BILAYER TABLET TENDERED IMMEDIATE RELEASE OF PARACETAMOL AND SUSTAINED RELEASE OF IBUPROFEN FOR QUICK ONSET OF ACTION AGAINST PAIN AND FEVER

DEVENDER CHAUHAN; DINESH KAUSHIK

doi:10.22159/ajpcr.2019.v12i11.35690

Authors

DEVENDER CHAUHAN Department of Hindu College of Pharmacy, Sonipat, Haryana, India.
DINESH KAUSHIK Department of Hindu College of Pharmacy, Sonipat, Haryana, India.

DOI:

https://doi.org/10.22159/ajpcr.2019.v12i11.35690

Keywords:

Paracetamol, Ibuprofen, Analgesic, Immediate release, Sustained release, High-performance liquid chromatography

Abstract

Objective: The objective of this research was to formulate bi-layer tablet which contains immediate-release layer of Paracetamol for quick onset of action and sustained release of Ibuprofen for prolonging long period.

Materials and Methods: The following chemicals were used: Paracetamol (Combiotic Global Pvt. Ltd., India), Ibuprofen (Combiotic Global Pvt. Ltd., India), microcrystalline cellulose (MCC) (Avicel), and Polyvinylpyrrolidone (PVP) K-30 (Loba Chem). Wet granulation method was adapted to formulate the bilayer tablets. The immediate-release layer of Paracetamol was prepared using sodium starch glycolate as superdisintegrants, MCC as diluent, starch as binder. The sustained release layer of Ibuprofen was prepared using high-performance liquid chromatography E50LV and ethyl cellulose as binder along with other excipients such as MCC, PVP, and magnesium stearate by wet granulation technique.

Result and Discussion: The release rate of Paracetamol from Formulations 1 was more than 80% at 40 min. In case of Ibuprofen, sustained-release polymers such as HPMC E50 LV were used to increase the release time.

Conclusion: The bilayer tablets were prepared and show good release rate.

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References

Khaleel S, Patil P, Bhagat M. Bilayer tablet an emerging trend. Eur J Pharm Med Res 2017;4:471-80.

Gopinath C, Hima V. An overview on bilayered tablet technology. J Glob Trends Pharm Sci 2013;4:1085-98.

Verma R, Kishor D. Bi-layer tablets for various drugs. Sch Acad J Pharm 2014;3:271-9.

Bhatia E, Vaishy P, Mishra A, Pathak A. Bilayered tablet technology. Int J Pharm Biol Arch 2014;5:9-18.

Devtalu S, Patil A, Bari M. A review on novel approach bilayer tablet technology. Int J Pharm Sci Rev Res 2013;21:46-52.

Reddy P, Rao D, Kumar R. Bi-layer technology an emerging trend: A review. Int J Res Dev Pharm Life Sci 2013;2:404-11.

Trpathi KD. Essentials of Medical Pharmacology. 6th ed. New Delhi: Jaypee Brothers; 2003. p. 193, 198-9.

Shirse P. Formulation and evaluation of bilayer tablets of diclofrenac sodium with ranitidine HCL for sustained and immediate release. J Appl Pharm Sci 2012;2:136-41.

Payghan S, Disuza J. Formulation, evaluation and development of bilayer tablet. Int J Pharm Res Dev 2011;3:80-7.

Darekar A, Jadhav S, Saudager R. Bilayer tablet technology: An overview. Int J ChemTech Res 2017;10:595-603.

Zhu C, Xu S, Han X, Wang W, He W, Yin L, et al. Sustained release bilayer tablet of ibuprofen and phenylephrine hydrochloride: Preparation and pharmacokinetics in beagle dogs. AAPS PharmSciTech 2019;20:86.

Sarangi MK, Chowdary K, Sundriyal A. Formulation development and evaluation of bilayer tablets containing paracetamol sr and tizanidine. J Appl Pharm 2014;6:347-59.

Sudhakar M, Rao V, Samalla N. Development and optimization of paracetamol immediate release and aceclofenac controlled release bilayer tablets. Am J Adv Drug Deliv 2013;1:93-101.

Yasmeen Z, Mamatha T, Farheen H. Dissolution method development and validation for combination of ibuprofen and paracetamol tablets. Asian J Pharm| Clin Res 2013;6:162-6.

Payghan S, Disuza J. Formulation, evaluation and development of bilayer tablet. Int J Pharm Res Dev 2011;3:80-7.

Islam SA, Banu H, Mostafa R. Bilayer tablets of paracetamol and aceclofenac: formulation and evaluation. Int J Pharm Technol 2011;17:811-22.

Hosna B, Sahariar M, Shahdaat M. Formulation development of bi-layer acetaminophen tablets for extended drug release. J Chem Pharm Res 2011;3:348-60.

Biljana G, Rade I. Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression. Afr J Pharm Pharmacol 2011;5:31-41.

Rahman M, Roy S. Evaluation of various grades of hydroxypropylmethylcellulose matrix systems as oral sustained release drug delivery systems. J Pharm Sci Res 2011;3:930-8.

Shiyani B, Gattani S, Surana S. Formulation and evaluation of bi-layer tablet of metoclopramide hydrochloride and ibuprofen. AAPS PharmSciTech 2008;9:818-27.

Indian Pharmacopoeia. Government of India, Ministry of health and family welfare. Ghaziabad: Published by The Indian Pharmacopoeia Commission; 2018. p. 1217-8, 1514-7.

Saiesh P, Shabaraya AR, Shripathy D. Kinetic modelling of drug release. Int J Univ Pharm Biosci 2014;3:92-104.