IN VITRO STUDY OF ANTITRYPANOSOMAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF GARCINIA KOLA AGAINST TRYPANOSOMA BRUCEI BRUCEI

Authors

  • Ali Sani Department of Biological Sciences, Bayero University, Kano, Nigeria.
  • Umar Abdullahi Zakariyya Department of Biochemistry, Federal University Dutse, Jigawa, Nigeria.
  • Asmau Mahe Department of Biochemistry, Federal University Dutse, Jigawa, Nigeria.
  • Deepa Singh Department of Medical Sciences, American International Institute of Medical Sciences, Udaipur, Rajasthan, India.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i6.25022

Keywords:

Garcinia kola, Phytochemicals, Trypanosomiasis, Trypanosoma brucei brucei

Abstract

Objective: The study was aimed at evaluating in vitro antitrypanosomal activity of Garcinia kola against Trypanosoma brucei brucei.

Methods: The plant materials were extracted and screened for phytochemicals. The antitrypanosomal activity of 70% and 100% G. kola extracts against the parasite was determined in vitro.

Results: Both extracts contained saponins, tannins, carbohydrates, cardiac glycosides, and flavonoids. However, anthraquinones and alkaloids were undetected. The parasites were seen to be actively motile within the first 30 min post-incubation period in 70% hydroethanolic G. kola extract and were found dead at 40–60 min in a higher concentration of extract. After 10 min post-incubation of the parasites in 100% ethanolic extract of G. kola, the parasites were observed to be active at lower concentration but at higher concentrations of the extracts, no trypanosomes were seen.

Conclusion: 100% extract induces ceasing of motility at the lesser time compared to 70% ethanolic extract. Similarly, the effect increases with increase in extract concentration. Further research should be carried out to elucidate the bioactive compounds present to have a broad knowledge on the mode of action of the compounds.

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Author Biography

Ali Sani, Department of Biological Sciences, Bayero University, Kano, Nigeria.

Lecturer, Department of Biological Sciences

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Published

07-06-2018

How to Cite

Sani, A., U. A. Zakariyya, A. Mahe, and D. Singh. “IN VITRO STUDY OF ANTITRYPANOSOMAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF GARCINIA KOLA AGAINST TRYPANOSOMA BRUCEI BRUCEI”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 6, June 2018, pp. 417-9, doi:10.22159/ajpcr.2018.v11i6.25022.

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