EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS

RAMACHANDRAN S; SRI RAMYA M; LIZA U; LAKSHMI PRASANNA PS; SARISHMA K

doi:10.22159/ajpcr.2019.v12i3.30720

Authors

RAMACHANDRAN S Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
SRI RAMYA M Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
LIZA U Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
LAKSHMI PRASANNA PS Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.
SARISHMA K Department of Pharmacology, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i3.30720

Keywords:

Nil

Abstract

Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats.

Methods: The male Wistar rats were selected and divided into six groups. Group I received distilled water, Group II received AlCl3 ( 100 mg/kg, p.o.), Group III received rivastigmine (1 mg/kg, p.o.), Group IV received AlCl3 + shrimp powder (200 mg/kg, p.o), and Group V received AlCl3 + shrimp powder (400 mg/kg, p.o) for 60 days. At the end of the study, various parameters such as behavioral and biochemical investigations were assessed.

Results: The result of the study shows that the shrimp (400 mg/kg) has better effect on the treatment of aluminum chloride-induced AD in rats. It showed a remarkable improvement in the behavioral and biochemical parameters, and the result of histopathology study shows that the hippocampus region of brain tissue recovered as compared with control.

Conclusion: From this study, it is evident that dietary intake of shrimp can help to inhibit oxidative stress produced due to the accumulation of AlCl3 in the brain and used as a prophylactic for AD.

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