SERUM LEPTIN AND ADIPOSITY INDICATORS IN INFERTILE FEMALES OF REPRODUCTIVE AGE GROUP

Arul Senghor; Meera Shivashekar; Vm Vinodhini

doi:10.22159/ajpcr.2018.v11i6.23569

Authors

Arul Senghor Department of Biochemistry, SRM Medical College Hospital & Research Centre, Kattankulathur, Kanchipuram, Tamil Nadu, India.
Meera Shivashekar Department of Biochemistry, SRM Medical College Hospital & Research Centre, Kattankulathur, Kanchipuram, Tamil Nadu, India.
Vm Vinodhini Department of Biochemistry, SRM Medical College Hospital & Research Centre, Kattankulathur, Kanchipuram, Tamil Nadu, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i6.23569

Keywords:

Infertility, Obesity, Leptin, Waist circumference, Waist to height ratio, Body adiposity index

Abstract

Objectives: This study was designed to evaluate the interrelationship of adiposity indicators such as body mass index (BMI), waist circumference (WC), hip circumference, waistâ€“hip ratio and waist height ratio, body adiposity index (BAI) in obese and non-obese female individuals unable to conceive. And also to correlate serum leptin levels with adiposity indicators in infertile females of reproductive age group.

Materials and Methods: Infertile females of reproductive age group were classified as obese and non-obese individuals based on BMI and waistâ€“hip ratio. Serum leptin levels were estimated and correlated with adiposity indicators using Pearson's correlation statistical analysis.

Results: The mean age and duration of infertility were high in obese than the non-obese infertile females. Leptin showed significant positive correlation with WC, waist hip ratio (WHR), and waist/height ratio than the routinely done BMI which had low positive correlation. BAI had mild positive correlation with leptin.

Conclusion: WC and WHR are simple convenient non-invasive tools that can differentiate the type of obesity. Adiposity indicators guide the physician to identify the infertile female individuals who require preliminary steps toward weight reduction before starting the right line of therapy to correct their hormonal imbalance.

Downloads

Download data is not yet available.

References

Adamson PC, Krupp K, Freeman AH, Klausner JD, Reingold AL, Madhivanan P. Prevalence and correlates of primary infertility among young women in Mysore, India. Indian J Med Res 2011;134:440-6.

Kumar D. Prevalence of Female Infertility and its Socio-economic Factors in Tribal Communities of Central India. Rural and Remote Health; 2007. Available from: http://www.rrh.org.au. [Last cited on 2013 Dec 27].

Mithra PP, Kumar P, Kamath VG, Kamath A, Unnikrishnan B, Rekha T, et al. Lifestyle factors and obesity among adolescents in rural South India. Asian J Pharm Clin Res 2015;8:81-3.

Law DC, Maclehose RF, Longnecker MP. Obesity and time of pregnancy. Hum Reprod 2007;22:414-20.

Wise LA, Rothman KJ, Mikkelsen EM, Sorensen HT, Riis A, Hatch EE. An internet based prospective study of body size and time-to-pregnancy. Hum Reprod 2010;25:253-64.

Jungheim ES, Travieso JL, Hopeman MM. Weighing the impact of obesity on female reproductive function and fertility. Nutr Rev 2013;71:3-8.

Kumari P, Jaiswar SP, Shankhwar P, Deo S, Ahmed K, Iqbal S, et al. Leptin as a predictive marker in unexplained infertility in North Indian population. J Clin Diagn Res 2017;11:QC28-31.

Rittenberg V, Seshadri S, Sundara SK, Sobaleva S, Oteng-Ntim E, El-Toukhy T. Effect of body mass index in IVF treatment outcome: An updated systematic review and meta-analysis. Reprod Biomed Online 2011;23:421-39.

Dag ZO, Dilbaz B. Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc 2015;16:111-7.

Freedman DS, Thornton J, Pi-Sunyer FX, Heymsfield SB, Wang J, et al. The body adiposity index (hip circumference Ã· height1.5) is not a more accurate measure of adiposity than is BMI, waist circumference, or hip circumference. Obesity (Silver Spring) 2012;20:2438-44.

Amato MC, Guarnotta V, Forti D, Donatelli M, Dolcimascolo S, Giordano C, et al. Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): A comparative analysis of four simple methods useful for metabolic assessment. Hum Reprod 2013;28:1919-28.

Karoutsos P, Karoutsou E, Karoutsos D. Obesity and female fertility: The bridging role of leptin. J Data Mining Genomics Proteomics 2017;8:209.

Di Yorio MP, Bilbao MG, Biagini-Majorel AM, Faletti AG. Ovarian signalling pathways regulated by leptin during the ovulatory process. Reproduction 2013;146:647-58.

Ali SH, Al-Nuaimi AM, Al-Musawi BM. Serum irisin and leptin levels in obese and non-obese women with polycystic ovary syndrome with reference to glucose homeostasis. Int J Pharm Pharm Sci 2016;8:276 83.

Ebrahimi-Mamaghani M, Saghafi-Asl M, Pirouzpanah S, Aliasgharzadeh A, Aliashrafi S, Rezayi N, et al. Association of insulin resistance with lipid profile, metabolic syndrome, and hormonal aberrations in overweight or obese women with polycystic ovary syndrome. J Health Popul Nutr 2015;33:157-67.

Tsutsumi R, Webster NJ. GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr J 2009;56:729-37.

Nehra J, Kaushal J, Singhal SR, Ghalaut VS. Comparision of myo-inositol versus metformin on anthropometric parameters in polycystic ovarian syndrome in women. Int J Pharm Pharm Sci 2017;9:144-8.

Desai A, Shirode AR, Bhanushali M, Kadam VJ. Assisted reproductive technology (ART): Combating infertility. Asian J Pharm Clin Res 2011;4:18-22.