CURRENT PHARMACOLOGICAL STATUS OF CARDIOPROTECTIVE PLANTS AGAINST ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION
DOI:
https://doi.org/10.22159/ajpcr.2018.v11i4.24158Keywords:
Isoproterenol, Myocardial infarction, CardioprotectiveAbstract
 Objective: Cardiovascular diseases are the major cause of morbidity and mortality in the modern era. Myocardial infarction is a condition where there is a significant decrease or block in the blood (oxygen) supply to the part of heart, leading to degeneration of a portion of the myocardium which triggers a cascade of cellular, inflammatory and biochemical events, leading eventually to the irreversible death (necrosis) of heart muscle cells. Various therapeutic interventions, including lifestyle modification, pharmacological treatment options, and surgical techniques are available. The present review focus on the plants that have been evaluated for cardioprotective activity against isoproterenol-induced myocardial infarction.
Method: The current status of Cardioprotective plants was obtained from a literature search of electronic databases such as Google Scholar, Pubmed and Scopus up to 2017 for publications on medicinal plants used against isoproterenol-induced myocardial infarction. Isoproterenol, Isoprenaline, myocardial infarction, cardioprotective were used as keywords for the searching.
Result: A total of 117 different plant parts and their extracts have till now been published to possess cardioprotection against isoproterenol-induced myocardial infarction. Isoproterenol a beta-adrenergic receptors agonist causes severe stress in myocardium resulting in the infarct-like lesion and produced cardiotoxic effects by elevating the levels of cardiac biomarkers and causing changes in ECG. Plant-based medicines with their antioxidant, antiapoptotic, antihyperlipidemic, platelet antiaggregatory, anti-lipid peroxidation property provide substantial evidence for the management of Ischemia.
Conclusion: This review, therefore, provides a useful resource to enable a thorough assessment of the profile of plants that have cardioprotective activity against isoproterenol-induced myocardial infarction.
Downloads
References
Cardiovascular Diseases (CVDs). World Health Organization. Geneva: World Health Organization; 2017. Available from: http://www.who.int/mediacentre/factsheets/fs317/en.
Silverstein DC, Kate H. Myocardial Infarction. Small Animal Critical Care Medicine. Ch. 41. St Louis, MO: Saunders; 2014. p. 174-6.
Laurence LB, Chabner BA, Knollmann BC, Chabner BA, Knollmann BC. Treatment of myocardial ischemia and hypertension. The Goodman and Gilman’s Manual of Pharmacology and Therapeutics. 12th ed. Ch. 27. New York: McGraw-Hill Medical; 2014. p. 745-65.
Grant WR, Jeffrey ER, Christopher PC. Acute myocardial infarction.Lancet 2017;389:197-210.
Kleinau G, Pratzka J, Nürnberg D, Grüters A, Führer-Sakel D, Krude H, et al. Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists. PLoS One 2011;6:E27073.
Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985;17:291 306.
Bhagat B, Sullivan JM, Fischer VW, Nadel EM, Dhalla NS. CAMP activity and isoproterenol-induced myocardial injury in rats. Recent Adv Stud Cardiac Struct Metab 1976;12:465-70.
Suroowan S, Mahomoodally F. Common phyto-remedies used against cardiovascular diseases and their potential to induce adverse events in cardiovascular patients. Clin Phytosci 2015;1:1.
Senthil MP, Ramprasath T, Selvam S. Cardioprotective role of Acalypha indica extract on isoproterenol induced myocardial infarction in rats. J Pharm Res 2011;4:2129-32.
Shaik E. Evaluation of cardioprotective effect of Achyranthes aspera on isoproterenol induced myocardial infarction in rats. Int J Pharm Biosci 2017;8:124-30.
Kim JH, Chung HS, Antonisamy P, Lee SR, Bae H. Cardioprotective effect of rhizomes of Acorus gramineus against isoproterenol-induced cardiac damage in pigs. Cardiovasc Toxicol 2014;14:183-92.
Ghoneim MA, Hassan AI, Mahmoud MG, Asker MS. Protective effect of Adansonia digitata against isoproterenol-induced myocardial injury in rats. Anim Biotechnol 2016;27:84-95.
Khanna P, Rawri RK, Asdaq SM, Nayeem N, Chakraborty M. Cardioprotective activity of methanolic extract of Aegle marmelos leaf extract against isoproterenol induced myocardial damage in rats. J Pharm Res 2010;9:35-8.
Kharadi GB, Patel KJ, Purohit BM, Baxi SN, Tripathi CB. Evaluation of cardioprotective effect of aqueous extract of Allium cepa Linn. Bulb on isoprenaline-induced myocardial injury in Wistar albino rats. Res Pharm Sci 2016;11:419-27.
Senthilkumar GP, Moses MF, Sengottuvenlu S, Rajarajan T, Sarvanan G. Cardioprotective activity of garlic (Allium sativum) in isoproterenol induced rat myocardial necrosis: A biochemical and histoarchitectural evaluation. Int J Pharm Sci Nanotech 2010;2:779-84.
Pullaiah CP, Venkateswarlu M, Sridhar C, Susma R, Shivarami RY. Evaluation of cardio protective activity of ethanolic extract of Alstonia scholaris on isoproterenol induced myocardial infarction in rats. Int Res J Pharm 2013;4:112-6.
Saravanan G, Ponmurugan P, Sathiyavathi M, Vadivukkarasi S, Sengottuvelu S. Cardioprotective activity of Amaranthus viridis linn: Effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats. Int J Cardiol 2013;165:494-8.
Priya S, Dharamveer P. Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. J Acute Dis 2014;3:228-34.
Adeolu AA, Bisi OA, Ademola AO, Temidayo OO, Momoh AY. Cardioprotective Effects of the ethanol leaf extract of Andrographis paniculata in isoproterenol-induced myocardial infarction in rats. FASEB J 2017;31:1070-12.
Sunmonu TO, Afolayan AJ. Protective effect of Artemisia afra jacq. on isoproterenol-induced myocardial injury in wistar rats. Food Chem Toxicol 2010;48:1969-72.
Xu XL, Ji H, Gu SY, Shao Q, Huang QJ, Cheng YP, et al. Cardioprotective effects of Astragali radix against isoproterenol-induced myocardial injury in rats and its possible mechanism. Phytother Res 2008;22:389 94.
Pitroda KD, Sachdeva PD. Evaluation of cardio protective effect of Averrhoa carambola fruit in isoproterenol induced myocardial infarction in rats. Int J Pharm Sci Res 2016;7:2845-51.
Peer PA, Trivedi PC, Nigade PB, Ghaisas MM, Deshpande AD. Cardioprotective effect of Azadirachta indica A. Juss. On isoprenaline induced myocardial infarction in rats. Int J Cardiol 2008;126:123-6.
Bhaskaran SK, Kannappan P. Protective effect of Azolla microphylla on biochemical, histopathological and molecular changes induced by isoproterenol in rats. Biomed Pharmacother 2017;89:473-81.
Nandave M, Ojha S, Sujata, J, Kumari S, Arya SD. Cardioprotective effect of Bacopa monneira against isoproterenol-induced myocardial necrosis in rats. Int J Pharmacol 2007;3:385-92.
Kuppusamy A, Puliyath J, Muthusamy U, Thirumalaisamy S, Varadharajan S, Arumugam M. Cardioprotective activity of Bixa orellana L. On isoproterenol induced myocardial necrosis in rats. J Pharm Res 2012;5:1930-4.
Jana S, Patel D, Patel S, Upadhyay K, Thadani J, Mandal R, et al. Anthocyanin rich extract of Brassica oleracea L. Alleviates experimentally induced myocardial infarction. PLoS One 2017;12:e0182137.
Raja S, Ramya I. Cardioprotective effect of methanol extract of Buddleja asiatica on isoproterenol induced myocardial necrosis in rats. Der Pharmacia Lett 2017;9:207-16.
Kumar SR, Sharma RK. Cardio protective effect of Caesalpinia crista Linn. on isoproterenol induced myocardial necrosis in rats. Int J Res Pharm Sci 2013;3:119-30.
Sidharth M, Rajesh D, Ravinder K, Sanjeev K. Experimental investigation of marigold extract: Modulates isoproterenol induced myocardial ischemia in rats. Innov Pharm Pharmacother 2016;3:743 57.
Razieh AM, Akhtar M, Atefeh AM, Abul KN. Evaluation of cardioprotective effects of Camellia sinensis on isoproterenol induced myocardial infarction. Int J Pharm Sci Res 2013;4:1056-63.
Manimegalai S, Venkatalakshmi P. Cardioprotective effect of Camellia sinensis Linn., petal extract on isoproterenol induced myocardial infarction in male albino rats. Int J Pharm Sci Res 2012;3:848-52.
Vinay K, Vivek B, Nagarajan K, Lalit M, Umakant B. Protective effects of Centella asiatica against isoproterenol-induced myocardial infarction in rats: Biochemical, mitochondrial and histological findings. J Phytopharmacol 2015;4:80-6.
Mathew G, Lincy J, Sujith K, Minu M. Evaluation of cardioprotective activity of Chonemorpha fragrans alston root extract. Int J Res Pharm Pharm Sci 2017;2:92-5.
Singh BK, Pillai KK, Kohli K, Haque SE. Effect of Cissampelos pareira root extract on isoproterenol-induced cardiac dysfunction. J Nat Med 2013;67:51-60.
Paul S, Das S, Tanvir EM, Hossen MS, Saha M, Afroz R, et al. Protective effects of ethanolic peel and pulp extracts of Citrus macroptera fruit against isoproterenol-induced myocardial infarction in rats. Biomed Pharmacother 2017;94:256-64.
Al-Yahya MA, Mothana RA, Al-Said MS, El-Tahir KE, Al-Sohaibani M, Rafatullah S. Citrus medica Otrojâ€: Attenuates oxidative stress and cardiac dysrhythmia in isoproterenol-induced cardiomyopathy in rats. Nutrients 2013;5:4269-83.
Farogh A, Siddiqui HH, Tarique M, Ritesh KS, Ahmad N. Evaluation of cardioprotective effect of Coleus forskohlii against isoprenaline induced myocardial infarction in rats. Indian J Pharm Biol Res 2014;2:17-25.
Ojha S, Bhatia J, Arora S, Golechha M, Kumari S, Arya DS, et al. Cardioprotective effects of Commiphora mukul against isoprenaline-induced cardiotoxicity: A biochemical and histopathological evaluation. J Environ Biol 2011;32:731-8.
Lakshmi M, Kumar B, Naresh PB. Evaluation of cardioprotective activity of ethanolic extract of Cordia sebestinato against myocardial infarction. Int J Chem Pharm Sci 2017;5:1-6.
Patel DK, Desai SN, Gandhi HP, Devkar RV, Ramachandran AV. Cardio protective effect of Coriandrum sativum L. On isoproterenol induced myocardial necrosis in rats. Food Chem Toxicol 2012;50:3120-5.
Mehdizadeh R, Parizadeh MR, Khooei AR, Mehri S, Hosseinzadeh H. Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats. Iran J Basic Med Sci 2013;16:56-63.
Abi BG, Mohamed SA, Sivakumar V, Jaya SR. Cardioprotective activity of methanolic extract of Croton sparciflorus on isoproterenol induced myocardial infarcted wistar albino rats. J Med Plants Stud 2014;2:1-8.
Thippeswamy BS, Thakker SP, Tubachi S, Kalyani GA, Netra MK, Patil U, et al. Cardioprotective effect of Cucumis trigonus Roxb on isoproterenol-induced myocardial infarction in rat. Am J Pharmacol Toxicol 2009;4:29-37.
Mohanty IR, Arya DS, Gupta SK. Dietary Curcuma longa protects myocardium against isoproterenol induced hemodynamic, biochemical and histopathological alternations in rats. Int J Appl Res Nat Prod 2009;1:19-28.
Khwaja S, Mahmood T, Siddiqui HH. Effect of ethanolic extract of Cyperus rotundus L. against isoprenaline induced cardiotoxicity. Indian J Exp Biol 2016;54:670-5.
Muralidharan P, Balamurugan G, Pavan K. Inotropic and cardioprotective effects of Daucus carota Linn. On isoproterenol-induced myocardial infarction. Bangladesh J Pharmacol 2008;3:74-9.
Divya H, Parthasarathy A, Mathivanan N, Elangovan V. Desmodium gangeticum root extract attenuates isoproterenol-induced cardiac hypertrophic growth in rats. J Pharm Pharm Res 2014;2:129-37.
Jayachandran KS, Vasanthi HR, Rajamanickama GV. Flavonoid rich fraction of Dioscorea bulbifera Linn. (Yam) enhances mitochondrial enzymes and antioxidant status and thereby protects heart from isoproterenol induced myocardial infarction. Curr Pharm Biotechnol 2010;11:887-94.
Sameer NG, Charu S, Umesh BM, Chandragouda RP, Yogeeta OA, Santosh K, et al. Protective effects of cardamom in isoproterenol-induced myocardial infarction in rats. Int J Mol Sci 2015;16:27457-69.
Bhandari U, Ansari MN, Islam F. Cardioprotective effect of aqueous extract of Embelia ribes burm fruits against isoproterenol-induced myocardial infarction in albino rats. Indian J Exp Biol 2008;46:35-40.
Ojha S, Golechha M, Kumari S, Arya DS. Protective effect of Emblica officinalis (Amla) on isoproterenol-induced cardiotoxicity in rats. Toxicol Ind Health 2012;28:399-411.
Santosh KS, Suman BS, Usha RS, Sayeed A, Ankur M, Manmohan M, et al. Eugenia jambolana pretreatment prevents isoproterenol-induced myocardial damage in rats: Evidence from Biochemical, Molecular, and Histopathological Studies. J Med Food 2014;17:244-53.
Anandhi DV, Sowndarya R. Cardioprotective activity of Euphorbia hirta in isoproterenol induced myocardial infarction in rats. J Med Plants Stud 2017;5:330-2.
Sudhakumari, Anil KH, Aamir J, Manish J, Muralidhar ST. Cardioprotective effects in methanolic extract of Evolvulus alsinoides Linn on isoproterenol-induced myocardial infarction in albino rats. Int J Basic Med Sci Pharm 2012;2:53-7.
Karunakar H, Dhruv KK, Keerthi V. Evaluation of cardioprotective activity of aqueous extract of Garcinia indica Linn fruit rind. Asian J Pharm Clin Res 2015;8:107-12.
Ravi M, Padmaja U, Sivanesan S, Sudhakara B. Cardioprotective activity of fruit of Garcinia pedunculata on isoprenaline-induced myocardial infarction in rat. Bangladesh J Pharmacol 2016;11:231-5.
Prabha SP, Nitha A, P Ansil PN, Latha MS. Cardioprotective effect of methanolic extract of Gardenia gummifera Linn. F. On isoproterenol induced myocardial infarction in rats. Int J Pharm Sci Res 2014;5:3817 28.
Panda VS, N SR. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Altern Med Rev 2009;14:161 71.
Radhika S, Smila KH, Muthezhilan R. Cardioprotective activity of Hybanthus enneaspermus (Linn.) On isoproterenol induced rats. Indian J Fundam Appl Life Sci 2011;1:90-7.
Nagasaraswathi M, Rafi KP, Aleemuddin MA, Gopi CK, Sravania K. Effect of Indigofera tinctoria Linn against isoproterenol induced myocardial infarction on albino wistar rats. J Curr Chem Pharm Sci 2012;3:222-30.
Ojha S, Bharti S, Sharma AK, Rani N, Bhatia J, Kumari S, et al. Effect of Inula racemosa root extract on cardiac function and oxidative stress against isoproterenol-induced myocardial infarction. Indian J Biochem Biophys 2011;48:22-8.
Radhika J, Surya S, Jothi G, Japasheba JL. Cardioprotective role of Justicia traquebareinsis Linn. leaf extract in isoproterenol induced myocardial infarction in albino rats. J Appl Pharm Sci 2013;3:124-8.
Dianita R, Jantan I, Amran AZ, Jalil J. Protective effects of Labisia pumila var. Alata on biochemical and histopathological alterations of cardiac muscle cells in isoproterenol-induced myocardial infarction rats. Molecules 2015;20:4746-63.
Upaganlawar A, Balaraman R. Cardioprotective effects of Lagenaria siceraria fruit juice on isoproterenol-induced myocardial infarction in Wistar rats: A Biochemical and histoarchitecture study. J Young Pharm 2011;3:297-303.
Ziaee M, Khorrami A, Ebrahimi M, Nourafcan H, Amiraslanzadeh M, Rameshrad M, et al. Cardioprotective effects of essential oil of Lavandula angustifolia on isoproterenol-induced acute myocardial infarction in rat. Iran J Pharm Res 2015;14:279-89.
Hasitha DM, Srinivasan D, Sengottuvelu S. Cardioprotective activity of Limonia acidissima against isoproterenol induced myocardial infarction in rats. Res J Pharmtech 2016;9:541-4.
Amal D, Kais M, Marwa A, Fatma D, Raouf H, Neji G, et al. Cardioprotective effect of linseed oil against isoproterenol-induced myocardial infarction in Wistar rats: A biochemical and electrocardiographic study. J Physiol Biochem 2015;71:281-8.
Yousefi K, Soraya H, Fathiazad F, Khorrami A, Hamedeyazdan S, Maleki-Dizaji N, et al. Cardioprotective effect of methanolic extract of Marrubium vulgare L. On isoproterenol-induced acute myocardial infarction in rats. Indian J Exp Biol 2013;51:653-60.
Gomathi R, Vijipriya M, Usha K. Cardioprotective effect of ethanolic extract of Medicago sativa stem on isoproterenol induced myocardial infarction in wistar albino rats. Int J Pharm Pharm Sci 2014;6:839-42.
Raish M. Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-κB signaling pathway. Int J Biol Macromol 2017;97:544-51.
Koneri R, Balaraman R, Vinoth K, Hariprasad, Ali A. Cardio protective effect of Momordica cymbalaria Fenzl against experimental myocardial injury induced by Isoproterenol. J Clin Diagn Res 2008;2:699-705.
Nandave M, Ojha SK, Joshi S, Kumari S, Arya DS. Moringa oleifera leaf extract prevents isoproterenol-induced myocardial damage in rats: Evidence for an antioxidant, antiperoxidative, and cardioprotective intervention. J Med Food 2009;12:47-55.
Nade VS, Kawale LA, Bhangale SP, Wale YB. Cardioprotective and antihypertensive potential of Morus alba L. In isoproterenol induced myocardial infarction and renal artery ligation-induced hypertension. J Nat Remed 2013;13:54-67.
Nivethetha M, Jayasri J, Brindha P. Effects of Muntingia calabura L. On isoproterenol-induced myocardial infarction. Singapore Med J 2009;50:300-2.
Subashini R. Cardioprotective efficacy of Nelumbo nucifera leaf extract on glycoprotein, membrane bound atpase and lysosomal enzymes against isoproterenol induced cardiotoxicity in wistar rats. Int J Pharm Pharm Sci 2014;6:537-41.
Al-Taweel AM, Raish M, Perveen S, Fawzy GA, Ahmad A, Ansari MA, et al. Nepeta deflersiana attenuates isoproterenol-induced myocardial injuries in rats: Possible involvement of oxidative stress, apoptosis, inflammation through nuclear factor (NF)-κB downregulation. Phytomedicine 2017;34:67-75.
Gayathri V, Ananthi S, Chandronitha C, Ramakrishnan G, Lakshmisundaram R, Vasanthi HR, et al. Cardioprotective effect of Nerium oleander flower against isoproterenol-induced myocardial oxidative stress in experimental rats. J Cardiovasc Pharmacol Ther 2011;16:96-104.
Murugesan M, Ragunath M, Prabu T, Nadanasabapathi S, Sakthivel M, Manju V. Protective role of Black cumin (Nigella sativa) on isoproterenol induced myocardial infarction in rats. Int J Pharmacol Clin Sci 2012;1:45-53.
Fathiazad F, Matlobi A, Khorrami A, Hamedeyazdan S, Soraya H, Hammami M, et al. Phytochemical screening and evaluation of cardioprotective activity of ethanolic extract of Ocimum basilicum L. (basil) against isoproterenol induced myocardial infarction in rats. Daru 2012;20:87.
Saiprasanna B, Manohar BS, Roja YR, Prasanta KC, Rajeshree P. Cardioprotective activity of Ocimum canum hydro-alcoholic leaf extracts against isoproterenol induced myocardial infarction in rats. Res J Pharmacol Pharmacodyn 2012;4:191-201.
Ramadan G, El-Beih NM, Arafa NM, Zahra MM. Preventive effects of Egyptian sweet marjoram (Origanum majorana L.) leaves on haematological changes and cardiotoxicity in isoproterenol-treated albino rats. Cardiovasc Toxicol 2013;13:100-9.
Abhilash PA, Nisha P, Prathapan A, Nampoothiri SV, Lijo Cherian O, Sunitha TK, et al. Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction. Exp Toxicol Pathol 2011;63:535-40.
Kyu HL, Dukhwan K, Jong-Hoon K. Cardioprotective potential of Korean red ginseng extract on isoproterenol-induced cardiac injury in rats. J Ginseng Res 2013;37:273-82.
Kamala KS, Karthikeyan R, Sengottuvelu S. Pandanus odoratissimus: A potential cardioprotective herb against isoproterenol induced myocardial infarction in rats. Sch Acad J Biosci 2016;4:684-7.
Adi K, Metowogo K, Mouzou A, Lawson-Evi P, Eklu-Gadegbeku K, Agbonon A, et al. Evaluation of cardioprotective effects of Parkia biglobosa (Jacq. Benth) Mimosaceae stem bark. J Appl Pharm Sci 2013;3:60-4.
Al-Yahya M, Raish M, AlSaid MS, Ahmad A, Mothana RA, Al Sohaibani M, et al. ‘Ajwa’ dates (Phoenix dactylifera L.) extract ameliorates isoproterenol-induced cardiomyopathy through downregulation of oxidative, inflammatory and apoptotic molecules in rodent model. Phytomedicine 2016;23:1240-8.
Senthil Kumar SH, Anandan R, Devaki T, Santhosh Kumar M. Cardioprotective effects of Picrorrhiza kurroa against isoproterenol-induced myocardial stress in rats. Fitoterapia 2001;72:402-5.
Arya DS, Arora S, Malik S, Nepal S, Kumari S, Ojha S, et al. Effect of Piper betle on cardiac function, marker enzymes, and oxidative stress in isoproterenol-induced cardiotoxicity in rats. Toxicol Mech Methods 2010;20:564-71.
Khushbu C, Lalkrishna P, Roshni S, Virendra K, Dhaval M, Timir P. Effect of Piper longum Linn on histopathological and biochemical changes in isoproterenol induced myocardial infarction in rats. Res J Pharm Biol Chem Sci 2010;1:759-66.
Raja S, Ramya I. Cardioprotective potential of methanol extract of Polygonum glabrum on isoproterenol induced myocardial necrosis in rats. Int J Phytomed 2017;9:518-27.
Behera S, Manohar BS, Roja RY, Choudhury PK, Panigrahi R. Cardioprotective effect of Pongamia pinnata hydro-alcoholic leaf extract against isoproterenol induced myocardial infarction in wistar albino rats. Int J Med Pharm Sci 2013;2:1-15.
Mahalaxmi M, Pankaj P, Prakash G, Sanjay K. Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats. J Pharmacol Pharmacother 2010;1:32-7.
Shahat AA, Alsaid MS, Rafatullah S, Al-Sohaibani MO, Parvez MK, Al-Dosari MS, et al. Treatment with Rhus tripartita extract curtails isoproterenol-elicited cardiotoxicity and oxidative stress in rats. BMC Complement Altern Med 2016;16:351.
Hu Y, Guo DH, Liu P, Rahman K, Wang DX, Wang B, et al. Antioxidant effects of a Rhodobryum roseum extract and its active components in isoproterenol-induced myocardial injury in rats and cardiac myocytes against oxidative stress-triggered damage. Pharmazie 2009;64:53-7.
Manjunatha PM, Sandip K, Divakar G. Preventive effect of Rhododendron arboreum on cardiac markers, lipid peroxides and antioxidants in normal and isoproterenol-induced myocardial necrosis in rats. Afr J Pharm Pharmacol 2011;5:755-63.
Geng ZH, Huang L, Song MB, Song YM. Protective effect of a polysaccharide from Salvia miltiorrhiza on isoproterenol (ISO)-induced myocardial injury in rats. Carbohydr Polym 2015;132:638 42.
Mohamed ST, Lokanath N, Prasanthi A, Madhavi M, Mallika G, Vishnu MN. Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats. J Adv Pharm Tech Res 2013;4:94-100.
Kosanam N, Rabindra D, Firdous SM. Cardioprotective activity of fruits of Sechium edule. Bangladesh J Pharmacol 2015;10:125-30.
Ramadoss S, Kannan K, Balamurugan K, Jeganathan NS, Manavalan R. Efficacy of cardioprotective effects in ethanolic extract of Sida rhombifolia Linn. On isoproterenol-induced myocardial infarction in albino rats. Res J Pharm Biol Chem Sci 2012;3:488-93.
Asdaq SM, Chakraborty M. Myocardial potency of Semecarpus anacardium Nut extract against isoproterenol induced myocardial damage in rats. Int J Pharm Sci Rev Res 2010;2:10-3.
Aman U, Vaibhav P, Balaraman R. Tomato lycopene attenuates myocardial infarction induced by isoproterenol: Electrocardiographic, biochemical and anti-apoptotic study. Asian Pac J Trop Biomed 2012;2:345-51.
Sameer AS, Shivaprasad H, Asra F, Preran KH, Syeda JF, Farhath K. Cardio protective effect of Solanum nigrum Linn. in isoproterenol induced myocardial infarction in rat. Sci Technol Arts Res J 2015;4:77 82.
Chitikela PP, Dhanunjaya S, Narasimha KG, Pichaiah D, Venkateswarlu M, Ranganayakulu D. Impact of Solanum surettense on membrane bound Na+/K+ ATPase and in vivo anti-oxidants activity on isoproterenol induced myocardial injury in rats. J Phytopharmacol 2015;4:139-42.
Victor AD, Suresh S, Sowndarya R. Evaluation of cardioprotective activity of Solanum torvum in isoproterenol induced rats. World J Pharm Pharm Sci 2016;5:1633-9.
Victor AD, Nancy B, Sowndarya R. Cardioprotective activity of Solanum xanthocarpum in isoproterenol induced myocardial infarction in rats. Int J Pharm Pharm Res 2016;6:371-6.
Siddiq A, Shanmukha I, Jyoti TM, Kamlesh G. Cardioprotective effect of Spathodea campanulata bark on isoproterenol-induced myocardial infarction in rats. Asian Pac J Trop Dis 2012;2:S1-5.
Akinmoladun AC, Obuotor EM, Barthwal MK, Dikshit M, Farombi EO. Ramipril-like activity of Spondias mombin linn against no-flow ischemia and isoproterenol-induced cardiotoxicity in rat heart. Cardiovasc Toxicol 2010;10:295-305.
Nabeel K, Manjula SN, Mruthunjaya K, Mahalakshmi AM. Cardio protective effect of Tamarindus indica. Linn against isoproterenol induced myocardial infarction in rats. Int J Pharm Pharm Sci 2016;8:254-60.
Shanmukha I, Vijay KM, Ramachandra SS. Cardioprotective effect of hydroalcoholic extract of Tecoma stans flowers against isoproterenol induced myocardial infarction in rats. Asian Pac J Trop Dis 2014;4:S378-84.
Sivakumar V, Rajeshkumar S. Screening of cardioprotective effect of Terminalia arjuna Linn. Bark in isoproterenol-Induced myocardial infarction in experimental animals. Int J Pharm Sci Res 2014;5:262-8.
Suchalatha S, Shyamala Devi CS. Protective effect of Terminalia chebula against experimental myocardial injury induced by isoproterenol. Indian J Exp Biol 2004;42:174-8.
Shaik AH, Rasool SN, Vikram KR, Abdul KM, Saayi KG, Lakshmi DK. Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats. J Ethnopharmacol 2012;141:33 40.
Alam F, Siddiqui HH. Cardioprotective Activity of Terminelia belerica on isoprenaline induced myocardial necrosis in rat. Asian J Chem Pharm Res 2014;2:127-36.
Neha K, Lubna A. Evaluation of cardioprotective effect of Tinospora cordifolia against isoprenaline induced myocardial infarction in rats. Int J Curr Microbiol Appl Sci 2014;3:543-55.
Ipseeta RM, Ujjwala M, Daniel J, Yeswant D. Tribulus terrestris protects rat myocardium against isoproterenol-induced ischemic injury: Role of HSP 70 and cardiac endogenous antioxidants. Alternat Med Stud 2011;1:35-9.
Sivanandham V, Selvarani S, Adhithan A. Cardioprotective effect of Trichopus zeylanicus against myocardial ischemia induced by isoproterenol in rats. Bangladesh J Pharmacol 2009;4:88-91.
Deepika E, Sivakumar V, Selvapriya B, Dinesh K, Mohamed SA. Phytochemical screening and evaluation of cardioprotective activity of ethanolic extract of Trigonella foenum-graecum against isoproterenol induced myocardial infarction rats. Int J Pharm Res Sch 2014;3:146 54.
Barman NR, Nandy S, Datta R, Kar PK. Cardioprotective effect of ethanolic extract of Urtica parviflora roxb. Against isoproterenol induced myocardial infarction in rats. Indian J Pharmacol 2013;45:513 6.
Mahesh KK, Nelson SK, Rajaram C, Rupesh SK, Ravindra KR. Evaluation of Cardioprotective effect of methanolic extract of Ventilago maderaspatana against isoproterenol induced myocardial infarction in experimental rats. Int J Adv Pharm Res 2012;3:1167-76.
Prasad EM, Mopuri R, Islam MS, Kodidhela LD. Cardioprotective effect of Vitex negundo on isoproterenol-induced myocardial necrosis in wistar rats: A dual approach study. Biomed Pharmacother 2017;85:601-10.
Velavan S, Aegil I, Gokulakrishnan K. Protective effect of Vitis vinifera against myocardial ischemia induced by isoproterenol in rats. Pharmacol Online 2008;3:958-67.
Monisha MS, Ragavan B, Rex DA. Cardioprotective potential of Wedelia chinensi on isoproterenol induced myocardial rat. Asian J Biochem 2014;9:98-106.
Khalil MI, Ahmmed I, Ahmed R, Tanvir EM, Afroz R, Paul S, et al. Amelioration of isoproterenol-induced oxidative damage in rat myocardium by Withania somnifera leaf extract. Biomed Res Int 2015;2015:624159.
Amran AZ, Jantan I, Dianita R, Buang F. Protective effects of the standardized extract of Zingiber officinale on myocardium against isoproterenol-induced biochemical and histopathological alterations in rats. Pharm Biol 2015;53:1795-802.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
