ANTIDIABETIC AND HYPOLIPIDEMIC EFFECTS OF METHANOLIC EXTRACT OF VENTILAGO MADERASPATANA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Abstract

This study evaluated methanolic extract of Ventilago maderaspatana (MVM) on reducing hyperglycemia and hyperlipidemia in streptozotocin -induced diabetic rats. MVM was orally administered once a day after 3 days of streptozotocin -induction at 100,200 and 400 mg/kg for 45 day and the results showed that serum fasting blood glucose, glucose – 6 – phosphotase , fructose 1, 6 –phosphotase in hepatic tissues ,total cholesterol,, free fatty acids and triglyceride in serum, HbA1c in blood levels were significantly decreased, whereas haemoglobulin in blood  and serum high density lipoprotein, glucokinase, glucose – 6 – Phosphate dehydrogenase in hepatic tissues and liver and muscle glycogen level were increased. The dosage of 400 mg/kg is more effective than that of 100, 200 mg/kg. These results suggest that the MVM possesses antidiabetic and hypolipidemic effects in streptozotocin -induced diabetic rats.

 

Key words:  Ventilago maderaspatana ,antihyperlipidemic ,antihyperglycemic and streptozotocin