RELAXATION EFFECT OF ETHANOLIC EXTRACT OF AVERRHOA BILIMBI L. LEAVES ON ILEUM SMOOTH MUSCLE CONTRACTION OF IN VITRO ISOLATED RAT (RATTUS NORVEGICUS)

Rulia Meilina; Edy Suwarso; Aminah Dalimunthe

doi:10.22159/ajpcr.2018.v11s1.26588

Authors

Rulia Meilina Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Edy Suwarso Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Aminah Dalimunthe Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26588

Keywords:

Averrhoa bilimbi L, Serotonin (5-HT), 5-HT3 receptor, Ethanolic extract

Abstract

Objective: The study was aimed to investigate the relaxation effect of ethanolic extract of Averrhoa bilimbi L. leaves (EEABL) and ondansetron against 5-HT-induced contraction of the 5-HT3 receptor.

Methods: The study of the relaxation effect of the cumulative concentration EEABL leaves (0.5â€“4 mg/mL) and ondansetron (10âˆ’5â€“3Ã—10âˆ’2) after the contracted with 5-HT (EC80: 1.158Ã—10âˆ’6 M) was conducted in vitro using isolated rat's ileum organ in the Tyrode solution.

Results: The EEABL and ondansetron decreased ileum contraction after induced by 5- HT. EEABL has no difference in terms of ability as ondansetron in reducing the ileum smooth muscle contraction induced by 5-HT (p>0.05).

Conclusion: The EEABL has relaxation effect on smooth muscle of rat's isolated ileum which has induced by 5-HT.

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