EVALUATION OF ANTHELMINTIC ACTIVITY OF MOMORDICA CHARANTIA, CUCURBITA PEPO L., AND SOLANUM TORVUM BASED FORMULATION AND ITS PHYTOCHEMICAL ANALYSIS USING FOURIER TRANSFORM INFRARED

Jannathul Firdous; Bharathi V; Noorzaid Muhamad

doi:10.22159/ajpcr.2018.v11i7.25806

Authors

Jannathul Firdous Department of Preclinical, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia.
Bharathi V Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, Tamil Nadu, India.
Noorzaid Muhamad Student Development Division, Universiti Kuala Lumpur Royal College of Medicine Perak, Jalan Greentown, 30450 Ipoh, Perak, Malaysia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i7.25806

Keywords:

Anthelmintic action, Fourier transform infrared, Gastrointestinal parasites, Livestock, Phytochemicals

Abstract

Objective: In the present study, the phytochemical and anthelmintic effect of a formulation (MCS) prepared from the plants, namely Momordica charantia, Cucurbita pepo L., and Solanum torvum were investigated.

Methods: Phytochemical constituents were analyzed using Fourier transform infrared (FTIR), and anthelmintic activity of methanolic and aqueous extract MCS formulation against earthworm Pheretima posthuma was evaluated.

Result: As a result of FTIR analysis, MCS formulation showed the presence of coumarin, flavonoids, tannin, phenolic compound, saponin, quinone, and alkaloids. In investigating the anthelmintic action of formulation against adult Indian earthworms, the values of paralytic time and death time of formulation were less when compared to the positive control albendazole.

Conclusion: The present work concludes that the MCS formulation acts as a more suitable herbal treatment against helminths infection.

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