DOCKING STUDIES ON ANTIMICROBIAL PEPTIDES RELATED TO APIDAECIN- IA AND HUMAN HISTATIN AGAINST GLUTAMINE SYNTHETASE AND RNA POLYMERASE IN MYCOBACTERIUM TUBERCULOSIS
Abstract
Currently need of novel molecules can be used to treat the tuberculosis including resistance multiple drug regimen (MDR) tuberculosis. Glutamine synthetase is an essential enzyme that produced the condensation reaction along with glutamate. It catalyses the glutamate react with ammonia, leads to the formation of glutamine and hydrolysis of ATP. In the brain it interact with glutamate regulation leads to detoxification of ammonia in the brain leads to termination of neurotransmitter signals. RNA polymerase catalyses the synthesis from a DNA template. It is a crucial enzyme for growth and survival of the mycobacteria. The compounds AIA-II, AIA-I were showed more potent against the Glutamine synthetase with glide score -8.79 and -7.97 as compared with standard Amikacin and Ciprofloxacin with glide score -7.71 and -3.45. The compounds AIA-I, AIA-II and HH-I were showed more potent against the RNA polymerase with glide score -10.12, -9.47 and -8.74 as compared with standard rifampicin and isoniazid with glide score -6.57 and -3.34.   Â
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