DESIGN AND CHARACTERIZATION OF OROSLIPPERY BUOYANT TABLETS FOR RANITIDINE HYDROCHLORIDE

Nidhal K Maraie; Zeina D Salman; Nora Zawar Yousif

doi:10.22159/ajpcr.2018.v11i1.21982

Authors

Nidhal K Maraie Department of Pharmaceutics, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.
Zeina D Salman Department of Pharmaceutics, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.
Nora Zawar Yousif Department of Pharmaceutics, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i1.21982

Keywords:

Ranitidine hydrochloride, Oroslippery tablet, Gastro retentive, Buoyant, Kollicoat infrared, Xanthan gum

Abstract

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Â Objective: The goal behind of performing this study was to come out with an oroslippery buoyant ranitidine hydrochloride tablet to ease the swallowing process. Hence, the drug is released controllably in the stomach regardless of the effect on gastric emptying time.

Materials and Methods: The core of the buoyant containing 150 mg of the drug was compressed directly, and sodium bicarbonate was employed as an effervescent agent, besides, hydroxyl propyl methyl cellulose (HPMC) polymer was utilized in different grades in the formulation process. The prepared core was immersed in the coating dispersion, which was formulated using xanthan gum (slipping agent) and Kollicoat instant release (IR) (for film formation). According to the variables in the formulation process, floating properties varies along with the release profile of the drug; therefore, investigation of the effects of variables was conducted, including polymer type and concentration in the core part, and the effect of Kollicoat IR amount as well as the level of coating.

Results: According to this study, it was clearly obvious that T4 formulation, that consisted of HPMC K4M, after being dipped 2 times in dispersion of 0.3% xanthan gum and 14% Kollicoat IR, had provided an instant floating, moreover, the in vivo slipperiness was quite acceptable as well as the taste masking. Nevertheless, the percentage of drug release measured after 6 h was 90.15%.

Conclusion: The resultant formulas is quite promising to take the lead as new approach to easy swallowing tablets without need of water especially for patients with swallowing problems as well as it is floating tablet that can retain the drug in gastric cavity to be continuously released to ensure its maximum absorption and may improve its bioavailability.

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References

Dineshmohan S, Vanitha K, Ramesh A, Srikanth G, Akila S. Formulation and evaluation of salbutamol sulphate fast dissolving tablet. Int J Pharm Biosci 2010;1:105-8.

Pandey VP, Ruby JJ. Orodispersible tablets-a review. World J Pharm Pharm Sci 2014;3:129-35.

Maraie NK, Alhamadany AT, Mahdi ZH. Application of the new oroslippery technology in the preparation of enteric slippery coated tablet of naproxen. Int J Pharm Pharm Sci 2017;9:198-204.

Sweetman SS. Martindale: The Complete Drug Reference. 36th ed. London: Pharmaceutical Press; 2009. p. 381.

Emara LA, Abdou AR, El-asmawy AA, Mursi NM. Preparation and evaluation of metronidazole sustained release floating tablets. Int J Pharm Pharm Sci 2014;6:198-204.

Albadry AA, Ali WK, Alsaady FA. Formulation and evaluation of prochlorperazine maleate sustained release floating tablet. Int J Pharm Pharm Sci 2016;9:89-98.

Singh S, Prajapati K, Pathak AK, Mishra A. Formulation and evaluation of floating tablet of captopril. Int J Pharmtech Res 2011;3:333-41.

Gulum S, Koksel F, Serpil S, Arzu B, Venkatesh M. Effect of xanthan and guar gums on quality and staling of gluten free cakes baked in microwave-infra red combination oven. Int J Food Sci Technol 2010;45:87-93.

Jaiswal H. Oral strip technology: A review. Indian J Pharm Biol Res 2014;2:130-43.

Mahdi ZH, Maraie NK. New easily swallowed tablets with slippery coating for the antihypertensive drug valsartan. UK J Pharm Biosci 2015;3:9-19.

McCabe TT, Stagner RA, Sutton JE. Inventors; Burroughs Wellcome Co., Research Triangle Park, N.C. Flavored Film-Coated Tablet. United States Patent US 005098715A; 1992.

Yousif NZ, Mahmood SZ, Salman ZD. Solubility enhancement, formulation and evaluation of furosemide stomach specific mucoadhesive tablet. Sci Rev Res 2016;40:258-65.

Kalia A, Khurna S, Bedi N. Formulation and evaluation of mouth dissolving tablets of oxycarbazepine. Int J Pharm Pharm Sci 2009;1:12-23.

Ramesh KA, Shabaraya AR, Mohd A, Kamath KK. Formulation and evaluation of pulsatile drug delivery system containing indomethacin using natural polymers. Int Res J Pharm 2013;4:111-4.

Ingale RD, Thakare VM, Tekade BW, Patil VR. Development and evaluation of rantidine hydrochloride floating tablet. Int J Pharm Sci Res 2014;5:269-74.

Natarajan R, Kaveri N, Rajndran NN. Formulation and evaluation of aceclofenac gastro retentive retentive drug delivery system. Res J Pharm Biol Chem Sci 2011;2:765-71.

Kumar PD, Rathnam G, Prakash CR, Saravanan G, Karthick V, Selvam TP. Formulation and characterization of bilayer floating tablets of ranitidine. Rasayan J Chem 2010;3:368-74.

Mishra AN, Rana A. UV spectrophotometric determination of ranitidine hydrochlorided in pure and pharmaceutical formulation. J Chem Sci 2009;7:2208-10.

Hsia R, Misra T, Saranteas K, Bonasia P Jr, Huang CG. Inventors; Sunovion Pharmaceuticals Inc. Coated Tablets of 6-(5-Chloro-2-Pyridyl)-5-[(4-Methyl-1-Piperazinyl) carbonyloXy]-7-Oxo-6,7-Dihydro-5hpyrrolo[3,4-b]Pyrazine and Methods for Measuring Effectiveness of Coating, Patent Candidate CA 2750059 A1; 2010.

Singh I, Saini V. Formulation and optimization of floating matrix tablets of clarithromycin using simplex lattice design. Pak J Pharm Sci 2016;29:511-9.

Srilakshmi P, Koushik KN, Raju SD, Rao RN, Prasanna LJ, Deepthi B. Formulation and evaluation of gastro retentive floating tablets of an antipsychotic drug. Am J Pharmtech Res 2014;4:470-6.

Rahman M, Roy S, Das SC, Jha MK, Begum T, Ahsan Q, et al. Evaluation of various grades of hydroxypropyl methylcellulose matrix systems as oral sustained release drug delivery systems. J Pharm Sci Res 2011;3:930-8.

Nicole K, Owen IC. Swelling and erosion properties of hydroxypropyl-methylcellulose (hypromellose) matrices-influence of agitation rate and dissolution medium composition. Int J Pharm 2004;279:141-52.

Maraie NK, Mohsen M, Neama M, Zuwar N. Few factors affecting the buoyancy and release of theophylline anhydrous from hydrodynamically balanced delivery system. Indian J Sci Technol 2011;6:85-94.

Soniya C, Manojkumar P, Gorakhnath H, Audmbar M, Santosh J. Formulation and evaluation of floating tablets of nizatidine. Int J Res Ayurveda Pharm 2015;6:290-8.

Patel D, Shivakumar S. Formulation and evaluation of floating capsules of 3rd generation cephalosporin. Int J Pharmtech Res 2012;4:986-93.

Siepmann J, Seipmann F, Paeratakul O. Process formulation and factors affecting drug release from pellets coated with ethyl cellulose pseudolatex aquacoat. In: Felton LA, McGinity JW, editors. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. 3rd ed. USA: CBC Press, Taylor and Francis Group Publishing; 2008. p. 203-36.

Ishak RA. Buoyancy-generating agents for stomach-specific drug delivery: An overview with special emphasis on floating behavior. J Pharm Pharm Sci 2015;18:77-100.

Srivastava A. Recent technologies for the tast masking of bitter drugs. Int J Pharm Pharm Res 2012;3:578-86.

Balakrishnan A. Therapeutic uses of peppermint-a review. J Pharm Sci Res 2015;7:474-6.