FORMULATION AND EVALUATION OF CLOBETASOL PROPIONATE GEL
Abstract
Objective: The aim of the study was to formulate Clobetasol propionate into a gel formulation using carbopol-934, Hydroxypropyl methylcellulose K4M, sodium alginate, Carboxymethylcellulose Sodium as gelling agents.
Method: In all the gels formulated, the concentration of propylene glycol and ethanol was kept constant at 15% and 40 % respectively. Clobetasol propionate was used in the concentration of 0.05% in all the gel formulations. Propylene glycol served as a co-solvent for drug. Triethanolamine was used to neutralize carbopol gel systems. Methyl paraben and propyl paraben were used as preservatives. A total of twenty two formulations were prepared with 6 formulation containing combination of various gelling agents. The total concentration of gelling agent in these six formulations was kept constant at 2%. The remaining sixteen formulations were prepared with the use of four different gelling agents viz., Carbopol-934, Hydroxypropyl methylcellulose K4m, Carboxymethylcellulose Sodium and Sodium Alginate.Formulations were evaluated for pH, homogeneity, grittiness, viscosity, spreadability, drug content and In-Vitro drug release studies.
Results: Drug content was high (>98 %) in gels. Carbopol-934 and Hydroxypropyl methylcellulose K4M gels showed higher release of .the drug compared to Carboxymethylcellulose Sodium and Sodium Alginate The viscosity of carbopol-934 gels was very high as compared to Hydroxypropyl methylcellulose K4M gels but both gels showed decrease in drug release with increase in polymer concentration. Similarly, gels prepared with combination of carbopol-934 and Hydroxypropyl methylcellulose K4M showed better drug release than gels prepared with Carboxymethylcellulose sodium and sodium alginate.
Conclusion: The study indicated that the polymer concentration significantly affects the drug release and rheological properties of the gel formulation. The study holds promise for further investigation in the development stable topical gels of clobetasol propionate.
Downloads
References
Gordon LF General Introduction and Conceptual Differentiation of Topical and Transdermal Drug Delivery Systems. In: Shah VP, Maibach HI, editors. Topical Drug Bioavailability, Bioequivalence and Penetration. 1st ed. Springer US; 1993. p. 369-391.
Gisby J, Bryant J. Efficacy of a new cream formulation of mupirocin: Comparison with oral and topical agents in Experimental skin infections. Antimicrobial agents and chemotherapy 2000; 44(2): 255-260.
Bhasha SA, Khalid SA, Duraivel S, Bhowmik D, Kumar KS. Recent Trends in Usage of Polymers in the Formulation of Dermatological Gels. Ind J Res Pharmacy Biotech 2013; 1(2): 161-168.
Yasir EN, Khashab AL, Yasir MK, Hamadi SA, Al-Waiz MM. Formulation and evaluation of ciprofloxacin as a topical gel. Asian J Pharm Sci 2010; 8(2): 80-95.
Uche DOV. Sol-gel technique: A veritable tool for crystal growth. Advances in applied Sci Res 2013; 4(1): 506-510.
Norris DA. Mechanisms of action of topical therapies and the rationale for combination Therapy. J Am Acad Derm 2005; 53(1): 17-25.
Olsen EA, Cornell RC. Topical clobetasol-17-propionate: review of its clinical efficacy and safety. J Am Acad Derm 1986; 15(2): 246-255.
Jarratt M, Breneman D, Gottlieb AB, Poulin Y, Liu Y, Foley V. Clobetasol propionate shampoo 0.05%: a new option to treat patients with moderate to severe scalp psoriasis. J Drugs in Derm 2003; 3(4): 367-373.
Jacobson C, Cornell RC, Savin RC. A comparison of clobetasol propionate 0.05 percent ointment and an optimized betamethasone dipropionate 0.05 percent ointment in the treatment of psoriasis. Cutis; Cutaneous Med Prac 1986; 37(3): 213.
Gupta V, Formulation and evaluation of naproxen gel containing tulsi oil as penetration enhancer. Int J Pharm Clin Res 2009; 1(3): 153-155.
Barhate SD. Development of Meloxicam sodium transdermal gel. Int J Pharm Res Dev 2000; 2(5): 1-4.
Dhawan S, Medhi B, Chopra S. Formulation and evaluation of diltiazem hydrochloride gels for the treatment of anal fissures. Scientia Pharmaceutica 2009; 77(2): 465-482.
Valenta C, Nowak M, Hadgraft J. Influence of phloretin and 6- ketocholestanol on the permeation of progesterone through porcine skin. Int J Pharm 2001; 217(1): 79-86.
Cordero JA, Alarcon L, Escribano E, Obach, Domenech J. A Comparative study of the transdermal penetration of a series of Nonsteroidal anti-inflammatory drugs. J Pharm Sci 1997; 86(4): 503-508.
Patel J, Patel B, Banwait H, Parmar K, Patel M. Formulation And Evaluation of Topical Aceclofenac Gel Using Different Gelling Agent. Int J Drug Dev Res 2011; 3(3): 9275-9344.
Gohel MC, Jani GK, Amin A, Bajaj S, Dave BS. Application of simplex lattice design for the development of transdermal gels of diclofenac Sodium. J Pharm Sci 2000; 62(2): 108-114.
Khar RK, Ali J, Ahuja A. Dosage form design: stabilization of pharmaceutical products and stability testing. 5th edn. Birla publications Pvt. Ltd 2010. p. 84-124.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.