DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF TOPICAL GEL CONTAINING ITRACONAZOLE - ANTIFUNGAL AGENT

Pavithra K

doi:10.22159/ajpcr.2018.v11s4.31725

Authors

Pavithra K Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s4.31725

Keywords:

Itraconazole, Carbopol 940, Zeta potential, Stability study

Abstract

Objective: The main purpose of this study was to develop a topical delivery of itraconazole to reduce the dose of the drug, to improve patient compliance, and to avoid the side effects. Itraconazole is a triazole derivative to treat antifungal and antiprotozoal infections.

Methods: Topical gel formulations of itraconazole were prepared using Carbopol 940 as a gelling agent with different concentrations. Four different formulations were prepared and evaluated with respect to color, spreadability, viscosity measurement, determination of pH, drug content, in vitro drug release studies, zeta potential studies, and stability studies. Compatibility study was carried out by Fourier-transform infrared (FT-IR) spectral analysis.

Results: FT-IR study revealed that there were no significant interaction between the drug and polymers. All the prepared formulations show acceptable physical properties. The drug content and percentage yield were higher for F1 formulation among all formulation F1 shows better drug release. Stability study of best formulation shows that there was no difference in drug content and in vitro drug release studies.

Conclusion: From the above observation results that this formulation may be more encouraging topical substitute for the healing of fungal infections in the skin.

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References

Rathod HJ, Mehta DP. A review on pharmaceutical gel. Acta Sci Int J Pharm Sci 2015;l:33-47.

Verma A, Singh S, Kaur R, Jain UK. Topical gels as drug delivery systems: A review. Int J Pharm Sci Rev Res 2013;23:374-82.

Smart JD, Mortazavi SA. Drug delivery research group. J Pharm Pharmacol 1994;46:86-90.

Bhalaria M, Naik S, Misra A. A novel delivery system for antifungal drugs in the treatment of topical fungal disease. Indian J Exp Biol 2009;47:368-75.

Gupta GD, Gound RS. Release rate of nimesulide from different gallants. Indian J Pharm Sci 1999;61:229-34.

Sera UV, Ramana MV. In vitro skin absorption and drug release-a comparison of four commercial hydrophilic gel preparations for topical use. Indian Pharm 2003;73:356-60.

Sahoo SK, Samal AR. Estimation and evaluation of secnidazole. Indian Pharm 2006;5:73.

Basha BN, Prakasam K, Goli D. Formulation and evaluation of gel containing fluconazole-antifungal agent. Int J Drug Dev Res 2011;3:109-28.

Deveda P, Jain A, Vyas N, Khambete H, Jain S. Jellified emulsion for sustain delivery of itraconazole for topical fungal diseases. Int J Pharm Pharma Sci 2010;2:104-12.

Shah M, Modi D, Shah D. Formulation, design and evaluation of microemulsion and micro emulgel of itraconazole for topical application. Int J Pharm Pharm Res 2017;9:125-46.

Nirosha M, Varsh KH, Prema AR, Samdani K, Amrutha V, Reddy LD. Formulation and evaluation of itraconazole ophthalmic in situ gels. J Power Source 2017;4:1101-8.

Baudonnet L, Pere D, Michaud P, Grossiord JL, Rodriguez F. Effect of dispersion stirring speed on the particle size distribution and rheological properties of carbomer dispersions and gels. J Dispers Sci Tech 2002;23:499-510.

Gupta A, Mishra AK, Singh AK, Gupta V, Bansal P. Formulation and evaluation of topical gel of diclofenac sodium using different polymers. Drug Invent Today 2010;5:250-3.

Skiba M, Skiba-Lahiani M, Marchais H, Duclos R, Arnaud P. Stability assessment of ketoconazole in aqueous formulations. Int J Pharm 2000;198:1-6.

Shivhare UD, Jain KB, Mathur VB, Bhusari KP, Roy AA. Formulation development and evaluation of diclofenac sodium gel using water-soluble polyacrylamide polymer. Dig J Nanomater Biostruct 2009;2:285-90.

Marjukka Suhonen T, Bouwstra JA, Urtti A. Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. J Control Release 1999;59:149-61.

Chudasama A, Patel V, Nivsarkar M, Vasu K, Shishoo C. Investigation of microemulsion system for transdermal delivery of

traconazole. J Adv Pharm Technol Res 2011;2:30-8.