BLOOD PRESSURE LOWERING EFFECT OF POLYHERBAL PREPARATION CONTAINING ALLIUM SATIVUM, BELERICAE FRUCTUS, CURCUMA AERUGINOSA, AND AMOMI FRUCTUS ON RAT MODEL OF HYPERTENSION
DOI:
https://doi.org/10.22159/ajpcr.2019.v12i4.31750Keywords:
polyherbal preparation, Alium sativum, Belericae fructus, Curcuma aeruginosae, Amomi fructus, blood pressureAbstract
Objective: The study aimed to investigate the blood pressure lowering effect of the polyherbal preparation contains Allium sativum, Belericae fructus, Curcuma aeruginosa, and Amomi fructus in the animal model of hypertension.
Methods: Deoxycorticosterone acetate uninephrectomy salt rat model was used to develop hypertension model. Hypertensive rats were divided into five groups that were no treatment (negative control group [NEG]), hydrochlorothiazide treatment, polyherbal preparation 63 mg/kg treatment (DOSE 1), polyherbal preparation 126 mg/kg treatment (DOSE 2), and polyherbal preparation 252 mg/kg treatment (DOSE 3). The treatment was started after hypertension developed and given for 3 weeks.
Results: The result showed that the mean of systolic blood pressure in DOSE 2 group was significantly lower compared with those on NEG group (145.86 mmHg vs. 174.71 mmHg, p<0.05).
Conclusion: Our study provides evidence to support the use of the polyherbal preparation containing A. sativum, B. fructus, C. aeruginosa, and A. fructus for lowering blood pressure.
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References
Reinhart KM, Coleman CI, Teevan C, Vachhani P, White CM. Effects of garlic on blood pressure in patients with and without systolic hypertension: A meta-analysis. Ann Pharmacother 2008;42:1766-71.
Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord 2008;8:13.
Saraswathi NM, Karthikeyan M, Kannan M, Rajasekar S. Terminalia bellerica roxb. A phytopharmacological review. Int J Res Pharm Biomed Sci 2012;3:96-9.
Khan AU, Gilani AH. Pharmacodynamic evaluation of Terminalia belerica for its antihypertensive effect. J Food Drug Anal 2008;16:6-14.
Choudhury D, Ghosal M, Das AP, Mandal P. Development of single node cutting propagation techniques and evaluation of antioxidant activity of C. aeruginosa, Roxburg hrizhome. Int J Pharm Pharm Sci 2013;5:227-34.
Nurcholis W, Priosoeryanto BP, Purwakusumah ED, Katayama T, Suzuki T. Antioxidant, cytotoxic activities and total phenolic content of four Indonesian medicinal plants. Valensia 2012;2:501-10.
Suo S, Lai Y, Li M, Song Q, Cai J, Zhao J, et al. Phytochemicals, pharmacology, clinical application, patents, and products of Amomi fructus. Food Chem Toxicol 2018;119:31-6.
Pinto YM, Paul M, Ganten D. Lessons from rat models of hypertension: From goldblatt to genetic engineering. Cardiovasc Res 1998;39:77-88.
James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA 2014;311:507-20.
Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther 2010;8:793-802.
Dhawan V, Jain S. Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem 2004;266:109-15.
Pramod SN, Vellingiri V, Venkatesh YP. Immunomodulatory effects of hemagglutinating lectins from potato (Solanum tuberosum) and garlic (Allium sativum) on human and murine lymphocytes. Int J Pharm Pharm Sci 2015;7 Supp 1:147-53.
Divya BJ, Suman B, Venkataswamy M, Thyagaraju K. A study on phytochemical, functional groups and mineral composition of Allium sativum (garlic) cloves. Int J Curr Pharm Res 2016;9:42-5.
Al-Qattan KK, Thomson M, Al-Mutawa’a S, Al-Hajeri D, Drobiova H, Ali M. Nitric oxide mediates the blood-pressure lowering effect of garlic in the rat two-kidney, one-clip model of hypertension. J Nutr 2006;136:774S-6S.
Sinha N, Dabla PK. Oxidative stress and antioxidants in hypertension-a current review. Curr Hypertens Rev 2015;11:132-42.
Kizhakekuttu TJ, Widlansky ME. Natural antioxidants and hypertension: Promise and challenges. Cardiovasc Ther 2010;28:e20-32.
Safaeian L, Ghannadi A, Javanmard SH, Vahidian MH. The effect of hydroalcoholic extract of Ferula foetida stems on blood pressure and oxidative stress in dexamethasone-induced hypertensive rats. Res Pharm Sci 2015;10:326-34.
Kardum N, Milovanović B, Šavikin K, Zdunić G, Mutavdžin S, Gligorijević T, et al. Beneficial effects of polyphenol-rich chokeberry juice consumption on blood pressure level and lipid status in hypertensive subjects. J Med Food 2015;18:1231-8.
Tamuli S, Kakati S, Das S, Singh KD, Ghosh SK. Comparative studies of efficacy and effect of oxidative stress of amlodipine and ramipril in the hypertensive patients of North East India. Int J Pharm Pharm Sci 2015;7:118-21.
Bouayed J, Bohn T. Exogenous antioxidants – double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev 2010;3:228-37.
Weinberg RB, VanderWerken BS, Anderson RA, Stegner JE, Thomas MJ. Pro-oxidant effect of Vitamin E in cigarette smokers consuming a high polyunsaturated fat diet. Arterioscler Thromb Vasc Biol 2001;21:1029-33.
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