HUMAN PAPILLOMAVIRUS AND ITS NATURE OF INFECTION: AN OVERVIEW

Ranit Das; Vijay Mishra; Neha Sharma; Navneet Khurana

doi:10.22159/ajpcr.2018.v11i6.24233

Authors

Ranit Das School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Vijay Mishra School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Neha Sharma School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Navneet Khurana School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i6.24233

Keywords:

Human papillomavirus infection, Cancers, Human papillomavirus vaccines, Respiratory papillomatosis, Epidermodysplasia verruciformis

Abstract

Human papillomavirus (HPV) belonging to Papillomaviridae (family of Papillomavirus). HPV infection causes various types of disorders and diseases including cervical, vaginal, anal, penile, oropharyngeal, and lung cancer also cancer in head and neck along with some malignant and benign warts. HPV also found to be responsible for respiratory papillomatosis. Epidermodysplasia verruciformis, an orphan disease termed as tree man disease, is also occurred by the HPV infection. Vaccines show benefit nowadays. Some surgery and adjuvant therapy is also showing response in the treatment of HPV caused cancers. In this abstract, we summarized the types, structures, genomic organization, mode of transmission of the virus along with type of infections, and protection and modern treatment approaches.

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Author Biographies

Ranit Das, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Research Scholar, Department of Pharmacology

Vijay Mishra, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Assistant Professor, Department of Pharmaceutics

Neha Sharma, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Assistant Professor, Department of Pharmacology

Navneet Khurana, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.

Assistant Professor, Department of Pharmacology

References

Milner DA. Diagnostic pathology: Infectious diseases. Philadelphia, PA: Elsevier Health Sciences; 2015.

Centers for Disease Control and Prevention (CDCP). What is HPV? Available from: https://www.cdc.gov/hpv/parents/whatishpv.html. [Last retrieved on 2017 Aug 10].

de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H. Classification of papillomaviruses. Virology 2004;324:17-27.

Herbst LH, Lenz J, Van Doorslaer K, Chen Z, Stacy BA, Wellehan JF Jr, et al. Genomic characterization of two novel reptilian papillomaviruses, Chelonia mydas papillomavirus 1 and caretta caretta papillomavirus 1. Virology 2009;383:131-5.

Drury SE, Gough RE, McArthur S, Jessop M. Detection of herpesvirus-like and papillomavirus-like particles associated with diseases of tortoises. Vet Rec 1998;143:639.

Lange CE, Favrot C, Ackermann M, Gull J, Vetsch E, Tobler K. Novel snake papillomavirus does not cluster with other non-mammalian papillomaviruses. Virol J 2011;8:436.

Gottschling M, GÃ¶ker M, Stamatakis A, Bininda-Emonds OR, Nindl I, Bravo IG, et al. Quantifying the phylodynamic forces driving papillomavirus evolution. Mol Biol Evol 2011;28:2101-13.

Ho L, Chan SY, Burk RD, Das BC, Fujinaga K, Icenogle JP, et al. The genetic drift of human papillomavirus Type 16 is a means of reconstructing prehistoric viral spread and the movement of ancient human populations. J Virol 1993;67:6413-23.

Calleja-Macias IE, Villa LL, Prado JC, Kalantari M, Allan B, Williamson AL, et al. Worldwide genomic diversity of the high-risk human papillomavirus Types 31, 35, 52, and 58, four close relatives of human papillomavirus Type 16. J Virol 2015;79:13630-40.

Van Ranst M, Fuse A, Fiten P, Beuken E, Pfister H, Burk RD, et al. Human papillomavirus Type 13 and pygmy chimpanzee papillomavirus Type 1: Comparison of the genome organizations. J Virol 1992;190:587- 96.

Rayment I, Baker TS, Caspar DL, Murakami WT. Polyoma virus capsid structure at 22.5 A resolution. Nature 1982;295:110-5.

Zheng ZM, Baker CC. Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci 2006;11:2286-302.

Tang S, Tao M, McCoy JP, Zheng ZM. The E7 oncoprotein is translated from spliced E6* I transcripts in high-risk human papillomavirus Type 16-or Type 18-positive cervical cancer cell lines via translation reinitiation. J Virol 2006;80:4249-63.

Schiller JT, Day PM, Kines RC. Current understanding of the mechanism of HPV infection. Gynecol Oncol 2010;118:S12-7.

Joyce JG, Tung JS, Przysiecki CT, Cook JC, Lehman ED, Sands JA, et al. The L1 major capsid protein of human papillomavirus Type 11 recombinant virus-like particles interacts with heparin and cell-surface glycosaminoglycans on human keratinocytes. J Biol Chem 1992;274:5810-22.

World Health Organization (WHO). Human Papillomavirus (HPV) and Cervical Cancer. Available from: http://www.who.int/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer. [Last retrieved on 2016 Aug 10].

Ljubojevic S, Skerlev M. HPV-associated diseases. Clin Dermatol 2014;32:227-34.

Burchell AN, Winer RL, de SanjosÃ© S, Franco EL. Epidemiology and transmission dynamics of genital HPV infection. Vaccine 2006;24 Suppl 3:52-61.

Schmitt M, Depuydt C, Benoy I, Bogers J, Antoine J, Arbyn M, et al. Prevalence and viral load of 51 genital human papillomavirus types and 3 subtypes. Int J Cancer 2013;132:2395-403.

MuÃ±oz N, Bosch FX, de SanjosÃ© S, Herrero R, CastellsaguÃ© X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518-27.

Sinal SH, Woods CR. Human papillomavirus infections of the genital and respiratory tracts in young children. Semin Pediatr Infect Dis 2005;16:306-16.

Bodaghi S, Wood LV, Roby G, Ryder C, Steinberg SM, Zheng ZM, et al. Could human papillomaviruses be spread through blood? J Clin Microbiol 2005;43:5428-34.

Chen AC, Keleher A, Kedda MA, Spurdle AB, McMillan NA, Antonsson A, et al. Human papillomavirus DNA detected in peripheral blood samples from healthy Australian male blood donors. J Med Virol 2009;81:1792-6.

Krueger H, Stuart G, Gallagher R, Williams D. HPV and Other Infectious Agents in Cancer: Opportunities for Prevention and Public Health. New York (NY): Oxford University Press; 2010.

Hernandez BY, Wilkens LR, Zhu X, Thompson P, McDuffie K, Shvetsov YB, et al. Transmission of human papillomavirus in heterosexual couples. Emerg Infect Dis 2008;14:888-94.

Tay SK. Genital oncogenic human papillomavirus infection: A short review on the mode of transmission. Ann Acad Med Singapore 1995;24:598-601.

Watson RA. Human papillomavirus: Confronting the epidemic-A urologistâ€™s perspective. Rev Urol 2005;7:135-44.

Alam S, Conway MJ, Chen HS, Meyers C. The cigarette smoke carcinogen benzo[a]pyrene enhances human papillomavirus synthesis. J Virol 2008;82:1053-8.

Baseman JG, Koutsky LA. The epidemiology of human papillomavirus infections. J Clin Virol 2005;32 Suppl 1:S16-24.

Bolt J, Vo QN, Kim WJ, McWhorter AJ, Thomson J, Hagensee ME, et al. The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms. Oral Oncol 2005;41:1013-20.

Greenblatt RJ. Human papillomaviruses: Diseases, diagnosis, and a possible vaccine. Clin Microbiol Newslett 2005;27:139-45.

Frisch M, Smith E, Grulich A, Johansen C. Cancer in a population-based cohort of men and women in registered homosexual partnerships. Am J Epidemiol 2003;157:966-72.

Gaither TW, Truesdale M, Harris CR, Alwaal A, Shindel AW, Allen IE, et al. The influence of sexual orientation and sexual role on male grooming-related injuries and infections. J Sex Med 2005;12:631-40.

Chaturvedi A, Gillison ML. Human papillomavirus and head and neck cancer. In: Olshan AF, editor. Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer. 1st ed. New York: Springer; 2010.

Maxwell JH, Kumar B, Feng FY, Worden FP, Lee JS, Eisbruch A, et al. Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res 2010;16:1226-35.

American Association for Cancer Research (AACR). Lung Cancer Risk Rises in the Presence of HPV Antibodies; 2011. Available from: http:// www.aacr.org.

SyrjÃ¤nen K, SyrjÃ¤nen S, Kellokoski J, KÃ¤rjÃ¤ J, MÃ¤ntyjÃ¤rvi R. Human papillomavirus (HPV) Type 6 and 16 DNA sequences in bronchial squamous cell carcinomas demonstrated by in situ DNA hybridization. Lung 1989;167:33-42.

Dâ€™Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007;356:1944-56.

Koning MN, Quint KD, Bruggink SC, Gussekloo J, Bouwes Bavinck JN, Feltkamp MC, et al. High prevalence of cutaneous warts in elementary school children and ubiquitous presence of wart-associated HPV on clinically normal skin. Br J Dermatol 2014;172:196-201.

Greer CE, Wheeler CM, Ladner MB, Beutner K, Coyne MY, Liang H, et al. Human papillomavirus (HPV) type distribution and serological response to HPV type 6 virus-like particles in patients with genital warts. J Clin Microbiol 1995;33:2058-63.

World Health Organization (WHO). World Cancer Report 2014. Ch. 5,12. Geneva: World Health Organization; 2014.

Lazarczyk M, Pons C, Mendoza JA, Cassonnet P, Jacob Y, Favre M, et al. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. J Exp Med 2008;205:35-42.

Food and Drug Administration (FDA). Available from: http://www.fda. gov/NewsEvents/Newsroom/PressAnnouncements/ucm426485.htm. [Last retrieved on 2016 Jan 30].

Human Papillomavirus Epidemiology and Prevention of Vaccine- Preventable Diseases. Available from: http://www.Cdc.gov. [Last retrieved on 2016 Jan 30].

CDC. Condom Effectiveness-Male Latex Condoms and Sexually Transmitted Diseases. Centers for Disease Control and Prevention (CDC); 2009. Available from: https://www.cdc.gov/condomeffectiveness/docs/ condoms_and_stds.pdf. [Last retrieved on 2016 Jan 30].

Pathogen Safety Data Sheet (PSDS)-Infectious Substances. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/papillome-eng. php. [Last retrieved on 2016 Jan 30].

Centers for Disease Control and Prevention (CDC). Genital HPV Infection Fact Sheet; 2008. Available from: https://stacks.cdc.gov/view/ cdc/26043. [Last retrieved on 2016 Jan 30].

Kaczmar JM, Tan KS, Heitjan DF, Lin A, Ahn PH, Newman JG, et al. HPV-related oropharyngeal cancer: Risk factors for treatment failure in patients managed with primary transoral robotic surgery. Head Neck 2016;38:59-65.

Bratcher FL, Sahasrabuddhe VV. R Tehvieew impact of antiretroviral therapy on HPV and cervical intraepithelial neoplasia: Current evidence and directions for future research. Infect Agents Cancer 2010;5:8.

Praveena P, Jethinlalkhosh JP, Doss VA. Pharmacological evaluation of antineoplastic activity of hydroethanolic extract of unripe fruit of Carica papaya linn using animal model. Asian J Pharm Clin Res 2017;10:179.

Grimes JL. HPV vaccine development: A case study of prevention and politics. Biochem Mol Biol Educ 2006;34:148-54.

Gunalan G, Krishnamurthy V. Impact of radiotherapy on oxidative stress in neutrophils of cervical cancer patients. Asian J Pharm Clin Res 2012;5:65.