-term follow-up and review of the literature. Eur J Orthop Surg Traumatol 2014;24:497- 503.
Chang C, Stanton R, Glutting J. Unicameral bone cyst treated by injection of bone marrow or methylprednisolone. J Bone Joint Surg 2002;84:407-12.
Oppenheim WL, Galleno H. Operative treatment versus steroid injection in the management of unicameral bone cysts. J Pediatr Orthop 1984;4:1-7.
Faisham W, Nawasz AH, Ezane AW, Zulmi W, Ibrahim W, Halim AR. Non-Operative treatment versus steroid injections in the management of unicameral bone cysts. Malays Orthop J 2011;5:2.
Shirai T, Tsuchiya H, Terauchi R, Tsuchida S, Mizoshiri N, Ikoma K. Treatment of a simple bone cyst using a cannulated hydroxyapatite pin. Medicine 2015;94:25.
Corrêa GM, Abreu VG, De Abreu Martins DA, Takahashi JA, Fontoura HD, Cara DC, et al. Anti-inflammatory and antimicrobial activities of steroids and triterpenes isolated from aerial parts of Justicia acuminatissima (Acanthaceae). Int J Pharm Pharm Sci 2014;6:75-81.
Pratik M. Formulation, development, and evaluation of ethosomal drug delivery for terbinafine hydrochloride. Int J Pharm Adv Pharm 2014;4:200-6.
Sivakumar NR. Steroids in root canal treatment. Int J Pharm Pharm Sci 2014;6:17-9.
Umamaheswari A, Bhuvaneswari K, Ramalingam S. Steroid-induced anaphylaxis. Asiann J Pharm Clin Res 2017;10:1-2.
Palanisamy S, Sg K, Kumaran A, Rajasekaran A. A study on assessment, monitoring and reporting of adverse drug reactions in indian hospital. Asiann J of Pharm Clin Res 2011;4:2-3.
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