CORRELATION OF TYPE-2 DIABETES MELLITUS AND DYSLIPIDEMIA AMONG NEPALESE
Abstract
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 Objectives: More cardiovascular disease occurs in patients with either Type 1 diabetes mellitus (DM) or Type 2 DM (T2DM). Serum high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol profiles in T2DM is quite useful, as it may serve as a reliable monitor to judge the prognosis of the patients. The aim of the present study is to examine T2DM and dyslipidemia and their correlation in residents of Nepal. The detection of risk factors in the early stage of the disease will help the patients to improve and reduce the morbidity rate as LDL promotes cholesterol deposition in the arterial wall.
Methods: This case-control study was carried out in Lumbini Medical College, Palpa, Nepal, on total of 100 subjects, with 50 controls (non-diabetic cases) and 50 T2DM patients, to study their HDL and LDL profiles.
Results: The present study showed increased levels of fasting blood sugar (164.5 [51.17] than in control 95.4 [10.09]) and LDL cholesterol (121.4 [27.89] than in control 103.6 [30.67]) in T2DM subjects; conversely, serum HDL cholesterol (39.2 [7.96]) level was reduced significantly in T2DM patients (than in controls 44.0 [10.57]).
Conclusion: Thus, the findings of the present study imply a significant correlation between serum HDL and LDL cholesterols in T2DM subjects.
Keywords: Blood glucose, Cholesterol, High density lipoprotein, Low density lipoprotein, Non-insulin dependent diabetes mellitus
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Proces S, Delgrange E, Vander Borght TV, Jamart J, Donckier JE. Minor alterations in thyroid-function tests associated with diabetes mellitus and obesity in outpatients without known thyroid illness. Acta Clin Belg 2001;56(2):86-90.
Bhattarai T, Bhattacharya K, Chaudhuri P, Sengupta P. Correlation of common biochemical markers for bone turnover, serum calcium, and alkaline phosphatase in post-menopausal women. Malays J Med Sci 2014;21(1):58-61.
Hamman RF. Genetic and environmental determinants on non-insulin-dependant-diabetes mellitus (NIDDM). Diabetes Metab Rev 2009;8:287-337.
Suryawanshi NP, Bhutey AK, Nagdeote AN, Jadhav AA, Manoorkar GS. Study of lipid peroxide and lipid profile in diabetes mellitus. Indian J Clin Biochem 2006;21(1):126-30.
Wägner AM, Sánchez-Quesada JL, Pérez A, Rigla M, Cortés M, Blanco-Vaca F, et al. Inaccuracy of calculated LDL-cholesterol in type 2 diabetes: Consequences for patient risk classification and therapeutic decisions. Clin Chem 2000;46(11):1830-2.
Solano MP, Goldberg RB. Lipid management in type-2 diabetes. Am Diabetes Assoc Clin Diabetes 2006;24:27-32.
Nieuwdorp M, Vergeer M, Bisoendial RJ, op ‘t Roodt J, Levels H, Birjmohun RS, et al. Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitus. Diabetologia 2008;51(6):1081-4.
Ugwa CE, Ezeanyika LU, Daikwo MA, Amana R. Lipid profile of a population of diabetic patients attending Nigerian National Petrolium Corporation Clinic, Abuja. Afr J Biochem Res 2009;3:066-9.
Kumar A, Tewari P, Sahoo SS, Srivastava AK. Prevalence of insulin resistance in first degree relatives of type-2 diabetes mellitus patients: A prospective study in north Indian population. Indian J Clin Biochem 2005;20(2):10-7.
WHO. Diabetes Mellitus. Technical Report Series No. 646. Geneva: WHO; 1985.
Nakhjavani M, Esteghamati AR, Esfahanian F, Heshmat AR. Dyslipidemia in type 2 diabetes mellitus: More atherogenic lipid profile in women. Acta Med Iran 2006;44:111-8.
Bhatti SM, Dhakam S, Khan A. Trends of lipid abnormalities in Pakistani type-2 diabetes mellitus patients: A tertiary care centre data. Pak J Med Sci 2009;25:883-9.
Deeg R, Ziegenhorn J. Kinetic enzymic method for automated determination of total cholesterol in serum. Clin Chem 1983;29(10):1798-802.
Bachorik PS. Measurement of low density lipoprotein cholestrol. In: Rifal N, Wrnick GR, Dominicak MH, editors. Hand Book Lipoprotein Testing. Washington: AACC Press; 1997. p. 145-60.
Rosner B. Fundamentals of Biostatistics. 5th ed. Pacific Grove, CA: Duxbury; 2000. p. 80-240.
Rao S, Richard J. An Introduction to Biostatistics: A Manual for Students in Health Sciences. New Delhi: Prentice Hall of India; 2006. p. 86-160.
Bhalla K, Shukla R, Gupta VP, Puyazhenthi S, Prabhu KM. Glycosylated proteins and serum lipid profile in complicated and complicated NIDDM patients. Indian J Clin Biochem 1995;10:57-61.
Bhattacharya K. Ovulation and rate of implantation following unilateral ovariectomy in mice. J Hum Reprod Sci 2013;6(1):45-8.
Chandra KA, Sengupta P, Goswami H, Sarkar M. Excessive dietary calcium in the disruption of structural and functional status of adult male reproductive system in rat with possible mechanism. Mol Cell Biochem 2012;364(1-2):181-91.
Bhattarai T, Chaudhuri P, Bhattacharya K, Sengupta P. Effect of progesterone supplementation on post-coital unilaterally ovary ectomized superovulated mice in relation to implantation and pregnancy. Asian J Pharm Clin Res 2014;7(1):29-31.
Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire-Buys D, et al. Experimental NIDDM: Development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 1998;47(2):224-9.
Idogun ES, Unuigbe EI, Ogunuro PS, Akinola OT, Famodu AA. Assessment of serum lipids in Nigerians with type-2 diabetes mellitus complications. Pak J Med Sci 2007;23(5):708-12.
Dowse GK, Gareeboo H, Zimmet PZ, Alberti KG, Tuomilehto J, Fareed D, et al. High prevalence of NIDDM and impaired glucose tolerance in Indian, Creole, and Chinese Mauritians. Mauritius Noncommunicable Disease Study Group. Diabetes 1990;39(3):390-6.
Yegin A, Ozben T. Serum glycated lipoproteins in type II diabetic patients with and without complications. Ann Clin Biochem 1995;32:459-63.
Panteghini M, Cimino A, Pagani F, Girelli A. Nonenzymic glycation of apolipoprotein B in patients with insulin- and noninsulin-dependent diabetes mellitus. Clin Biochem 1995;28(6):587-92.
Frier BM, Saudek CD. Cholesterol metabolism in diabetes: The effect of insulin on the kinetics of plasma squalene. J Clin Endocrinol Metab 1979;49(6):824-9.
Singh U, Singh S, Kocchar A. Therapeutic potential of antidiabetic nutraceutical. Phytopharmacology 2012;2:144-69.
Sengupta P, Sahoo S. A cross sectional study to evaluate the fitness pattern among the young fishermen of coastal Orissa. Indian J Public Health Res Dev 2013;4(1):171-5.
Harno K, Nikkila EA, Kussi T. Metabolism of cholesterol and post heparin plasma hepatic endothelial lipase activity: Relationship to obesity and non-insulin dependent diabetes mellitus. Diabetologia 1980;19:28.
Glomset JA. The plasma lecithins: Cholesterol acyltransferase reaction. J Lipid Res 1968;9(2):155-67.
Del-Yassin H, Hasso NM, Aal-Rubayi A. Lipid profile and lipid peroxidation pattern pre and post exercise in coronary heart disease. Turk J Med Sci 2005;53:223-8.
Nathan DM. Clinical practice. Initial management of glycemia in type 2 diabetes mellitus. N Engl J Med 2002;347(17):1342-9.
Wu JH, Hsieh RP, Chern MS, Wen MS, Tseng CH. Association of 1617 C --> T genetic variation in exon 11 of human low-density lipoprotein receptor and plasma lipid concentration. Atherosclerosis 1999;143(1):217-8.
Goolay A, Zech L, Shi MZ. High density lipoprotein turnover in noninsulin dependent diabetes mellitus. Diabetes 1985;34:81A.
Chandra AK, Goswami H, Sengupta P. Dietary calcium induced cytological and biochemical changes in thyroid. Environ Toxicol Pharmacol 2012;34(2):454-65.
Krajewska-Kulak E, Sengupta P. Thyroid function in male infertility. Front Endocrinol (Lausanne) 2013;4:174.
Chandra AK, Goswami H, Sengupta P. Effects of magnesium on cytomorphology and enzyme activities in thyroid of rats. Indian J Exp Biol 2014;52(8):787-92.
Schmitt JK, Poole JR, Lewis SB, Shore VG, Maman A, Baer RM, et al. Hemoglobin A1 correlates with the ratio of low-to high-density-lipoprotein cholesterol in normal weight type II diabetics. Metabolism 1982;31(11):1084-9.
Sengupta P. The laboratory rat: Relating its age with human’s. Int J Prev Med 2013;4(6):624-30.
Singla S, Kaur K, Kaur G, Kaur H, Kaur J, Jaswal S. Lipoprotein (a) in type 2 diabetes mellitus: Relation to LDL: HDL ratio and glycemic control. Int J Diabetes Dev Ctries 2009;29(2):80-4.
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