THE CURIOUS CASE OF LOMITAPIDE
Abstract
Lomitapide is a new Microsomal transfer protein inhibitor. It has been approved as an orphan drug for treating homozygous familial hypercholetelemia. The drug went through various see-saw phases in its brief life. Understanding the life history of Lomitapide gives a unique opportunity to analyze diverse case scenarios during clinical trials and their rectification by using scientific methodology.Â
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Hussain MM, Shi J, Dreizen P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res. 2003 Jan;44(1):22-32.
FDA approves new orphan drug for rare cholesterol disorder. FDA NEWS RELEASE (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm333285.htm, assessed on 1st May 2014)
Paracelsus. Toxipedia (http://www.toxipedia.org/display/toxipedia/Paracelsus, Accessed on 1st September 2014)
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