ANTI-INFLAMMATORY PROPERTIES OF PAVETTA CRASSICAULIS BREMEK. LEAF AND FLOWER CRUDE EXTRACTS AND ITS PURE COMPOUNDS COLLECTED FROM WESTERN GHATS, KARNATAKA, INDIA

Authors

  • Ashwathanarayana R Department of PG Studies and Research in Applied Botany, Jnanasahyadri, Kuvempu University, Shimogga - 577 451, Karnataka, India.
  • Raja Naika Department of PG Studies and Research in Applied Botany, Jnanasahyadri, Kuvempu University, Shimogga - 577 451, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i9.21885

Keywords:

Pavetta crassicaulis Bremek, Western Ghats, Karnataka, Anti-inflammatory, 2-tert-butyl-4, 6-bis(3, 5-di-tert-butyl-4-hydroxybenzyl) phenol, 4H-pyran-4-one, 2, 3-dihydro-3, 5-dihydroxy-6-methyl-

Abstract

Objective: Pavetta crassicaulis Bremek. (F: Rubiaceae) plant extracts were subjected to anti-inflammatory experiment by using carrageenin-induced rat hind paw edema method.

Methods: Groups of 5 rats of both sexes (pregnant females excluded) were given a dose of the extract. After 1 h, 0.1 ml, 1% carrageenan suspension in 0.9% NaCl solution was injected into the subplantar tissue of the right hind paw. Paw volume was measured plethysmometrically at 0 h and 3 h after carrageenin injection.

Results: Anti-inflammatory experiments revealed that, the leaf and flower ethanolic extract of the P. crassicaulis Bremek. plant shown excellent anti-inflammatory and its extracted pure compounds, 2-tert-butyl-4,6-bis(3,5-di-tert-butyl-4-hydroxybenzyl)phenol and 4H-pyran-4-one,2,3-dihydro3,5- dihydroxy-6-methyl- is a pure compound isolated from the Pavetta crassicaulis flower extract. showed excellent anti-inflammatory activity compared with the standard.

Conclusion: P. crassicaulis Bremek. leaf and flower could be exploited as a valuable source of anti-inflammatory agent for the pharmaceutical industry.

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Author Biography

Ashwathanarayana R, Department of PG Studies and Research in Applied Botany, Jnanasahyadri, Kuvempu University, Shimogga - 577 451, Karnataka, India.

Research Student Department of PG studies and Reserach in Applied Botany

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Published

07-09-2018

How to Cite

R, A., and R. Naika. “ANTI-INFLAMMATORY PROPERTIES OF PAVETTA CRASSICAULIS BREMEK. LEAF AND FLOWER CRUDE EXTRACTS AND ITS PURE COMPOUNDS COLLECTED FROM WESTERN GHATS, KARNATAKA, INDIA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 9, Sept. 2018, pp. 72-90, doi:10.22159/ajpcr.2018.v11i9.21885.

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