PREPARATION AND CHARACTERISATION OF BORA RICE ACECLOFENAC MICROSPHERES
Abstract
Â
Objective: The present research work is based on the applicability of bora rice as a natural polymer for preparing sustained aceclofenac bora rice
microspheres.
Methods: The microspheres were prepared by emulsion solvent diffusion technique.†The physicochemical characterizations of the prepared
microspheres (percentage drug entrapment efficiency, scanning electron microscopy, percentage drug loading) were carried out as well as the in vitro
drug release was carried out in phosphate buffer pH 6.8.
Result: The prepared microspheres were found to have a regular spherical shape, percentage drug entrapment efficiency of 52.6%. The in vitro
release study in phosphate buffer pH 6.8 showed a sustained release of the drug for 24 hrs.
Conclusion: The bora rice as a natural biodegradable polymer could efficiently sustained the release of aceclofenac for 24 hrs.
Keywords: Bora rice, Aceclofenac, Scanning electron microscope, Sustained release.
Downloads
References
Patel JK, Patel RP, Amin AF, Patel MM. Formulation and evaluation of mucoadhesive glipizide microspheres. AAPS Pharm Sci Tech 2005;6(1):49-55.
Vyas SP, Khar RK. Targeted and Controlled Drug Delivery. Novel Carrier Systems. Ch. 13. New Delhi: CBS Publishers and Distributers; 2002. p. 487-511.
Jayakrishnan A, Latha MS. Biodegradable polymeric microspheres as drug carriers. In: Jain NK, editors. Controlled and Novel Drug Delivery. New Delhi: CBS Publishers; 1997. p. 236-55.
Beckett AH. Alternative routes of drug administration and new drug delivery systems. In: Breimer DD, editors. Towards Better Safety of Drug and Pharmaceutical Products. North Hollan: Elsevier Biomedical Press; 1980. p. 247-63.
Sharma HK, Lahkar S, Kanta Nath L. Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources. Acta Pharm 2013;63(2):209-22.
Prasad BS, Setty CM, Gupta VR, Devanna D, Devi MR. Aceclofenac-loaded alginate microspheres prepared by ionotropic gelation method: Effect of formulation variables on encapsulation efficiency, morphology and release characteristics. Der Pharm Lett 2011;3(2):10-24. Available from: http://scholarsresearchlibrary.com/DPL-vol3-iss2/DPL-2011-3-2-10-24.pdf.
Shilpa A, Agrawal SS, Ray AR. Controlled delivery of drugs from alginate matrix. J Macromol Sci Part C Polym Rev 2003;43:187-221.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.