EVALUATION OF SERUM INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA LEVELS IN PATIENTS WITH DENGUE FEVER – A TERTIARY CARE HOSPITAL BASED STUDY

ROHIN DUBBAL; SRIRAM BS

doi:10.22159/ajpcr.2020.v13i4.36877

Authors

ROHIN DUBBAL Department of General Medicine, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.
SRIRAM BS Department of Pharmacology, K.S. Hegde Medical Academy, Mangalore, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i4.36877

Keywords:

Interleukin-6, Tumor necrosis factor-alpha, Dengue infection

Abstract

Objective: The objective of the study was to evaluate the levels of serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) during the course of 3rd and 5th days of dengue infection.

Methods: The prospective cohort study was taken up involving 50 adults diagnosed with dengue fever and admitted to Mysore Medical College and Research Institute from December 2015 to November 2016. Detailed history has been taken and clinical examination was carried out. Venous blood sample was collected and serum separated out for estimation of IL-6 and TNF-α levels using ELISA.

Results: It has been observed that the levels of IL-6 and TNF-α raised during 3rd day of infection and there is decrease in levels of IL-6 and no changes have been observed in TNF-α levels during 5th day.

Conclusion: The study concludes that the IL-6 and TNF-α plays a key role in understanding pathogenesis of severity of dengue infection, TNF-α being more sensitive in reaction to pathogen

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