EVALUATION OF ACID HYDROLYSED STARCH DERIVED FROM DIGITARIA IBURUA AS BINDER

Authors

  • GIDEON O OKPANACHI
  • Hassan Musa
  • Adamu B Isah

Abstract

 

 Objective: This research work was aimed at investigating the binding properties of Digitaria iburua starch (DS) and acid hydrolyzed starch or microcrystalline starch (MCS) in the formulation of metronidazole (MET) tablet comparing it with gelatin (GLT) as a standard binder.

Methods: DS was obtained from steeping the D. iburua grains in water. MCS was produced using 6 N HCl at 50°C for 24 hrs. The dilution potential test was conducted. MET granules of binder concentrations (2.5, 5.0, 7.5, 10.0 and 12.5% w/v) of DS and MCS was prepared by wet granulation method and compared with GLT. The granules flow properties were evaluated. The particle size distribution of the granules was determined. The quality of tablets was assessed by standard methods.

Results: A yield of 62.88% w/w DS was obtained whereas MCS was found to be 85.14% w/w. The MCS was unable to bind MET at all ratios. The granules had good flow and compressible properties and are uniformly distributed. The crushing strength (CS) of the binder types is ranked: GLT>MCS>DS. The friability (FR) values decreased with increase in binder concentration for all binder types. Only FR at 12.5% w/v of MCS and GLT was <1%. The disintegration time (DT) increased with increase in binder concentration. The (CS/FR)/DT values of DS and MCS obtained >2.

Conclusion: The Carr's index, Hausner's ratio and (CS/FR)/DT values suggests that DS and MCS are poor binders.

Keywords: Acid hydrolyzed starch, Excipients, Digitaria iburua, Metronidazole.

 

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References

Itiola OA, Odeku OA. Packing and cohesive properties of some locally extracted starches. Trop J Pharm Res 2005;4(1):363-8.

Rowe SK, Sheskey PJ. Excpients. In: Weller PJ, editor. Handbook of Pharmaceutical Excipients. 4th ed. London: Pharmaceutical Press; 2003. p. 603-4.

Ashford M. Bioavailability. In: Aulton ME, editor. Pharmaceutics - The Science of Dosage Form Design. 2nd ed. London: Churchill Livingstone Elsevier; 2002. p. 234-52.

Musa H, Gambo A, Bhatia PG. Studies on some physicochemical properties of native and modified starches from Digitaria iburua and Zea mays. Int J Pharm Pharm Sci 2011;3(1):28-31.

Mohammed BB, Isah AB, Ibrahim MA. Influence of compaction pressure on modified cassava starch as a binder in paracetamol tablet formulation. Niger J Pharm Sci 2009;8(1):80-8.

Olorunsola EO, Isah AB, Zaman YE. Physicochemical properties of Borassus aethiopum starch. Asian J Pharm Clin Res 2012;5(3):132-4.

British Pharmacopoeia. Her Majesty’s Stationery Office. Vol. 1 and II. Cambridge: University Press; 2002.

Staniforth JN. Powder flow. In: Aulton ME, editor. The Design and Manufacture of Medicine. 3rd ed. Edinburgh, NY, USA: Churchill Livingstone Elsevier; 2007. p. 168-179.

Hausner NH. Flow properties of some pharmaceutical powders. Int J Powder Metallurgy 1967;3:7-11.

Schwartz JB, Martin ET, Dehner EJ. Intragranular starch: Comparison of starch USP and modified cornstarch. J Pharm Sci 1975;64(2):328-32.

Rawlins EA. Tablets and capsules. In: Bently’s Textbook of Pharmaceutics. 8th ed. New Delhi: AITBS Publishers India; 2004. p. 269-318.

Alebiowu G, Adeagbo AA. Disintegrant properties of a paracetamol tablet formulation lubricated with co-processed lubricants. Farmacia 2009;57(4):500-10.

Ogaji I, Okafor IS. Binding effects of two brands of pregelatinised starch on acetaminophen tablets in a wet granulation process. Niger J Pharm Sci 2009;8(1):54-65.

Published

01-11-2014

How to Cite

OKPANACHI, G. O., H. Musa, and A. B. Isah. “EVALUATION OF ACID HYDROLYSED STARCH DERIVED FROM DIGITARIA IBURUA AS BINDER”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 5, Nov. 2014, pp. 160-3, https://mail.innovareacademics.in/journals/index.php/ajpcr/article/view/3043.

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