A COMPARATIVE STUDY OF ANTI-NOCICEPTIVE ACTIVITY OF CURCUMA LONGA LINN. WITH THAT OF IBUPROFEN IN EXPERIMENTAL ANIMALS

SWOPNA PHUKAN; SAHELI DAS

doi:10.22159/ajpcr.2020.v13i6.37224

Authors

SWOPNA PHUKAN Department of Pharmacology, Gauhati Medical College, Guwahati, Assam.
SAHELI DAS Department of Pharmacology, Gauhati Medical College, Guwahati, Assam.

DOI:

https://doi.org/10.22159/ajpcr.2020.v13i6.37224

Keywords:

Curcuma longa, Ibuprofen, Anti-nociceptive activity

Abstract

Objective: The aim of the study is to evaluate and compare the analgesic activities of Curcuma longa Linn. in the experimental animals.

Methods: The present study was conducted in the Department of Pharmacology, Gauhati Medical College and Hospital, after getting approval from the Institutional Animal Ethics Committee (No MC/68F/2009/MAR-19/02). Healthy rodents weighing between 150 and 200 g were selected and randomly divided into five groups, each group consisting of six animals. Tail-flick analgesiometer was used to assess the analgesic activity of C. longa Linn. and ibuprofen in the experimental animals. Appropriate statistical analyses like Student’s t-test were used to analyze the data.

Results: The mean reaction time (s) was prolonged on gradually increasing the dose of C. longa Linn. from 200 to 400 mg/kg. At 400 mg/kg dose C. longa Linn. produced similar analgesic activity as compared to ibuprofen (30 mg/kg).

Conclusion: From the study, it can be concluded that curcumin has the capacity to attenuate pain, and when administered in high doses, may produce similar activity as other conventional NSAID’s.

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