HETEROMORPHA ARBORESCENS: A REVIEW OF ITS BOTANY, MEDICINAL USES, AND PHARMACOLOGICAL PROPERTIES

Authors

  • Alfred Maroyi Department of Botany, Medicinal Plants and Economic Development Research Centre, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i11.29108

Keywords:

Apiaceae, Heteromorpha arborescens, Traditional medicine, Tropical Africa

Abstract

Heteromorpha arborescens is an important medicinal plant species throughout its distributional range in tropical Africa. This study evaluated the botany, medicinal uses, and pharmacological activities of H. arborescens. Literature focusing on the botany, phytochemical, pharmacological, and toxicological properties of H. arborescens were obtained from scientific databases such as SCOPUS, Science Direct, PubMed, SciFinder, Medline, and Google Scholar. Pre-electronic literature sources such as book chapters, books, journal articles, conference papers, and other scientific documents were obtained from the University library. Literature search revealed that H. arborescens is used as an aphrodisiac, as herbal medicine for shortness of breath, intestinal worms, inflammation, pain, respiratory problems, skin infections, headache, fever, and malaria. Pharmacological studies of compounds and H. arborescens extracts revealed anthelmintic, antiarthritic, antibacterial, antifungal, anti-inflammatory, antimycobacterial, antinociceptive, antioxidant, antipeptic ulcer, anti-scabies, antispasmodic, antiviral, cytotoxicity, genotoxicity, and uterotonic activities. More detailed research is needed aimed at assessing phytochemical, pharmacological, and toxicological properties of different plant parts and phytochemical compounds isolated from the species.

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Author Biography

Alfred Maroyi, Department of Botany, Medicinal Plants and Economic Development Research Centre, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.

Department of Botany, Professor

References

Van Wyk BE. A review of African medicinal and aromatic plants. In: Neffati M, Najjaa H, Máthé Ã, editors. Medicinal and Aromatic Plants of the World: Africa. Dordrecht: Springer; 2017. p. 19-60.

Van Wyk BE. The potential of South African plants in the development of new medicinal products. S Afr J Bot 2011;77:812-29.

Watt JM, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. Edinburgh: E and S Livingstone Ltd.; 1962.

Gelfand M, Mavi S, Drummond RB, Ndemera B. The Traditional Medical Practitioner in Zimbabwe: His Principles of Practice and Pharmacopoeia. Gweru: Mambo Press; 1985.

Hutchings A, Scott AH, Lewis G, Cunningham AB. Zulu Medicinal Plants: An Inventory. Pietermaritzburg: University of Natal Press; 1996.

Van Wyk BE, Van Oudtshoorn B, Gericke N. Medicinal Plants of South Africa. Pretoria: Briza Publications; 2013.

Setshogo MP, Mbereki CM. Floristic diversity and uses of medicinal plants sold by street vendor in Gaborone, Botswana. Afr J Pl Sci Biotechnol 2011;5:69-74.

Meke GS, Mumba RF, Bwanali RJ, Williams VL. The trade and marketing of traditional medicines in Southern and Central Malawi. Int J Sustain Dev World Ecol 2017;24:73-87.

Botha J, Weiersbye IM. Ethnobotanic and forage uses of plants on mine properties in the Witwatersrand basin gold fields, South Africa. In: Fourie A, Tibbett M, Wiertz J, editors. Mine Closure. Perth: Australian Centre for Geomechanics; 2010. p. 325-42.

Bussmann RW. Ethnobotany of the samburu of Mt. Nyiru, South Turkana, Kenya. J Ethnobiol Ethnomed 2006;2:35.

Long C. Swaziland’s Flora: SiSwati Names and uses. Swaziland National Trust Commission; 2005. Available from: http://www.sntc. Org.sz/index.asp. [Last accessed on 2018 May 21].

Winter PJ, Van Wyk BE. A revision of the genus Heteromorpha. Kew Bull 1996;51:225-65.

Calviño CI, Tilney PM, Wyk BE, Downie SR. A molecular phylogenetic study of Southern African Apiaceae. Am J Bot 2006;93:1828-47.

Van Wyk AE, Van Wyk P. Field Guide to Trees of Southern Africa. Cape Town: Struik Publishers (Pty) Ltd.; 1997.

Palgrave MC. Keith Coates Palgrave Trees of Southern Africa. 3rd ed. Cape Town: Struik Publishers (Pty) Ltd.; 2002.

Schmidt E, Lotter M, McCleland W. Trees and Shrubs of Mpumalanga and Kruger National Park. Johannesburg: Jacana; 2002.

Cannon JF. Umbelliferae. Conspectus Fl Angol 1970;4:340-3.

Cannon JF. Umbelliferae. In: LaunertE, editor. Flora Zambesiaca 4. London: Flora Zambesiaca Managing Committee; 1978. p. 578-81.

Townsend CC. Some notes on species of Heteromorpha (Umbelliferae). Kew Bull 1985;40:843-50.

Townsend CC. Umbelliferae. In: Polhill RM, editor. Flora of Tropical East Africa. Rotterdam: A.A. Balkema; 1989. p. 37-41.

Winter PJ, Van Wyk BE, Tilney PM. The morphology and development of the fruit of Heteromorpha (Apiaceae). S Afr J Bot 1993;59:336-41.

Winter PJ, Van Wyk BE. The taxonomic value of epidermal characters in the leaf of Heteromorpha and some related genera (Apiaceae). Bothalia 1994;24:187-94.

Setshogo MP, Venter F. Trees of Botswana: Names and Distribution. Pretoria: Southern African Botanical Diversity Network Report No. 18; 2003.

Da Silva MC, Izidine S, Amude AB. A Preliminary Checklist of the Vascular Plants of Mozambique. Pretoria: Southern African Botanical Diversity Network Report No. 30; 2004.

Burrows JE, Willis CK. Plants of the Nyika Plateau. Pretoria: Southern African Botanical Diversity Network Report No. 31; 2005.

Phiri PSM. A Checklist of Zambian Vascular Plants. Pretoria: Southern African Botanical Diversity Network Report No. 32; 2005.

Setshogo MP. Preliminary Checklist of the Plants of Botswana. Pretoria: Southern African Botanical Diversity Network Report No. 33, SABONET; 2005.

Hyde MA, Wursten BT, Ballings P, Palgrave CM. Heteromorpha arborescens (Spreng.) Cham. Schltdl. Var. Abyssinica (A. Rich.) H. Wolff. Flora of Zimbabwe: Species Information: Heteromorpha arborescens var. Abyssinica; 2018. Available from: https://www. zimbabweflora.co.zw/speciesdata/species.php?species_id=143100. [Last retrieved on 2018 Apr 21].

Arnold HJ, Gulumian M. Pharmacopoeia of traditional medicine in Venda. J Ethnopharmacol 1984;12:35-74.

Bryant AT. Zulu Medicine and Medicine-Men. Cape Town: C. Struik; 1966.

McGaw LJ, JägerAK, Van Staden J. Prostaglandin synthesis inhibitory activity in zulu, xhosa and sotho medicinal plants. Phytother Res 1997;11:113-7.

Lundgaard NH, Prior RM, Light ME, Stafford GI, Van Staden J, Jäger AK. COX-1 inhibition of Heteromorpha arborescens. Safr J Bot 2008;74:335-7.

Palmer E, Pitman P. Trees for Southern Africa Covering all Known Indigenous Species in Republic of South Africa, South West Africa, Botswana, Lesotho and Swaziland. Cape Town: A.A. Balkema; 1972.

Spencer P. Samburu Notions of Health and Disease, and their Relationship to Inner Cleanliness. SOAS Research Online, No 8764; 1959. Available from: https://www.eprints.soas.ac.uk. [Last retrieved on 2018 Apr 07].

Jacot-Guillarmod A. Flora of Lesotho. Lehre: J Cramer; 1971.

Van Wyk BE, Gericke N. People’s Plants: A Guide to Useful Plants of Southern Africa. Pretoria: Briza Publications; 2007.

Madikizela B, Kambizi L, McGaw LJ. An ethnobotanical survey of plants used traditionally to treat tuberculosis in the eastern region of O.R. Tambo district, South Africa. S Afr J Bot 2017;109:231-6.

Heyndrickx G, BrioenP, Van Puyvelde L. Study of Rwandese medicinal plants used in the treatment of scabies. J Ethnopharm 1992;35:259-62.

Ngari EW, Chiuri LW, Kariuki ST, Huckett S. Ethnomedicine of Ogiek of river Njorowatershed, Nakuru, Kenya. Ethnobot Res Appl 2010;8:135-52.

Maregesi SM, Mwakalukwa R. Ethnopharmacological study on medicinal plants used to treat infectious diseases in the Rungwe district, Tanzania. Int J Med Pl Nat Prod 2015;1:15-23.

Sewani-Rusike CR. Plants of Zimbabwe used as anti-fertility agents. Afr J Tradit Complement Altern Med 2010;7:253-7.

Moshi MJ, Mbwambo ZH. Experience of Tanzanian traditional healers in the management of non-insulin dependent diabetes mellitus. Pharm Biol 2002;40:552-60.

Erasto P, Adebola PO, Grierson DS Afolayan AJ. An ethnobotanical study of plants used for the treatment of diabetes in the Eastern Cape Province, South Africa. Afr J Biotechnol 2005;4:1458-60.

Hedberg I, Staugård F. Traditional Medicine in Botswana: Traditional Medicinal Plants. Gaborone: Ipelegeng Publishers; 1989.

Yemane B, Medhanie G, Reddy KS. Survey of some common medicinal plants used in Eritrean folk medicine. Am J Ethnomed 2017;4:14.

Mabogo DE. The Ethnobotany of the Vhavenda. MSc Dissertation, Pretoria: University of Pretoria; 1990.

Nkomo M, Kambizi L. Antimicrobial activity of Gunnera perpensa and Heteromorpha arborescens var. Abyssinica. J Med Pl Res 2009;3:1051-5.

Msonthi JD, Hostettmann K, Maillard MR. Phytochemical Studies of Medicinal Plants from Malawi. In: Hostettmann K, Chinyanganya F, Maillard MR, Wolfender JK, editors. Chemistry, Biological and Pharmacological Properties of African Medicinal Plants. Harare: University of Zimbabwe Publications; 1996. p. 171-86.

Fowler DG. Traditional Fever Remedies: Alist of Zambian Plants; 2006. Available from: http://www.giftsofhealth.org/ritam/news/Traditional_ Fever_remedie1.pdf. [Last accessed on 2018 Mar 11].

Stangeland T, Alele PE, Katuura E, Lye KA. Plants used to treat malaria in Nyakayojo sub-county, Western Uganda. J Ethnopharm 2011;137:154-66.

Desta B. Ethiopian traditional herbal drugs. Part II: Antimicrobial activity of 63 medicinal plants. J Ethnopharmacol 1993;39:129-39.

Hutchings A, van Staden J. Plants used for stress-related ailments in traditional zulu, xhosa and sotho medicine. Part 1: Plants used for headaches. J Ethnopharmacol 1994;43:89-124.

Moteetee A, Van Wyk BE. The medical ethnobotany of Lesotho: A review. Bothalia 2011;41:209-28.

Pujol J. Naturafrica: The Herbalist Handbook. Durban: Jean Pujol Natural Healers Foundation, Durban; 1990.

Abebe D, Hagos E. Plants as a primary source of drugs in the traditional health practices of Ethiopia. In: Engles JMM, Hawkes JG, Worede M, editors. Plant Genetic Resources of Ethiopia. Cambridge: Cambridge University Press; 1991. p. 101-13.

Parry O, Duri ZJ, Zinyama E. The effects of Heteromorpha trifoliata on gastrointestinal smooth muscle of the guinea pig. J Ethnopharm 1996;54:13-7.

Okello SV, Nyunja RO, Netondo GW, Onyango JC. Ethnobotanical study of medicinal plants used by sabaots of Mt. Elgon Kenya. Afr J Tradit Complement Altern Med 2009;7:1-0.

Chekole G, Asfaw Z, Kelbessa E. Ethnobotanical study of medicinal plants in the environs of Tara-gedam and Amba remnant forests of Libo Kemkem district, Northwest Ethiopia. J Ethnobiol Ethnomed 2015;11:4.

Gerstner J. A preliminary checklist of Zulu names of plants with short notes. Bantu Stud 1938;12:215-36, 321-42.

Masika PJ, Van Averbeeke W, Sonandi A. Use of herbal remedies by small scale farmers to treat livestock diseases in central Eastern Cape Province, South Africa. J Safr Vet Assoc 2000;71:87-91.

Villegas M, Vargas D, Msonthi JD, Marston A, Hostetmann K. Isolation of antifungal compounds falcarindiol and sarisan from Heteromorph atrifoliata. Planta Med 1988;54:36-7.

Recio MD, Just MJ, Giner RM, Manez S, Rios JL, Horstettmann K. Anti-inflammatory activity of saikosaponins from Heteromorph atrifoliata. J Nat Prod 1995;58:1404.

Makungo T, Van Ree T. Die aktiewe bestanddeel van wildepietersielie (Heteromorpha arborescens): 6,7-dimetoksikumarien. Suid Afr Tydskrif Nat Tegnol 2014;33:762.

Mwangi JW, Achola KJ, Lwande W, HassanaliA, Laurent R. Volatile components of Heteromorpha trifoliate (Wendl) Eckl. Zey. Flav Fragr J 1994;9:241-3.

Chagonda LS, Makanda CD, Chalchat JC. Essential oils of cultivated Heteropyxis natalensis (Harv.) and Cultivated Heteromorpha trifoliata (Wendl.) Eckl. Zey. From Zimbabwe. J Essential Oil Res 2000;12:317-21.

Deans SG, Kennedy AI, Gundidza MG, Mavi S, Waterman PG, Gray AI. Antimicrobial activities of the volatile oil of Heteromorpha trifoliata (Wendl.) Eckl. And zeyh (Apiaceae). Flav Fragr J 1994;9:245-8.

Elisha IL, Dzoyem JP, McGaw LJ, Botha FS, Eloff JN. The anti-arthritic, anti-inflammatory, antioxidant activity and relationships with total phenolics and total flavonoids of nine South African plants used traditionally to treat arthritis. BMC Complement Altern Med 2016;16:307.

McGaw LJ, Jäger AK, Van Staden J. Antibacterial, anthelmintic and anti-amoebic activity in South African medicinal plants. J Ethnopharm 2000;72:247-63.

Adamu M, Naidoo V, Eloff JN. Efficacy and toxicity of thirteen plant leaf acetone extracts used in ethnoveterinary medicine in South Africa on egg hatching and larval development of Haemonchus contortus. BMC Vet Res 2013;9:38.

Adamu M, Bagla VP, Eloff JN. Fractionation of Heteromorpha arborescens Var abyssinica (Apiaceae) leaf extracts based on polarity leads to a marked change in cytotoxicity that may yield a commercially useful product. S Afr J Bot 2016;103:36-40.

Adamu M, Naidoo V, Eloff JN. The antibacterial activity, antioxidant activity and selectivity index of leaf extracts of thirteen South African tree species used in ethnoveterinary medicine to treat helminth infections. BMC Vet Res 2014;10:52.

Elisha IL, Dzoyem JP, Botha FS, Eloff JN. The efficacy and safety of nine South African medicinal plants in controlling Bacillus anthracis sterne vaccine strain. BMC Complement Altern Med 2016;16:5.

Elisha IL, Botha FS, McGaw LJ, Eloff JN. The antibacterial activity of extracts of nine plant species with good activity against Escherichia coli against five other bacteria and cytotoxicity of extracts. BMC Complement Altern Med 2017;17:133.

Elisha IL, Jambalang AR, Botha FS, Buys EM, McGaw LJ, Eloff JN, et al. Potency and selectivity indices of acetone leaf extracts of nine selected South African trees against six opportunistic Enterobacteriaceae isolates from commercial chicken eggs. BMC Complement Altern Med 2017;17:90.

Madikizela B, McGaw LJ. Scientific rationale for traditional use of plants to treat tuberculosis in the Eastern region of the OR Tambo district, South Africa. J Ethnopharmacol 2018;224:250-60.

Adamu M, Naidoo V, Eloff JN. Some Southern African plant species used to treat helminth infections in ethnoveterinary medicine have excellent antifungal activities. BMC Complement Altern Med 2012;12:213.

Beuscher N, Bodinet C, Neumann-Haefelin D, Marston A, Hostettmann K. Antiviral activity of African medicinal plants. J Ethnopharm 1994;42:101-9.

Recio MD, Giner RM, Manez S, Rios JL, Horstettmann K. Screening of tropical plants for anti-inflammatory activity. Phytother Res 1995;9:571-4.

Nkomo M, Nkeh-Chungag BN, Kambizi L, Ndebia EJ, Sewani- Rusike C, Iputo JE, et al. Investigation of the antinociceptive and anti-inflammatory properties of Heteromorpha arborescens (Apiaceae). Afr J Tradit Complement Altern Med 2011;8:412-9.

Osim EE, Maredza T, Rao PV, Nhandara B, Adeyanju B, et al. Heteromorpha trifoliata (Dombwe) accelerates acetic acid induced peptic ulcers: A preliminary study in the rats. Cent Afr J Med 1999;45:35-40.

Katerere D, Parry O. Pharmacological actions of Heteromorpha trifoliata (dombweâ€) on rat isolated muscle preparations. Cent Afr J Med 2000;46:9-13.

Maroyi A. Dicoma anomala sond: A review of its botany, ethnomedicine, phytochemistry and pharmacology. Asian J Pharm Clin Res 2018;11:70-7.

Zaidi FB, Ahmed S, Makkad M. Role of effective project management in reducing drug development cost. Asian J Pharm Clin Res 2017;10:53-6.

Published

07-11-2018

How to Cite

Maroyi, A. “HETEROMORPHA ARBORESCENS: A REVIEW OF ITS BOTANY, MEDICINAL USES, AND PHARMACOLOGICAL PROPERTIES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 11, Nov. 2018, pp. 75-82, doi:10.22159/ajpcr.2018.v11i11.29108.

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